Abstract: According to an example aspect of the present invention, there is provided method for measuring wound healing, comprising, measuring a wound impedance by a first tetrapolar arrangement of electrodes arranged on both sides of a wound, measuring a reference impedance by a second tetrapolar arrangement of electrodes arranged on one side of the wound, determining, by a controller, wound healing on the basis of the wound impedance and the reference impedance measured over a frequency range.

Abstract: An implantable medical device has a therapy module configured to generate a composite pacing pulse including a series of at least two individual pulses. The therapy module is configured to generate the composite pacing pulse by generating a first pulse of the at least two individual pulses by selectively coupling a first portion of a plurality of capacitors to an output signal line and generate a second pulse of the at least two individual pulses by selectively coupling a second portion of the plurality of capacitors to the output signal line.

Abstract: An implantable medical device comprises a sensing module configured to obtain electrical signals from one or more electrodes and a control module configured to process the electrical signals from the sensing module in accordance with a tachyarrhythmia detection algorithm to monitor for a tachyarrhythmia. The control module detects initiation of a pacing train delivered by a second implantable medical device, determines a type of the detected pacing train, and modifies the tachyarrhythmia detection algorithm based on the type of the detected pacing train.

Abstract: Apparatus and methods for imposing electric fields through a target region in a body of a patient are described. The apparatus includes a sensor array having a plurality of temperature sensors with a plurality of first temperature sensors of the sensor array connected to a first conductor, and a plurality of second temperature sensors connected to a second conductor. A circuit is configured to provide a known amount of electricity via the first conductor and the second conductor to a third temperature sensor, the third temperature sensor within the plurality of first temperature sensors, and within the plurality of second temperature sensors.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to treat mood disorders in a patient using a compact implantable neurostimulator and corresponding lead(s) that are shaped, sized and configured to be implanted beneath a patient's skin in the head or neck, and to stimulate one or more target cranial nerves. The one or more medical electrical leads comprising electrode(s) are positioned adjacent to, in contact with, or in operative positional relationship to, the one or more target cranial nerves of the patient. In some embodiments, electrical stimulation is provided to the one or more target cranial nerve(s) of the patient for periods of time ranging between 30 and 60 minutes, once or twice per day. In some embodiments, power is provided to the implantable neurostimulator transcutaneously by inductive, wireless, RF, acoustic, microwave, or other suitable non-invasive means.

Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of Collagen Type XVII Alpha 1 chain (COL17A1), a useful protein, by tissues. Also described are methods of COL17A1 in cells.

Abstract: A method is disclosed for controlling an eye surgical laser for the separation of a volume body with predefined interfaces from a human or animal cornea. The method includes controlling the laser by means of a control device such that it emits pulsed laser pulses in a predefined pattern into the cornea, wherein the interfaces of the volume body to be separated are defined by the predefined pattern and a surface of the cornea and the interfaces located in the cornea are generated by photodisruption. A treatment device is also disclosed that includes at least one eye surgical laser for the separation of a predefined corneal volume with predefined interfaces of a human or animal eye by photodisruption, and at least one control device for the laser or lasers, which is formed to execute the steps of the method.

Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes one or more physiological sensors configured to sense a physiological signal indicative of patient brain activity. The physiological signals may include an electroencephalography signal, a magnetoencephalography signal, or a brain-evoked potential. The system may extract from the brain activity signal one or more signal metrics indicative of strength or pattern of brain electromagnetic activity associated with pain, and generate a pain score using the one or more signal metrics. The pain score can be output to a patient or a process. The system may select an electrode configuration for pain-relief electrostimulation based on the pain score, and deliver a closed-loop pain therapy according to the selected electrode configuration.

Abstract: An implantable device and associated method for delivering multi-site pacing therapy is disclosed. The device comprises a set of electrodes including a first and second left ventricular electrodes spatially separated from one another and a right ventricular electrode, all coupled to an implantable pulse generator. The processing circuit coupled to the implantable pulse generator, the processing circuit configured to determine whether a prospective heart failure condition has occurred and if so to trigger the pulse generator to switch from a first pacing mode to a second pacing mode, the first pacing mode comprising delivering only a first pacing pulse to a left ventricle (LV) and thereafter delivering an RV pacing pulse to the right ventricular electrode within a single cardiac cycle and the second pacing mode comprising delivering first and a second pacing pulses to the LV and thereafter delivering an RV pacing pulse to the right ventricular electrode within a single cardiac cycle.

