Abstract: A medical device for detecting at least one analyte in a body fluid, a method for assembling the medical device and a method of using the medical device are disclosed. The medical device comprises: an analyte sensor having an insertable portion; an insertion cannula receiving the insertable portion of the analyte sensor; an electronics unit connected with the analyte sensor; and a housing comprising an electronics compartment receiving the electronics unit and a sensor compartment receiving the analyte sensor, the sensor compartment forming a sealed compartment receiving the insertable portion of the analyte sensor, the sealed compartment comprising detachable upper and lower caps, the lower cap configured for detachment before insertion, the insertion cannula being attached to the upper cap, wherein detaching the upper cap after insertion removes the insertion cannula, wherein the electronics compartment at least partially surrounds the sensor compartment.

Abstract: An apparatus for estimating blood pressure is provided. The apparatus for estimating blood pressure may include: a bio-signal measurer configured to measure a bio-signal from a user; and a processor configured to extract one or more feature values from the bio-signal, to adjust a combination coefficient for combining the one or more feature values based on a reference value associated with vascular compliance, and to estimate blood pressure based on the adjusted combination coefficient, and the one or more feature values extracted from the bio-signal.

Abstract: Embodiments of the invention provide optimized sputtered metallic surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These sputtered metallic surfaces have features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a sputtered metallic surface adapted to contact an in vivo environment.

Abstract: A contact assembly for electrically interconnecting at least two modules is disclosed. The contact assembly has a first module having a first contact pad and a second module having a second contact pad. The first and second contact pads are arranged nonparallel to one another. One of the first and second contact pads exerts pressure on an electrically conductive elastomer to thereby deform it, and the deformation results in the other one of the first and second contact pads being contacted by the electrically conductive elastomer. An electrochemical sensor may be part of the first module and an electronics assembly may be part of the second module. An insertion needle may also be provided to insert the sensor transcutaneously. Associated methods are disclosed.

Abstract: Systems and methods for monitoring eyedrop usage are disclosed. Example embodiments include a system to monitor eyedrop usage. The system may include a detection and activation circuit couplable to a wireless biosensor and an eyedrop dispenser. The detection and activation circuit may include a pressure transducer that transmits a signal upon detecting a force at, or above, a threshold value. The system may also include a wireless biosensor insertable into a region of an eyelid. The wireless biosensor may include a sensor to detect the physical change and the chemical change of tears as a result of eyedrop usage. The wireless biosensor may also include a transceiver to receive the signal that activates the sensor for an activation time.

Abstract: The present invention relates to a method and system for calculating eating bites of a user. The method comprises: (a) continuously measuring the electrical properties data of mastication of a user for a predetermined period of time; (b) periodically determining single eating bites according to the data obtained in step (a) through a time interval; (c) periodically storing the bites determined throughout the predetermined period of time, through a time interval.

Abstract: An injection sensing device (ISD) (e.g., wearable patch) is paired with an external device (e.g., a medication delivery pen and/or smart phone, iPad, computer) via wireless link or wireline connection. The ISD senses fluctuations in local skin temperature during an injection and provides to the external device captured data from the sensor relating to medicine delivery to a patient to ensure complete delivery and minimize MDD misuse or malfunction or inaccuracies in dosing. The ISD or external device can use captured data and corresponding time stamps to determine flow informatics such as flow rate, total dose delivered, and dose completion status. An LED on the ISD indicates delivery in progress and/or delivery completion.

Abstract: Systems and methods for evaluating patients are provided. An example includes receiving first cardiopulmonary exercise test data for the patient and plotting a first vector based on the first cardiopulmonary exercise test data, the first vector including a first point based on a rest value and a second point based on an exercise value. A first coordinate value of the first point and a first coordinate value of the second point may be based on mixed expired CO2 (PECO2) and a second coordinate value of the first point and a second coordinate value of the second point may be based on end tidal CO2 (PetCO2). The example may also include plotting a midpoint of the first vector and triggering display of the plotted vector and plotted midpoint. The plotted vector and plotted midpoint may be displayed over a coordinate grid having multiple physiological condition zones.

Abstract: Systems and methods are provided for adjusting a standing insulin medicament dosage regimen for a subject. Fasting events are identified using autonomous timestamped glucose measurements of the subject in a first data set. A second data set, from one or more insulin pens used to apply the standing regimen, comprises records, each record comprising a timestamped event specifying an amount of injected insulin medicament. Each fasting event is characterized as adherent or nonadherent. A fasting event is adherent when the second data set includes one or more records that temporally and quantitatively establish adherence with the standing regimen during the fasting event. Conversely, a fasting event is nonadherent when the second data set fails to temporally and quantitatively establish adherence with the standing regimen.

