Patents Examined by M. S. Howard
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Patent number: 4988385Abstract: Compounds of the general formula ##STR1## in which R.sup.1 and R.sup.2 each independently represents an alkyl group, Z represents a nitrogen atom or a group CH unsubstituted or substituted by a substituent X, m is 0 or an integer from 1 to 4, the or each Y represents a halogen atom, n is 0 or an integer from 1 to 5, and the or each X represents a halogen atom or a group selected from alkyl, haloalkyl, cyanoalkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, cyano, nitro, alkylsulphonyl, alkylsulphinyl, and sulphonamido, have been found to have herbicidal activity.Type: GrantFiled: May 26, 1989Date of Patent: January 29, 1991Assignee: Shell Internationale Research Maatschappij B.V.Inventors: Terence Gilkerson, Robert W. Shaw
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Patent number: 4981993Abstract: The invention concerns new polyfunctional ethylenic monomers of the general formula (I): ##STR1## where R=cyano, substituted or unsubstituted acyl, substituted or unsubstituted alkoxycarbonyl or substituted or unsubstituted aryloxycarbonyl; R.sub.1 and R.sub.2 each represent --CHR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 may be identical or different and represent H or an alkyl, alkenyl or aralkyl group. R.sub.1 and R.sub.2 may, alternatively, together form a radical --CH.sub.2 --(CR.sub.5 R.sub.6).sub.n --CHR.sub.7 where n=0 or 1 and R.sub.5, R.sub.6 and R.sub.7 may be identical or different and represent H or CH.sub.3.Particular monomers are: 2-cyano-4,4-dimethoxy-3-hydroxy-1-butene; 2-cyano-4,4-dibutoxy-3-hydroxy-1-butene; 4,4-dibutoxy-2-ethoxycarbonyl-3-hydroxy-1-butene; 2-butoxycarbonyl-4,4-dibutoxy-3-hydroxy-1-butene; 4,4-dimethoxy-2-hydroxythoxycarbonyl-1-butene; 4,4-dimethoxy-2-dimethylaminoethoxycarbonyl -3-hydroxy-1-butene; and 4,4-dimethoxy-2-ethoxycarbonyl-3-hydroxy-1-butene.Type: GrantFiled: August 18, 1988Date of Patent: January 1, 1991Assignee: Societe Francaise HoechstInventors: Didier Wilhelm, Alain Blanc
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Patent number: 4981990Abstract: The invention relates to a process for the preparation of 4-phenylpyrrole derivatives of the formula I ##STR1## wherein R.sub.n, R.sub.1 and R.sub.2 are as defined in claim 1, which comprises reacting a phenacylamine of formula II ##STR2## with a compound of formula IIIT--CH.dbd.CH--R.sub.1 (III)to give an intermediate of formula IV ##STR3## and cyclizing said intermediate, in the presence of a base, to give the compound I.Important intermediates and novel final products are also described.Type: GrantFiled: December 22, 1988Date of Patent: January 1, 1991Assignee: Ciba-Geigy CorporationInventor: Pierre Martin
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Patent number: 4975433Abstract: A compound of the formula: ##STR1## wherein: R and R.sub.1 may be the same or different and are selected from the group consisting of H; cycloalkyl groups having up to 10 carbon atoms; or straight or branched chain alkyl, alkenyl or alkynyl of 1 to 10 carbon atoms;R.sub.2 and R.sub.3 together with the nitrogen atom to which they are bonded form a pyrrolidine, piperidine, N-methyl piperazine, piperazine or morpholine ring;or a non-toxic pharmaceutically acceptable salt, adduct, oxide or other derivative thereof; and pharmaceutical compositions adapted for topical administration to a human or non-human animal and methods of topically administering the compositions to humans and non-human animals.Type: GrantFiled: January 31, 1989Date of Patent: December 4, 1990Assignee: University of FloridaInventor: Kenneth B. Sloan
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Patent number: 4970309Abstract: This invention relates to a novel method of synthesizing di- and triarylmethane dye precursor compounds possessing a thiolactone ring-closing moiety, from the corresponding lactones.Type: GrantFiled: December 7, 1989Date of Patent: November 13, 1990Assignee: Polaroid CorporationInventor: Patrick F. King
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Patent number: 4968830Abstract: Halogen substituted aromatic compounds of the formula ##STR1## wherein Y is selected from the group CO.sub.2 H, COF, COCl, COBr, CF.sub.3, CN, NCO, or F, and X and X' are independently hydrogen or a halogen selected from the group F-, Cl- and Br-, at least one of X and X' being halogen; may be prepared by the liquid phase reaction of a brominating agent, at temperatures below about 190.degree. Celsius, with a correspondingly substituted cyclohexene or cyclohexadiene.Type: GrantFiled: September 11, 1989Date of Patent: November 6, 1990Assignee: Occidental Chemical CorporationInventor: David Y. Tang
