Abstract: A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.
Type:
Grant
Filed:
August 2, 1993
Date of Patent:
June 28, 1994
Assignees:
Cygnus Therapeutic Systems, The Regents of the University of California
Inventors:
Durairaj Bommannan, Hirohisa Okuyama, Richard H. Guy, Paul Stauffer, Gordon L. Flynn