Abstract: Isoflavonoids containing a carbon-carbon linked .beta.-D-glucose moiety at the C-8 position and isolated from the Chinese herbal plant Pueraria lobata are useful for treating alcohol dependence.
Type:
Grant
Filed:
April 23, 1996
Date of Patent:
July 21, 1998
Assignee:
Natural Pharmacia International, Inc.
Inventors:
Yue-Hu Pei, David Overstreet, Amir Hosein Rezvani, David Yue-Wei Lee
Abstract: Psychotic symptoms are treated by the administration of drugs which amplify the ability of natural stimulators of AMPA receptors to enhance the mediation of excitatory synaptic response. What is previously known about the activity and effectiveness of these drugs is unrelated to the etiology of psychotic symptoms. The invention finds particular utility in the treatment of schizophrenia.
Type:
Grant
Filed:
August 30, 1995
Date of Patent:
June 30, 1998
Assignees:
Gary A. Rogers, The Regents of the University of California
Inventors:
John Larson, Gary Lynch, Gary A. Rogers
Abstract: This invention provides a series of novel substituted propanamides which are useful in the a physiological condition which may be modulated by an increase in growth hormone. This invention also provides methods for the treatment of such physiological conditions which comprise administering a growth hormone secretagogue as described in the present invention in combination with growth hormone releasing hormone.
Type:
Grant
Filed:
August 20, 1996
Date of Patent:
June 30, 1998
Assignee:
Eli Lilly and Company
Inventors:
Philip Arthur Hipskind, Jeffrey Alan Dodge
Abstract: The invention provides the use of a cyclooxygenase inhibitor such as the non-steroidal anti-inflammatory agent aspirin in the manufacture of a medicament to enhance perfusion of blood through the mammalian, preferably human, uterus. The enhanced perfusion aids embryo implantation in natural or assisted methods of conception.
Type:
Grant
Filed:
June 23, 1995
Date of Patent:
June 2, 1998
Assignee:
Applied Research Systems ARS Holding N.V.
Abstract: An O/W type lipstick overcoat composition comprising (i) 2 to 80% by weight of a dimethyl polysiloxane, and/or a perfluoro polyether in an inner phase; and (ii) (a) water and (b) a silica powder and/or alumina powder in an outer phase or a W/O type lipstick overcoat composition (i) 40 to 70% by weight of a dimethyl polysiloxane in an outer phase and (ii) (a) water and (b) a silica powder and/or alumina powder in an inner phase.
Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or acyl; provided that only one of R.sup.1 or R.sup.2 is hydrogen are taught as useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.
Abstract: The anthelmintic efficacy in animals and humans of a benzimidazole such as fenbendazole, albendazole, oxfendazole or trichlabendazole is potentiated by use with piperonyl butoxide or other methylenedioxyphenyl synergist.
Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.
Type:
Grant
Filed:
October 24, 1995
Date of Patent:
April 21, 1998
Assignee:
Marshall University Research Corporation
Abstract: A composition is disclosed containing non-esterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.
Abstract: Methods for promoting animal growth comprising administering one or more substances selected from o-nitrophenol, p-nitrophenol, 5-nitroguaiacol and salts thereof as active ingredients.
Abstract: The present invention relates to novel pharmaceutical composition for skin diseases, in particular to novel pharmaceutical composition useful for treatment of skin diseases; e.g. burns, wounds, general operative wounds, pernio, decubitus, folliculitis, impetigo, intertrigo, radiation ulcer, acne vulgaris or infectious eczematous dermatitis comprising deproteinized dialysate of calf's blood with tissue regenerative activity and aminoglycoside antibiotic with bacterial infection inhibitory activity as active ingredients.
Type:
Grant
Filed:
July 25, 1996
Date of Patent:
March 24, 1998
Assignee:
Yungjin Pharmaceutical Co., Ltd.
Inventors:
Kae Jong Chung, Man Sik Chang, Jong Ok Chun, Jae Kwang Chun, Wahn Soo Choi, Sung Chul Kim
Abstract: The use of compound 1 and/or 2 of the formulae ##STR1## and of physiologically tolerable salts of compound 2 for the treatment of rejection reactions of the organ recipient to the transplanted organ is described.
Abstract: A protective cream composition contains 15 to 40 wt % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of a topical agent such as an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 to 8.0 wt. %, of an alkali metal silicate, and the balance water. Such a composition can be applied to the skin to protect health care workers and other from infection. The cream dries to form a topical barrier on the skin, and also contains an agent effective against, for instance, viruses such as human HIV. Once a medical operation is completed, the film formed from the dried cream can be washed off with soap and water. Other topical agents present in the composition include, for instance, suncreens, insect repellents and chemical repellents.
Abstract: This invention relates to a method for modifying metabolism in a vertebrate animal which entails the administration of pantethine or cysteamine at a predetermined time daily. The method is useful in the treatment of hyperglycemia, glucose intolerance, insulin resistance, and hyperinsulinemia.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
February 3, 1998
Assignees:
Ergo Science Incorporated, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Anthony H. Cincotta, Albert H. Meier, John M. Wilson
Abstract: The optically pure R-isomer of the adrenergic beta-2 agonist albuterol, substantially free of its corresponding S-isomer, has been found to potently inhibit premature uterine contractions in female subjects, suffering from said condition, while avoiding side effects associated with the corresponding S-isomer. A new method is disclosed utilizing the optically pure R(-)-isomer of albuterol for treating premature uterine contractions while minimizing the side effects associated with administration of racemic albuterol.
Abstract: The invention provides a method for treating a condition resulting from the cessation and withdrawal of nicotine comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno?2,3-b!?1,5!-benzodiazepine.
Abstract: Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging from 2000 to 7000, combined with suitable excipients and/or diluents.
Type:
Grant
Filed:
April 18, 1994
Date of Patent:
December 9, 1997
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco della Valle, Roberto Cerini, Gabriella Calderini