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Patent number: 4968813Abstract: Certain new chemical compounds are derivatives of 4H-thiopyran-1,1-dioxides, and are useful as electron-transport agents in electrophotographic elements.Type: GrantFiled: December 22, 1989Date of Patent: November 6, 1990Assignee: Eastman Kodak CompanyInventors: Norman G. Rule, Teh-Ming Kung
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Patent number: 4963580Abstract: Position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzothiophenes and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.Type: GrantFiled: November 27, 1989Date of Patent: October 16, 1990Assignee: Merck & Co., Inc.Inventors: Robert A. Zambias, Milton L. Hammond
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Patent number: 4960904Abstract: Cyclic sulphates of formula: ##STR1## are prepared by oxidation of a cyclic sulphite of formula: ##STR2## with a hypohalite of an alkali or alkaline-earth metal and a catalytic quantity of a ruthernium derivative (RuO.sub.2, RuCl.sub.3). In formulae (I) and (II), R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are identical or different and each represents hydrogen, halogen, alkyl, alkoxy, aryl, aryloxy or alkoxycarbonyl.Type: GrantFiled: September 6, 1989Date of Patent: October 2, 1990Assignee: Rhone-Poulenc SanteInventors: Pierre Le Roy, Bernadette Mandard-Cazin
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Patent number: 4960768Abstract: Novel fungicidally active acyloxythiophene-carboxamides of the formula ##STR1## in which R.sup.1 represents alkyl, alkoxyalkyl, alkylthioalkyl, fluoroalkyl, cyanoalkyl, alkenyl, alkinyl or cycloalkyl,R.sup.2 represents alkyl or optionally substituted phenyl,R.sup.Type: GrantFiled: May 8, 1989Date of Patent: October 2, 1990Assignee: Bayer AktiengesellschaftInventors: Werner Daum, Gerd Hanssler
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Patent number: 4960758Abstract: The present invention relates to .beta.-D-phenylthioxyloside compounds selected from the group consisting of:(i) the .beta.-D-phenylthioxylosides of the formula: ##STR1## in which: R.sub.1 and R.sub.2, which can be identical or different, which represent a hydrogen atom or a trifluoromethy or cyano group,A represents CHOH or CO andY represents a hydrogen atom or an acyl group; and(ii) epimers thereof when A is CHOH.The said .beta.-D-phenylthioxyloside compounds are useful in therapy as antithrombotics.Type: GrantFiled: November 3, 1988Date of Patent: October 2, 1990Assignee: Fournier Innovation et SynergieInventors: Soth Samreth, Francois Bellamy, Jean Millet
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Patent number: 4959385Abstract: This invention relates to thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Ar represents optionally substituted phenyl, Y represents an ethylene or methylene radical or a valency bond, and n represents 0 or 1, bioprecursors thereof and pharmaceutically acceptable salts thereof which possess useful pharmacological properties, processes for their preparation and compositions containing them.Type: GrantFiled: January 19, 1989Date of Patent: September 25, 1990Assignee: May & Baker LimitedInventors: David C. Cook, Terance W. Hart, Iain M. McLay, Malcolm N. Palfreyman, Roger J. Walsh, Jean-Claude Aloup
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Patent number: 4958026Abstract: The disclosure relates to novel dopamine derivatives of general Formula I ##STR1## wherein A is a substituted phenyl residue of the structure ##STR2## wherein R.sup.1 and R.sup.2, being identical or different, mean hydrogen, C.sub.1-15 -alkyl and allyl,D is ##STR3## R.sub.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, CF.sub.3, NH.sub.2 E is ##STR4## X is OH, NH.sub.2, ##STR5## and NH--SO.sub.2 --CF.sub.3, if Y=OH, Y is OH, NH.sub.2, ##STR6## NH--SO.sub.2 --CF.sub.3 and NH--SO.sub.2 --CH.sub.3, if X=OH, but wherein X and Y do not simultaneously mean OH, with R.sup.3 being C.sub.1-4 -alkyl, andZ is H or OH, and, if Z means the hydroxy group, the residue A can also be present in the tautomeric basic form,and their acid addition salts, their preparation, and use as medicinal agents having antihypertensive activity.Type: GrantFiled: May 30, 1986Date of Patent: September 18, 1990Assignee: Schering AktiengesllschaftInventors: Klaus Schoellkopf, Rudolf Albrecht, Manfred Lehmann, Gertrud Schroeder
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Patent number: 4958021Abstract: Benzopyran derivatives of the formula ##STR1## where X is the radical ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and also the ring A have defined meanings are used in pressure- or heat-sensitive layers.Type: GrantFiled: July 19, 1988Date of Patent: September 18, 1990Assignee: BASF AktiengesellschaftInventors: Andreas Guentner, Udo Mayer, Andreas Oberlinner
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Patent number: 4946968Abstract: Alkali metal salts of 2-pyrrolidone-5-carboxylic acid (pyroglutamic acid) are prepared by heating the corresponding alkali metal salt of glutamic acid to a temperature between its melting point and 270.degree. C. until the water liberated by the intramolecular condensation (cyclocondensation) has been completely eliminated.Type: GrantFiled: October 17, 1988Date of Patent: August 7, 1990Assignee: Degussa AktiengesellschaftInventors: Hans-Peter Krimmer, Karlheinz Drauz, Hans Remmel
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Patent number: 4946860Abstract: Disclosed are novel benzothiopyranyl derivatives as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## their corresponding dihydroxy acids, and pharmaceutically acceptable salts thereof.Type: GrantFiled: November 3, 1989Date of Patent: August 7, 1990Assignee: Rorer Pharmaceutical CorporationInventors: Robert L. Morris, Jeffrey N. Barton
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Patent number: 4939280Abstract: 4-Oxaaldehydes of the formula ##STR1## are prepared by catalytic isomerization of 1,3-dioxanes by a process in which a 1,3-dioxane of the formula ##STR2## where R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are identical or different and are each hydrogen, a straight-chain or branched alkyl, alkenyl or alkynyl radical of not more than 18 carbon atoms, a cycloalkyl or cycloalkenyl radical of 5 to 8 carbon atoms, an aryl, alkylaryl, aralkyl or alkenylaryl radical of 5 to 16 carbon atoms or a heterocyclic radical, and furthermore R.sup.1 and R.sup.2 and/or R.sup.4 and R.sup.5 together with the carbon atom to which they are bonded may form a cycloalkane, a cycloalkene or a heterocyclic structure, and the stated radicals may furthermore carry substituents which are inert under the reaction conditions, and R.sup.3 is hydrogen or straight-chain or branched alkyl, is isomerized using a phosphate as a catalyst.Type: GrantFiled: April 29, 1988Date of Patent: July 3, 1990Assignee: BASF AktiengesellschaftInventors: Wolfgang Hoelderich, Franz Merger, Helmut Lermer
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Patent number: 4939136Abstract: The invention relates to new anellated indole derivatives of general formula 2, ##STR1## wherein p1 R.sub.0 is alkyl or alkoxy having 1-4 C-atoms, phenylalkoxy having 1-3 C-atoms in the alkoxy group, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or a group R.sub.7 S(O).sub.p, wherein R.sub.7 is alkyl having 1-4 C-atoms and p has the value 0, 1 or 2, or R.sub.0 is a group R.sub.8 R.sub.9 N, R.sub.8 R.sub.9 N--CO--CH.sub.2 -- or R.sub.8 R.sub.9 --N--CO wherein R.sub.8 and R.sub.9 are hydrogen or alkyl having 1-4 C-atoms or R.sub.8 R.sub.9 N forms a saturated 5- or 6-membered ring and n has the value 0, 1 or 2, Z together with the carbon atom and nitrogen atom to which Z is bound and the intermediate carbon atom, forms a heterocyclic group consisting of 5-8 ring atoms, in which, in addition to the nitrogen atom already present, a --CO--group or a second hetero atom from the group N, O, S, S-O or SO.sub.Type: GrantFiled: June 24, 1988Date of Patent: July 3, 1990Assignee: Duphar International Research B.V.Inventors: Hans H. Haeck, Derk Hamminga, Ineke Van Wijngaarden, Wouter Wouters
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Patent number: 4937253Abstract: This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.Type: GrantFiled: September 23, 1988Date of Patent: June 26, 1990Assignee: SmithKline Beecham CorporationInventors: John G. Gleason, Ralph F. Hall, John F. Newton, Kathleen A. Phipps, Joanne Smallheer
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Patent number: 4925658Abstract: Aromatic esters and thioesters have the formula ##STR1## wherein X represents oxygen or sulfur,R.sub.1 represents --CH.sub.2 OH, --CH(OH)--CH.sub.3, --COOR.sub.5 or ##STR2## R.sub.5 represents hydrogen, lower alkyl, lower alkenyl, monohydroxyalkyl or polyhydroxyalkyl,r' and r" represent hydrogen, lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar, or taken together form a heterocycle,R.sub.2 represents .alpha.,.alpha.'-disubstituted alkyl having 4-12 carbon atoms or mono- or polycyclic cycloalkyl having 5-12 carbon atoms whose carbon linking carbon is trisubstituted,R.sub.3 represents hydrogen, lower alkyl, or --Si(CH.sub.3).sub.2 R'.sub.3 wherein R'.sub.3 represents lower alkyl, andR.sub.4 represents hydrogen or lower alkyl, andthe salts of these aromatic esters and thioesters of formula (I) when R.sub.5 represents hydrogen.Type: GrantFiled: January 19, 1989Date of Patent: May 15, 1990Assignee: Centre International De Recherches dermatologiques (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon