Patents Examined by Laura R. Cross
  • Substituted histidines
    Patent number: 5565480
    Abstract: Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: October 15, 1996
    Assignee: SmithKline Beecham Corporation
    Inventors: John G. Gleason, Judith Hempel, David T. Hill, James Samanen, Joseph Weinstock
  • Condensed thiazole derivative, production process thereof and pharmaceutical composition thereof
    Patent number: 5565479
    Abstract: Condensed thiazole derivatives useful as 5-HT.sub.3 receptor agonists are provided and can be represented by the following formula (I) or a pharmaceutically acceptable salt thereof, a process for the production thereof and a pharmaceutical composition thereof: ##STR1## wherein R, A, L.sub.1, L.sub.2, L, and R.sup.1 -R.sup.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: October 15, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kiyoshi Iwaoka, Hiroyuki Koshio, Hiroyuki Ito, Keiji Miyata, Mitsuaki Ohta
  • (2-imidazolin-2-yl) fused heteropyridine compounds, intermediates for the preparation of and use of said compounds as herbicidal agents
    Patent number: 5565412
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 15, 1996
    Assignee: American Cyanamid Co.
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • (2-imidazolin-2-yl) fused heteropyridine compounds, intermediates for the preparation of and use of said compounds as herbicidal agents
    Patent number: 5565411
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 15, 1996
    Assignee: American Cyanamid Co.
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Process for preparing benzyl-substituted rhodanine derivatives
    Patent number: 5563277
    Abstract: The instant invention provides a novel process for preparing benzyl-substituted rhodanine derivatives. The process is particularly useful for synthesizing the enantiomers of such derivatives. Also provided are novel benzyl-substituted mercaptopropanoic acids and benzyl-substituted thiazolidinones. Such compounds are useful for treating inflammatory bowel disease and, accordingly, the present invention provides a method of treating inflammatory bowel disease in mammals utilizing such novel compounds as well as pharmaceutical compositions containing same.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: October 8, 1996
    Assignee: Eli Lilly and Company
    Inventors: Marvin M. Hansen, Allen R. Harkness, Michael J. Martinelli, Vien V. Khau
  • 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5563163
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 8, 1996
    Assignee: Sterling Winthrop, Inc.
    Inventors: Richard P. Dunlap, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam, John J. Court, Malcolm R. Bell, Virendra Kumar
  • (2-imidazolin-2-yl) fused heteropyridine compounds, intermediates for the preparation of and use of said compounds as herbicidal agents
    Patent number: 5563113
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 8, 1996
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Aliphatic amino bis-aryl squalene synthase inhibitors
    Patent number: 5561143
    Abstract: This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: October 1, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Robert A. Groneberg, John R. Regan, Kent W. Neuenschwander, Anthony C. Scotese
  • Stable liquid compositions and their use
    Patent number: 5558816
    Abstract: Stable composition of 1,2-benzisothiazolin-3-one (BIT) in dipropylene glycol having lower pH and lower viscosity than known compositions. The BIT is present as an alkali metal salt obtained by reacting 0.75 to 1.07 moles alkali metal hydroxide with one mole BIT.
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: September 24, 1996
    Assignee: Zeneca Limited
    Inventor: John D. Payne
  • Silver halide photographic light-sensitive material
    Patent number: 5559240
    Abstract: A silver halide photographic light-sensitive material contains a methine compound represented by the following formula: ##STR1## wherein Y.sup.1 is a group which is clearable by a nucleophile; Z.sup.1 is --O--, --S-- or other; Z.sup.2 is --S--; A and B are each independently hydrogen, halogen, alkyl, aryl or a heterocyclic group; A and B may be linked to each other to form an unsaturated aliphatic ring or an aromatic ring; and Q.sup.1 is a methine or polymethine group which may have a heterocyclic group. A novel methine compound is also disclosed.
    Type: Grant
    Filed: December 6, 1994
    Date of Patent: September 24, 1996
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Ken Kawata, Tadashi Ikeda
  • N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
    Patent number: 5554636
    Abstract: The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group, of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: September 10, 1996
    Assignee: LSU Medical Center Foundation
    Inventors: Nicolas G. Bazan, Julio Alvarez-Builla Gomez
  • Liquid isothiazolinone concentrates having improved low temperature-stability and improved anti-bacterial properties
    Patent number: 5554635
    Abstract: A liquid concentrate comprises between about 4 and about 10 wt % of an isothiazolinone compound or mixture of isothiazolinone compounds, between about 25 and about 92 wt % of a plasticizer in which said isothiazolinone compound is soluble and between about 4 and about 50 wt % of 2,4,4'-trichloro-2'-hydroxydiphenyl ether. The 2,4,4'-trichloro-2'-hydroxydiphenyl ether stabilizes the concentrate against crystallization and/or freezing at sub-freezing conditions, particularly when the isothiazolinone compound has a melting point of 30.degree. C. or above. 2,4,4'-trichloro-2'-hydroxydiphenyl ether also enhances the anti-microbial properties of an isothiazolinone-containing concentrate.
