Abstract: A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominatly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
Type:
Grant
Filed:
October 13, 1988
Date of Patent:
February 13, 1990
Assignee:
Alza Corporation
Inventors:
Yu-Ling Cheng, Robert M. Gale, Edna Sugihara, Harold F. Sanders