Abstract: Various examples are directed to systems and methods for monitoring a patient. For example, patient data of a first type may be monitored with a low-fidelity monitoring technique over a first time period. Patient behavior may be evaluated based on the monitored first type of patient data. Patient data of a second type may be monitored over a second time period with a continuous glucose monitor device. A parameter of the continuous glucose monitor device may be based on the evaluated patient behavior during the monitoring.

Abstract: A method for processing a neural measurement obtained in the presence of artifact, in order to detect whether a neural response is present in the neural measurement. A neural measurement is obtained from one or more sense electrodes. The neural measurement is correlated against a filter template, the filter template comprising at least three half cycles of an alternating waveform, amplitude modulated by a window. From an output of the correlating, it is determined whether a neural response is present in the neural measurement.

Abstract: Disclosed is a non-invasive system for testing blood sugar and a method of the same. The system includes a case, a control key unit, an input electrode unit, a signal filter unit, a signal transformation unit, a control processing unit, a signal amplification unit, an output electrode unit, a driver, a display unit, and a battery unit for preliminarily testing and instantly showing blood sugar or glucose in a non-invasive manner. Owing to a simple structure without any additional device or connection wire, the system is easy to use and practical to assist the user to readily test blood sugar. As a result, the present invention effectively avoids any potential risk of infection of bacteria or other microorganism due to frequently sampling the blood by pricking the finger, and particularly provides a function of fast and readily testing blood sugar everywhere for long term monitoring.

Abstract: An apparatus for estimating blood pressure is provided. The apparatus for estimating blood pressure may include: a bio-signal measurer configured to measure a bio-signal from a user; and a processor configured to extract one or more feature values from the bio-signal, to adjust a combination coefficient for combining the one or more feature values based on a reference value associated with vascular compliance, and to estimate blood pressure based on the adjusted combination coefficient, and the one or more feature values extracted from the bio-signal.

Abstract: An apparatus for estimating bio-information may include: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to extract one or more first feature values from the bio-signal, determine a scale factor based on the first feature values, and to estimate bio-information based on the scale factor and the first feature values.

Abstract: Provided are a method of generating a respiratory status classifier and a method of determining respiratory status. The method of generating a respiratory status classifier includes segmenting collected respiratory signals according to respiratory cycles, acquiring data pairs of a calculated power spectrum of frequency components and a designated respiratory status indication value for a plurality of cycle-specific respiratory signals selected from among the segmented cycle-specific respiratory signals, selecting specific frequency components from among the frequency components, inputting data pairs of a power spectrum and a designated respiratory status indication value corresponding to the specific frequency components to a respiratory status classifier, and training the respiratory status classifier according to output values from the classifier.

Abstract: As described herein, a system includes an optical sensor, and a controller that detects progression of obstructive coronary artery disease using a sensor signal from the optical sensor. For example, the system is used for detecting an occlusion in a cardiovascular system of a user. A computer-implemented method for detecting the occlusion includes generating a light within a predetermined spectral range, the light directed towards a reflective element at a predetermined angle. The method further includes receiving a reflected light caused by a reflection of the light off of a reflecting element that is in contact with the user's epidermis. The method further includes detecting a concentration of a predetermined biomarker in a biofluid in the cardiovascular system based on variations in amplitude of the reflected light. The method further includes determining an occlusion in the cardiovascular system based on the concentration of the predetermined biomarker.

Abstract: The invention relates to a patch (2) with at least one filler and at least one active ingredient, wherein the local distribution of the active ingredient or ingredients within the patch (2) takes place dependent on the morphology, anatomy and physiology of the lesion (1) to be treated.

Abstract: A semiconductor device includes an antenna mounted on a wiring substrate. A holding member includes a first plate-shaped part having a first surface and a second surface, a second plate-shaped part having a third surface and a fourth surface, and a coupling part configured to couple the first plate-shaped part and the second plate-shaped part so that the second surface and the third surface have parts facing each other with a space therebetween. The one end of the wiring substrate is fixed to the holding member so that the antenna overlaps the coupling part, as seen from above. A part continuing to the one end of the wiring substrate is folded back so as to being arranged sequentially along the first surface, the second surface, the third surface, and the fourth surface. The other end of the wiring substrate extends in an elastically deformable state from the fourth surface.