Abstract: A method for targeted drug delivery. The method includes preparing a drug composition with a surface electric charge, injecting the drug composition into a cancer patient's body, placing an electrically conductive element in a region next to a tumor location inside the cancer patient's body, and delivering the drug composition to the tumor location. Delivering the drug composition to the tumor location includes electrostatically trapping the drug composition within the tumor location by applying an electrostatic field with an opposite sign of electric charge to a sign of the surface electric charge of the drug composition to the electrically conductive element.

Abstract: A computing device includes a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations that include providing an alternating electrical signal to a patient through at least a pair of electrodes, and determining transthoracic impedance of the patient from a measurement associated with the applied alternating electrical signal. Operations also include identifying, from the transthoracic impedance, a sequence of resistance values for controlling the discharge of a charge storage device located external to the patient, and controlling the discharge of the charge storage device using the identified sequence of resistance values.

Abstract: A device for delivering low-level electromagnetic radiation to a patient includes a core portion including an upper surface and defining at least a portion of a base surface opposite the upper surface. The base surface is substantially planar and configured to rest on a substrate. The device also includes a cushion layer mounted on the upper surface and substantially defining a contact surface. The contact surface is opposite the base surface and contoured to support a curvature of a sub-occipital region and a lower neck region of the patient in a supine position. The device further includes a plurality of emitters coupled proximate to the contact surface and configured to emit low-level electromagnetic radiation transdermally to at least one of the sub-occipital region and the lower neck region.

Abstract: A planning device that generates control data for an ophthalmological laser therapy appliance with a laser device and a control unit, includes a first interface for supplying various data and a second interface for transferring the control data to the control unit of the ophthalmological laser therapy appliance, which is embodied to generate control data for a scanning pattern for the ophthalmological laser therapy appliance from the supplied data, by application of which scanning pattern a structure can be produced in the cornea, the limbus, and/or the sclera of a patient's eye. The planning device is embodied to generate from the supplied data, control data for the scanning pattern of this structure and/or a structure for receiving the shunt implant.

Abstract: Systems and techniques are disclosed to generate programming parameters and modifications during closed-loop adjustment of an implantable neurostimulation device treatment programming, through the identification and application of weights determined from user input indications and rankings of therapy objectives.

Abstract: The present invention relates to a computer-implemented method for electrocardiogram analysis, the method comprising the steps of receiving at least one ECG signal; analyzing the ECG signal to provide features and/or identify at least one episode and/or event, wherein an episode is a segment of the ECG signal defined by a starting time, a duration and a label obtained during the analysis of the ECG signal and an event is a strip of the ECG signal of predefined duration defined by a starting time and a label obtained during the analysis of the ECG signal; and displaying a multiple field display (1) which includes at least a main plot (42), being a global view of a graphic representation of the ECG signal in a first time window; a local view of a graphic representation of the ECG signal in a second time window (51), where the first time window comprises the second time window; an intermediate view of a graphic representation of the ECG signal in a third time window (52), wherein the third time window comprises

Abstract: Systems and related methods for supplying power to an implantable blood pump are provided. A system includes a base module and a plurality of energy storage devices. A first energy storage device is operatively coupled to the base module. A second energy storage device is operatively coupled to the first modular energy storage device. The energy storage devices are mechanically coupled in series, electrically coupled in parallel, and configured to provide redundant sources of power to drive an implantable blood pump.

Abstract: A method for electrophysiological assessment, including acquiring electrical signals from locations of a region of ablated tissue in a heart chamber, and deriving from the signals respective annotations, which are indicative of times within a heart cycle at which a conduction wave traversed the locations. The method includes identifying a first location, at a first distance from the region, where the electrical signals include a double-potential signal, having first and second annotations at different times within the heart cycle, and identifying, in proximity to the first location, a second location, at a second distance from the region, greater than the first distance, where the electrical signals have a third annotation. The method further includes selecting one of the first and second annotations that is closest to the third annotation as a valid annotation for the first location, and displaying the valid annotation on an electroanatomical map of the heart.

Abstract: A trial stimulation system includes a trial electrical stimulator. Additionally, systems for securing a disposable trial stimulator to the body of a patient are described, which may function to improve the durability of the system during the trial period and reduce the risk of damage or malfunction to the system due to lead/electrode dislocation and/or off-label uses like showering or bathing with the trial stimulator still secured to the body.

Abstract: Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

Abstract: Implantable medical devices (IMDs) described herein, and methods for use therewith described herein, reduce how often an IMD accepts a false message and/or reduce adverse effects of an IMD accepting a false message. Such IMDs can be leadless pacemakers (LPs), or implantable cardio defibrillators (ICDs), but are not limited thereto. Such embodiments can be used help multiple IMDs (e.g., multiple LPs) implanted within a same patient maintain synchronous operation, such as synchronous multi-chamber pacing.