    Type: Grant
    Filed: February 7, 1995
    Date of Patent: September 10, 1996
    Assignee: Morton International, Inc.
    Inventors: Nuno M. Rei, Roger G. Hamel
  • (2-imidazolin-2-yl) fused heteropyridine compounds, intermediates for the preparation of and use of said compounds as herbicidal agents
    Patent number: 5554579
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 10, 1996
    Assignee: American Cyanamid Co.
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them
    Patent number: 5547967
    Abstract: 3-(Phenylalkylaminoalkylozy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are described. The compounds correspond to the general formula I ##STR1## or to the general formula XXXI ##STR2## in which the substituents have the meanings given the specification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 20, 1996
    Assignee: Kali-Chemie Pharma GmbH
    Inventors: Wolfgang Kehrbach, Michael Mlinaric, Dieter Ziegler, Reinhard Brueckner, Willi Bielenberg
  • Surface supported cobalt catalysts, process utilizing these catalysts for the preparation of hydrocarbons from synthesis gas and process for the preparation of said catalysts
    Patent number: 5545674
    Abstract: A supported particulate cobalt catalyst is formed by dispersing cobalt, alone or with a metal promoter, particularly rhenium, as a thin catalytically active film upon a particulate support, especially a silica or titania support. This catalyst can be used to convert an admixture of carbon monoxide and hydrogen to a distillate fuel constituted principally of an admixture of linear paraffins and olefins, particularly a C.sub.10+ distillate, at high productivity, with low methane selectivity. A process is also disclosed for the preparation of these catalysts.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: August 13, 1996
    Assignee: Exxon Research and Engineering Company
    Inventors: William C. Behrmann, Kym B. Arcuri, Charles H. Mauldin
  • N-polyhalobenzyl-pyrazole carboxamides endowed with acaricidal and insecticidal activity
    Patent number: 5541214
    Abstract: Amides of pyrazolecarboxy acids having the general formula (I): ##STR1## exhibiting a high insecticidal and acaricidal activity.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: July 30, 1996
    Assignee: Isagro S.p.A.
    Inventors: Franco Bettarini, Giovanni Meazza, Piero La Porta, Giampaolo Zanardi, Sergio Massimini, Franca Reggiori
  • CC-1065 analogs having two CPI subunits
    Patent number: 5541339
    Abstract: This invention concerns chemical compounds of general Formula ICPI.sub.1 -R.sub.5 -T-R'.sub.5 -CPI.sub.2 IThe compounds of Formula I are useful as uv light absorbers, antibacterial agents, and are particularly useful as antitumor agents. Representative compounds of Formula I have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: July 30, 1996
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, Paul A. Aristoff
  • High affinity chelates containing isothiocyanate groups, useful for coupling with peptides and proteins
    Patent number: 5539138
    Abstract: The ligands HBED-SCN, HBPD-SCN, and HTDD-SCN are provided which have enhanced ease of reaction with peptides or proteins and which are suitable for chelating with radioisoptopes, especially Indium-.sup.III and Gallium-.sup.67.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: July 23, 1996
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Richard J. Flanagan, Keith T. Hogan, Jean-Marc Dufour, F. Peter Charleson
  • Acylamino-substituted isoxazole or isothiazole derivatives, their preparation and their use
    Patent number: 5538939
    Abstract: Acylamino-substituted isoxazole or isothiazole derivatives of the formula I ##STR1## where X is oxygen or sulfur;R.sup.1 is unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or phenyl;R.sup.2 is CN, CONH.sub.2, CSNH.sub.2, or haloalkyl;R.sup.3 is hydrogen or unsubstituted or substituted alkyl or cycloalkyl;R.sup.4 is alkoxy, unsubstituted or substituted alkyl, cycloalkenyl, cycloalkyl, alkenyl or alkynyl, an unsubstituted or substituted 5-membered or 6-membered heterocyclic radical or unsubstituted or substituted phenyl;haloalkyl, alkoxy, haloalkoxy, alkylthio and/or haloalkylthio,and agriculturally useful salts of the isoxazole or isothiazole derivatives I, useful as herbicides.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: July 23, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Muenster, Ernst Schefczik, Hartmann Koenig, Matthias Gerber, Karl-Otto Westphalen, Helmut Walter
  • (2-Imidazolin-2-yl) fused heteropyridine compounds
    Patent number: 5536839
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 16, 1996
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson