Patents Examined by Liban Hassan
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Patent number: 9816067Abstract: An automated biological growth and dispensing apparatus utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for agitation may be integral and removable with the growing tank or may be adapted for a quick connection and disconnection with the growing tank. The growing tank may be disposable and each new growing tank may be provided as a sealed container including a starting amount of a biomass and/or nutrient.Type: GrantFiled: March 14, 2014Date of Patent: November 14, 2017Assignee: OP-Hygiene IP GmbHInventor: Heiner Ophardt
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Patent number: 9810707Abstract: Portable systems for processing and analyzing biological or environmental samples as well as different configurations of chip-based flow cytometers are provided. The portable systems include an automated assay preparation module configured to process a sample into a fluid assay with fluorescently tagged particles and a microfluidic analysis module coupled to the fluid assay module, wherein the microfluidic analysis module includes a chip-based flow cytometer.Type: GrantFiled: May 17, 2007Date of Patent: November 7, 2017Assignee: LUMINEX CORPORATIONInventors: Adam Richard Schilffarth, William R. Deicher, John C. Carrano, Jesse C. Phillips
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Patent number: 9778277Abstract: An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); a plurality of spinners (63) for spinning the dishes (60); a plurality of suction cups (62) for placing a lid (600) on each of the dishes; and a plurality of laterally arranged belts (64,65) for transporting the closed dishes (60) to an intermediate storage (8).Type: GrantFiled: March 19, 2010Date of Patent: October 3, 2017Assignee: F. Hoffmann-La Roche AGInventors: Dieter Voegelin, Patrick Iaiza, Thomas Zumstein, Tom Kissling
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Patent number: 9752112Abstract: The pressure and circulation culture apparatus includes a holder (culture chamber part), a pressure transmission part and a culture solution circulation line (culture circuit). The holder reserves culture solution and holds a cultured object. The pressure transmission part communicates with the holder and transmits an external pressure to the culture solution. The culture solution circulation line is connected to the holder via the pressure transmission part, and circulates the culture solution through the holder via the pressure transmission part. Such a structure is included, and an external pressure is made to operate on the culture solution via the pressure transmission part to allow pressure on the cultured object in the holder and circulation of the culture solution in the holder.Type: GrantFiled: February 23, 2012Date of Patent: September 5, 2017Assignee: PURPOSE CO., LTD.Inventors: Setuo Watanabe, Toshimi Murata, Mituharu Satou, Ibuki Kinouchi, Hidetada Takai
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Patent number: 9738887Abstract: A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region.Type: GrantFiled: February 13, 2013Date of Patent: August 22, 2017Assignee: NeuMoDx Molecular, Inc.Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner
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Patent number: 9670453Abstract: Disclosed is a system for dissociating a sheet-shaped cell culture into individual cells. The system, so configured as to minimize the amount of damage to cells when dissociating a sheet-shaped cell culture into individual cells, in one form includes: (i) a reaction unit that dissociates the sheet-shaped cell culture; (ii) a sensor unit that acquires information relating to a particle size distribution of cells inside the reaction unit; and (iii) an analysis unit that computes the particle size distribution of the cells from the information acquired by the sensor unit and determines and outputs a dissociation state.Type: GrantFiled: January 29, 2013Date of Patent: June 6, 2017Assignee: TERUMO KABUSHIKI KAISHAInventor: Takashi Yamamoto
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Patent number: 9637733Abstract: A reagent supply device includes a plurality of chambers which are separated from each other such that different reagents may be injected, the plurality of chambers having bottom surfaces made of a membrane, the membrane comprising a destruction pattern which is formed at a position corresponding to each of the plurality of chambers and breachable by an external impact to discharge the injected reagent from the chamber.Type: GrantFiled: June 13, 2013Date of Patent: May 2, 2017Assignee: SAMSUNG ELECTRONICS CO., LTD.Inventors: Chin-sung Park, Kak Namkoong, Joon-sub Shim, Won-seok Chung, Kyung-ho Kim, Joon-ho Kim, Won-jong Jung
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Patent number: 9637714Abstract: A scalable photobioreactor system for efficient production of photosynthetic microorganisms such as microalgae and cyanobacteria is described. In various embodiments, this system may include the use of extended surface area to reduce light intensity and increase photosynthetic efficiency, an external water basin to provide structure and thermal regulation at low cost, flexible plastic or composite panels that are joined together make triangular or other shapes in cross-section when partially submerged in water, use of positive gas buoyancy and pressure to maintain the structural integrity of the photobioreactor chambers and use of structure to optimize distribution of diffuse light. Other embodiments concern air tubes comprised of plastic film at the bottom of each photobioreactor chamber to provide sparging air bubbles to the chamber. The photobioreactor system design also comprises gas exchange, temperature control, air pumping, liquid pumping, filtration, media recycling and harvesting methods.Type: GrantFiled: October 12, 2007Date of Patent: May 2, 2017Assignee: Colorado State University Research FoundationInventors: Bryan Willson, Guy Babbitt, Christopher Turner, Peter Letvin, Kristina Weyer-Geigel, Anna Ettinger, Amy Boczon, Nicholas Rancis, James Murphy
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Patent number: 9623415Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: GrantFiled: December 30, 2015Date of Patent: April 18, 2017Assignee: Click Diagnostics, Inc.Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam de la Zerda, Jesus Ching, Colin Kelly, Steven Chu, David Swenson, Helen Huang
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Patent number: 9605239Abstract: An attachment arrangement for providing a sensor in a flexible bag, said attachment arrangement comprising: a sensor holding part adapted to be integrated with the flexible bag and comprising first locking part protruding out form the flexible bag, the sensor holding part holding an optical sensor inside the flexible bag; an adaptor part provided outside the flexible bag and adapted to hold an optical fiber, the adaptor part comprising second locking part adapted to mate with the first locking part to lock the first locking part and the second locking part together such that the optical fiber can communicate with the optical sensor inside the bag.Type: GrantFiled: December 15, 2010Date of Patent: March 28, 2017Assignee: GE Healthcare Bio-Sciences ABInventors: Hanno Ehring, Kine Frej, Owe Salven, Anders Wilen
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Patent number: 9550969Abstract: An inflatable bioreactor bag for cell cultivation, which comprising a top and a bottom sheet of flexible material, joined together to form two end edges and two side edges, wherein one baffle or a plurality of baffles extend from the bottom sheet in a region where the shortest distance to any one of the two end edges is higher than about one fourth of the shortest distance between the two end edges.Type: GrantFiled: March 16, 2012Date of Patent: January 24, 2017Assignee: GE Healthcare Bio-Sciences ABInventors: Veronique Chotteau, Rafael Diana, Christian Kaisermayer, Eva Lindskog, Craig Robinson, Jimmie L. Rucker, Kieron D. Walsh
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Patent number: 9534245Abstract: A method and device for controlling a fermenting process, wherein the method comprises collecting samples of biological cells from a fermenting tank, obtaining the state information of the current biological cells based on the collected samples, comparing the state information of the current biological cells with preset target status information to obtain the difference between the state information of the current biological cells and preset target state information, and controlling the feed rate of nutritional solution into the fermenting tank. Real time control of biological fermenting process is thus accomplished based on the state information of the biological cells during fermentation, and the consistency during fermentation is improved. Complicated mathematical modeling and man-made data analysis are not required for the method and device.Type: GrantFiled: April 23, 2008Date of Patent: January 3, 2017Assignee: Siemens AktiengesellschaftInventors: Kurt Dirk Bettenhausen, Shun Jie Fan, Herbert Grieb, Jun Feng Jiang, Hongwei Yang, Yue Zhuo
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Patent number: 9534800Abstract: Techniques described herein are generally related to a biofilter for living spaces. The biofilter may include an organic biofilter medium to serve as a growth base for both plants and one or more microbial colonies. Example embodiments include systems, articles, methods and apparatus, as well as other embodiments that are described and claimed.Type: GrantFiled: August 27, 2010Date of Patent: January 3, 2017Assignee: Empire Technology Development LLCInventor: Ezekiel Kruglick
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Patent number: 9388374Abstract: In one embodiment, a microfluidic structure comprises a culture chamber having an object flow inlet disposed between a pair of object flow outlets. A flow-around channel provides fluidic mass transport to the culture chamber through a perfusion barrier disposed opposite from the object flow inlet and object flow outlets. The perfusion barrier surrounds the culture chamber, defines an opposite wall of the culture chamber, and prevents cell passage into the flow around-channel. The perfusion barrier creates a low fluidic resistance path within the culture chamber, such that a flow of cells entering the culture chamber from the object flow inlet encounters a flow of media passing through the perfusion barrier. This causes the cells to take an approximately 180 degree turn and exit the culture chamber via the object flow outlets. The low fluidic resistance path allows the cells to settle onto the chamber floor without needing any physical barrier.Type: GrantFiled: January 21, 2011Date of Patent: July 12, 2016Assignee: EMD Millipore CorporationInventors: Paul J. Hung, Philip J. Lee
