Abstract: The isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a portein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-IIIB cell line from viral genomes of related viruses.
Type:
Grant
Filed:
July 25, 1990
Date of Patent:
November 5, 1991
Assignee:
The United States of America as represented by the Department of Health & Human Services
Inventors:
Flossie Wong-Stal, Pranab K. Chanda, John Ghrayeb