Abstract: A gelled oil composition containing an emulsifier, a gelling agent, an oil, and a surfactant which, when applied to the skin in the presence of water, produces a significant amount of foam. After the composition is rinsed from the skin, a non-greasy, oil residue is left thereon.
Type:
Grant
Filed:
May 26, 2000
Date of Patent:
February 25, 2003
Assignee:
Johnson & Johnson Consumer Companies, Inc.
Inventors:
Delores M. Santora, John Hopkins, Laura J. McCulloch
Abstract: A method of pulmonary delivery of a medicament, for example a dopamine precursor or a dopamine agonist, which includes administering to the respiratory tract of a patient in need of rescue therapy particles comprising an effective amount of a medicament. The particles are delivered to the pulmonary system and are released into the blood stream and delivered to the medicament's site of action in a time sufficiently short to provide the rescue therapy. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others. Preferred particles have a tap density of less than about 0.4 g/cm3.
Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.
Type:
Grant
Filed:
February 18, 2000
Date of Patent:
January 28, 2003
Assignee:
SmithKline Beecham Corp.
Inventors:
Ian C. Ashurst, Ignatius Loy Britto, Craig Steven Herman, Li Li-Bovet, Michael Thomas Riebe
Abstract: A threadlike or ribbonlike elastic strand is provided with a substantially continuous filament of adhesive helically wrapped around the elastic strand. The elastic strand is suitable for use in disposable absorbent products such as diapers and adult incontinent products. Also disclosed is a method and apparatus for making such adhesive-wrapped elastic strands.
Type:
Grant
Filed:
April 26, 1995
Date of Patent:
January 21, 2003
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Neal Alan Rollins, John Anthony Rooyakkers
Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
Type:
Grant
Filed:
December 19, 2001
Date of Patent:
January 7, 2003
Assignee:
Alcon Manufacturing, Ltd.
Inventors:
Masood Chowhan, Nissanke L. Dassanayake
Abstract: The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent. The membrane can be used to deliver biologically active agents to the skin.
Type:
Grant
Filed:
April 13, 2000
Date of Patent:
December 24, 2002
Assignee:
Color Access, Inc.
Inventors:
Jules Zecchino, E. Althea Knight, Carmen Castillo-Bucci
Abstract: A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption enhancer is adapted to modify the surface membrane such that absorption through the surface membrane is initiated or increased. The oral-absorption enhancer may comprise hydroxypropyl-beta-cyclodextrin and surfactants including benzalkonium chloride, benzethonium chloride, polysorbate 80, sodium lauryl sulfate, Brij surfactants, Tween and Pluronic surfactants. Also disclosed is a system for delivering the formulation including a mechanism for dispensing predetermined doses of the inventive formulation intra-orally as with an aerosol or spray pump or propellant device.
Type:
Grant
Filed:
August 30, 2001
Date of Patent:
December 17, 2002
Inventors:
Randall McCoy, Robert O. Williams, III, Miles A. Libbey, III
Abstract: A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.
Type:
Grant
Filed:
June 2, 2000
Date of Patent:
November 26, 2002
Assignee:
DelRx Pharmaceutical Corp.
Inventors:
Randall McCoy, Miles Augustus Libbey, III, Jle Liu, Robert O. Williams, III
Abstract: A modulated release aerosol formulation is disclosed. The formulation comprises a polymer, e.g. Silica gel, fumed silica gel, having a selected medicament associated therewith, and a fluid carrier for carrying and delivering the construct.
Abstract: The present invention concern a cosmetic composition for topical application for reactivating the physiological growth of hair, said composition comprising a synergistic association of cysteine, lysine or derivatives thereof, with a glycoprotein, in a physiologically acceptable vehicle.
Abstract: A modulated release aerosol formulation is disclosed. The formulation comprises a polymer, e.g. Silica gel, fumed silica gel, having a selected medicament associated therewith, and a fluid carrier for carrying and delivering the construct.
Type:
Grant
Filed:
February 15, 2001
Date of Patent:
November 5, 2002
Assignee:
Aeropharm Technology Incorporated
Inventors:
Yaping Zhu, Simon G. Stefanos, Lukeysha Kline, Akwete L. Adjei
Abstract: The invention relates to compositions for washing keratin materials, comprising, in a cosmetically acceptable medium containing at least one anionic detergent surfactant, at least one oxyethylenated sorbitan ester of a C8-C30 fatty acid with a number of moles of ethylene oxide of less than or equal to 10. These compositions have a weight ratio anionic detergent surfactant agent/sorbitan ester of C8-C30 fatty acid ranging from 0.5 to 5.
Type:
Grant
Filed:
January 11, 2001
Date of Patent:
November 5, 2002
Assignee:
L'Oreal
Inventors:
Mireille Maubru, Sandrine Decoster, Bernard Beauquey
Abstract: Microemulsion gels a) based on oil in water type, comprising an oil phase, substantially consisting of not easily volatile constituents, and an aqueous phase containing one or more O/W emulsifiers free from ethylene oxide and propylene oxide and possibly one or more additional O/W emulsifiers, an emulsifier content which is lower than 20 wt.
Type:
Grant
Filed:
June 18, 1999
Date of Patent:
October 22, 2002
Assignee:
Beiersdorf AG
Inventors:
Khiet Hien Diec, Wolfgang Meier, Jörg Schreiber
Abstract: Microbicidal and spermicidal devices, methods, and compositions containing sodium dodecyl sulfate or related anionic surfactants as active ingredients for the prevention and control of pregnancy and sexually transmitted disease, including conditions caused by non-enveloped viruses such as human papilloma virus.
Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth.
Abstract: Amphiphilic fluorinated block copolymers are disclosed which are useful for increasing the dispersability of particles, preferably drug particles, in a fluorine-containing propellant.
Type:
Grant
Filed:
May 26, 2000
Date of Patent:
September 17, 2002
Assignee:
Smithkline Beecham Corporation
Inventors:
Joseph M. Desimone, Terri Johnson Carson, John F. Miller, Sharon Wells
Abstract: Albuterol formulations packaged in an oxygen-permeable plastic container have a long shelf life at room temperature. The formulations consist essentially of albuterol or a pharmaceutically acceptable salt thereof, sodium chloride, and water, have a pH of about 4, and contain less than 0.08% by weight of albuterol aldehyde and less than 1 ppm dissolved oxygen.
Type:
Grant
Filed:
March 22, 2001
Date of Patent:
September 17, 2002
Assignee:
Sepracor Inc.
Inventors:
Robert J. Wherry, III, Stewart H. Mueller
Abstract: This invention relates to a medical aerosol formulation and more particularly, to a medicinal aerosol formulation containing a rosiglitazone maleate and a fluid carrier.
Type:
Grant
Filed:
October 31, 2000
Date of Patent:
September 10, 2002
Assignee:
Aeropharm Technology Incorporated
Inventors:
Anthony J. Cutie, Akwete L. Adjei, Frederick A. Sexton