Patents Examined by Lara Chapman Kelley
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Patent number: 5853696Abstract: Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease.Type: GrantFiled: February 20, 1996Date of Patent: December 29, 1998Assignees: Organix, Inc., The General Hospital Corporation, The President and Fellows of Harvard College, Northeastern UniversityInventors: David R. Elmaleh, Bertha K. Madras, Peter Meltzer, Robert N. Hanson
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Patent number: 5840273Abstract: The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to a radiopharmaceutical compositions comprising the complexes, to the use of the compositions for examining the renal function, and to a kit for preparing such compositions.Type: GrantFiled: May 26, 1995Date of Patent: November 24, 1998Inventor: Dennis L. Nosco
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Patent number: 5716596Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhemium-186 (.sup.186 Re ) and rhenium-188 (.sup.188 Re ), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: June 23, 1992Date of Patent: February 10, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5696239Abstract: A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.Type: GrantFiled: June 6, 1995Date of Patent: December 9, 1997Assignee: The Dow Chemical CompanyInventors: David A. Wilson, Joseph R. Garlich, R. Keith Frank, Kenneth McMillan
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Patent number: 5690903Abstract: Methods for the preparation and use of a biological delivery system are disclosed. The method of preparation includes the loading of a non-biological material into a biostructure having a load-bearing structure. The method also includes the removal of some of the biostructure's contents and the loading of a non-biological material into the biostructure. The biostructure is biologically compatible with the host, and preferably is derived from the host, the host's species or a related species. The loaded biostructure is used directly, or it can be targeted to specific cells, tissues and/or organs within a host. The targeted biostructure can be used to deliver the non-biological material to a specified tissue, organ or cell within a host for diagnostic, therapeutic or other purposes.Type: GrantFiled: May 30, 1995Date of Patent: November 25, 1997Inventor: James F. Hainfeld
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Patent number: 5688487Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprisinga metal, preferably radionuclide of rhenium or technetium;a hypoxia-localizing moiety; and,a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.Type: GrantFiled: June 6, 1995Date of Patent: November 18, 1997Assignee: Bracco International B.V.Inventors: Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
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Patent number: 5674985Abstract: Novel cerium (IV) oxidic compounds, well suited as catalysts, e.g., for the clean combustion of hydrocarbon fuels and for the "drying" of paint compositions, each Ce(IV) atom of which being coordinated with two anions of an organic oxyacid advantageously having a pKa greater than 1, preferably greater than 2, or a mixture of such oxyacids, and the oxidic oxygen atom or atoms of which being other than those comprising the organic oxyacids; representative such novel cerium (IV) oxidic compounds, whether yellow crystalline solids or yellow liquids, have the formula:(H.sub.2 O).sub.p ?Ceo(A).sub.2.(AH).sub.n.!.sub.min which the radicals A, which may be the same or different, are each the residue of an organic oxyacid of formula AH, p is an integer ranging from 0 to 5, n ranges from 0 to 2 and m is an integer ranging from 1 to 12.Type: GrantFiled: June 7, 1995Date of Patent: October 7, 1997Assignee: Rhone-Poulenc Chemicals LimitedInventors: Ian Michael Hawkins, Heiko Heinrich Karl Mauermann
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Patent number: 5663307Abstract: Novel compounds of the formula ##STR1## where G.sup.1 and G.sup.2 are each independently --OH or --N(R.sup.2).sub.2, provided that at least one of G.sup.1 and G.sup.2 is --N(R.sup.2).sub.2, where each R.sup.2 is independently hydrogen, alkyl, aryl, acyl or --(A).sub.p --R.sup.a and the other variables are as defined in the specification and claims, and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: September 2, 1997Assignee: Bracco International B.V.Inventors: David P. Nowotnik, Palaniappa Nanjappan
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Patent number: 5660811Abstract: An isotopic tracer composition and methods of making and using same for radiological evaluation of body functions and diseases in a subject and for radiological therapy. The isotopic tracer composition comprises a protein carrier agent such as fibrinogen, antibodies, enzymes or portions thereof, bound to a radioisotope which has been reduced to a lower oxidation state by stannous phosphate at a pH of greater than 7. Some suitable radioisotopes are isotopes of technetium, rhenium and ruthenium.Type: GrantFiled: May 30, 1995Date of Patent: August 26, 1997Assignee: The Board of Regents of the University of OklahomaInventor: Stanley L. Mills
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Patent number: 5651954Abstract: Novel compounds of the formula ##STR1## where G.sup.1 and G.sup.2 are each independently --OH or --N(R.sup.2).sub.2, provided that at least one of G.sup.1 and G.sup.2 is --N(R.sup.2).sub.2, where each R.sup.2 is independently hydrogen, alkyl, aryl, acyl or --(A).sub.p --R.sup.a and the other variables are as defined in the specification and claims, and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.Type: GrantFiled: June 6, 1995Date of Patent: July 29, 1997Assignee: Bracco International B.V.Inventors: David P. Nowotnik, Palaniappa Nanjappan
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Patent number: 5648532Abstract: Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.Type: GrantFiled: June 3, 1993Date of Patent: July 15, 1997Assignee: The Regents of the University of CaliforniaInventors: M. Frederick Hawthorne, Debra Arliene Feakes, Kenneth John Shelly
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Patent number: 5645818Abstract: The invention relates to ligands having the formula (I), in which X represents a heterocyclic group, together with the process for their preparation. The invention also concerns mono- or polymetallic complexes formed by said ligands with metallic ions selected from lanthanide ions, transition metal ions, barium ion, bismuth ion, lead ion and the radioisotopes 99m.sub.Tc, 111.sub.In, 90.sub.Y, 64.sub.Cu and 169.sub.Yb, as well as salts physiologically acceptable to these complexes. The salts of said complexes can be used as diagnostic and therapeutic agents in magnetic resonance imaging, radiology, in vivo chemical displacement agents and in nuclear medicine.Type: GrantFiled: January 12, 1995Date of Patent: July 8, 1997Assignees: Guerbet S.A., Wake Forest UniversityInventors: Susan C. Jackels, Dominique Meyer
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Patent number: 5645814Abstract: The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 18, 1994Date of Patent: July 8, 1997Assignee: Mallinckrodt Medical, Inc.,Inventors: Steven R. Woulfe, Raghavan Rajagopalan
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Patent number: 5639879Abstract: A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.Type: GrantFiled: February 2, 1995Date of Patent: June 17, 1997Assignee: Associated Universities, Inc.Inventors: Ronnie C. Mease, Leonard F. Mausner, Suresh C. Srivastava
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Patent number: 5635157Abstract: Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.Type: GrantFiled: October 6, 1993Date of Patent: June 3, 1997Inventors: Ronnie C. Mease, Kathryn L. Kolsky, Leonard F. Mausner, Suresh C. Srivastava
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Patent number: 5633372Abstract: The present invention relates particularly to novel heterocycle based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 10, 1995Date of Patent: May 27, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, Ananthachari Srinivasan
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Patent number: 5623077Abstract: The present invention relates particularly to novel imidazole based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 10, 1995Date of Patent: April 22, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, Ananthachari Srinivasan