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Patent number: 9382511Abstract: A bioreactor outlet air conditioning system (10) has a bioreactor vessel (100) and a heat exchanger. The heat exchanger has a fluid flow path (196) from a headspace (108) in the vessel for venting air from the vessel, and a temperature control element (300) in thermal contact with the fluid flow path (196). The fluid flow path (196) may be defined by a disposable portion of the bioreactor vessel (100). A method of controlling evaporation within a bioreactor vessel (100), dependent on the required evaporation rate, adjusts the temperature of the temperature control element (300) to control the rate of evaporation of the liquid media (106) from the vessel (100), and may include monitoring fluids in the fluid flow path (196) to detect at least water content of the fluids exiting the vessel to adjust the temperature and control the rate of evaporation dependent on the detected water content levels.Type: GrantFiled: October 25, 2012Date of Patent: July 5, 2016Assignee: TAP BIOSYSTEMS (PHC) LIMITEDInventor: Adrian Neil Bargh
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Patent number: 9346054Abstract: Disclosed is a non-contact heating type gene amplification system. The non-contact heating type gene amplification system includes separate light sources for each step of a polymerase chain reaction in order to perform a high-speed temperature cycle by moving a rotation unit, in which a plurality of sample chambers are formed, to places at which the sample chambers are controlled at the temperatures corresponding to each step.Type: GrantFiled: November 15, 2010Date of Patent: May 24, 2016Assignee: KOREA FOOD RESEARCH INSTITUTEInventors: Hyang Sook Chun, Sung Wook Choi, Na Ri Lee, Hyun Joo Chang
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Patent number: 9267616Abstract: At least one embodiment of the invention relates to an arrangement for thermocyclization of a substance. At least one embodiment of the invention also relates to a method for the thermocyclization of a substance, including: the controllable valves automatically close the PCR chamber after the test fluid has been introduced into the PCR-chamber, and the properties for the memory metal or bimetal elements are used for closing the valves when a predetermined temperature has been exceeded. As a result, the mechanical actuator, which is used to actuate the valves, is thermally coupled to the heating/cooling element in order to carry out the thermocyclization.Type: GrantFiled: October 14, 2005Date of Patent: February 23, 2016Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Walter Gumbrecht, Peter Paulicka, Manfred Stanzel
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Patent number: 9238226Abstract: The invention relates to a three-part rack for holding re-usable pipette tips. The rack comprises an upper, a lower and an insert rack. The rack is optimized for holding first and second types of pipette tips, and comprises contamination protection.Type: GrantFiled: December 9, 2010Date of Patent: January 19, 2016Assignee: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Renato Belz, Christian Thalmann
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Patent number: 9228166Abstract: Biocontainers, as well as methods and platforms for rocking the biocontainers, are disclosed.Type: GrantFiled: December 20, 2011Date of Patent: January 5, 2016Assignee: Pall CorporationInventors: Timothy Alan Barrett, Alison Jane West, Kenneth Roy Weight, Adam Peter Westwood, Daniel James Kesselaar
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Patent number: 9113624Abstract: A system for perfusing a biological organ for use as an experimental model includes a housing having sides that define a cavity for containing a biological organ model within a solution. The housing includes a plurality of apertures defined therethrough configured to mechanically interface with a filter, one or more heating elements and one or more sensors. A peristaltic pump is configured to withdraw and pressurize the solution from the housing and reintroduce the solution under pressure into the biological organ. A heat control module operatively connects to the heating elements and is configured to regulate the temperature of the solution within the housing. A data acquisition system operatively connects to the heat control module, the peristaltic pump and the sensor(s) and regulates and monitors the pressure, flow rate and temperature of the solution during electrical treatment of the biological organ.Type: GrantFiled: October 15, 2008Date of Patent: August 25, 2015Assignee: Covidien LPInventors: Anna Belous, Tom E. McMunigal, Ronald J. Podhajsky, Jeffrey A. Hammond