Patents Examined by Margaret D. Seaman
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Patent number: 7405302Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.Type: GrantFiled: October 4, 2006Date of Patent: July 29, 2008Assignee: Amira Pharmaceuticals, Inc.Inventors: John H. Hutchinson, Petpiboon Peppi Prasit, Mark Moran, Jillian F. Evans, Jasmine Eleanor Zunic, Nicholas Simon Stock
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Patent number: 7388096Abstract: The instant invention provides crystalline forms of 1-(3-chlorophenyl)-7-oxo-6-[4-(2-oxo-1 (2H)pyridinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.Type: GrantFiled: September 26, 2005Date of Patent: June 17, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Margaret M. Gleeson, Gary McGeorge, Bang-Chi Chen, Huiping Zhang, Mary F. Malley, John D. DiMarco, Denette K. Murphy, Xiaotian Yin, Steven R. Fabian, Jasmine M. Gupta
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Patent number: 7384955Abstract: Compounds of formula I or pharmaceutically acceptable salts thereof Formula (I) wherein Ar, R1, R2, R3, Ra, Rb and X are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared.Type: GrantFiled: March 26, 2004Date of Patent: June 10, 2008Assignee: AstraZeneca ABInventors: Zhongyong Wei, Regis Dolaine, Christopher Walpole, Hua Yang
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Patent number: 7381743Abstract: The present invention relates to new macrocycles of the general formula (I) as well as their use for the treatment of cancer diseasesType: GrantFiled: November 26, 2004Date of Patent: June 3, 2008Assignee: Leibniz-Institut Fuer Pflanzenbiochemie (IPB)Inventors: Ludger A. Wessjohann, Uwe Eichelberger, Thao Tran Thi Phuong
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Patent number: 7381733Abstract: The present invention relates to the use of tropane derivatives having dopamine reuptake inhibitor activity for the treatment of diseases associated with reduced blood flow to the brain or with instances of a temporary break in blood supply to the brain, such as ischemic diseases.Type: GrantFiled: November 28, 2002Date of Patent: June 3, 2008Assignee: Neurosearch A/SInventors: Jørgen Scheel-Krüger, Lars Christian B. Rønn
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Patent number: 7375113Abstract: The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula R1 represent H, an optionally substituted alkyl group, analkenyl group, etc.; R2 represent H, a halogen atom or an alkyl group; R3 and R4 represent H, OH, a halogen atom, an optionally substituted alkyl group, etc.; Y represents CH or N; Q represents alkylene, alkenylene, etc.; ring A represents an aryl group or a heteroaryl group; G represents a group represented by the following general formula (G-1) or (G-2) (in which E1 represents H, F or OH; and E2 represents H, F, a methyl group, etc.Type: GrantFiled: March 3, 2005Date of Patent: May 20, 2008Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuhiko Fushimi, Hirotaka Teranishi, Kazuo Shimizu, Shigeru Yonekubo, Fumiaki Ito, Masayuki Isaji
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Patent number: 7375114Abstract: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: April 6, 2005Date of Patent: May 20, 2008Assignee: Theravance, Inc.Inventors: Daniel Marquess, Paul R. Fatheree, S. Derek Turner, Daniel D. Long, Seok-Ki Choi, Adam A. Goldblum, Daniel Genov
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Patent number: 7375112Abstract: The present invention provides a method of administering vitamin B6 related compounds for treatment of hypertriglyceridemia. Vitamin B6 related compounds include pyridoxal, pyridoxal-5?-phosphate, pyridoxamine, a 3-acylated analogue of pyridoxal, a 3-acylated analogue of pyridoxal-4,5-aminal, and mixtures thereof. Embodiments of the present invention also comprise co-administering a lipid lowering agent, such as a nicotinic acid, a fibrate, a HMG CoA reductase inhibitor, a cholesteryl ester transfer protein inhibitor, and combinations thereof.Type: GrantFiled: January 5, 2006Date of Patent: May 20, 2008Assignee: Medicure International Inc.Inventors: Albert D. Friesen, Marjorie Zettler
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Patent number: 7371864Abstract: The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.Type: GrantFiled: December 14, 2005Date of Patent: May 13, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Michael J. Orwat, Mary F. Malley, Roxana Schlam, Steven R. Fabian, Bing-Shiou Yang, Victor W. Rosso
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Patent number: 7371863Abstract: The present invention relates to a new method of preparing gaboxadol (THIP), which is useful for treating sleep disorders. In particular a method of preparing THIP comprising reacting a compound of formula (8b) or a salt thereof with an acid, typically a mineral acid, to obtain THIP as an acid addition salt.Type: GrantFiled: September 1, 2004Date of Patent: May 13, 2008Assignee: H. Lundbeck A/SInventors: Hans Petersen, Michael Bech Sommer, Robert Dancer
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Patent number: 7368460Abstract: The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or more fluorine atoms, or C3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and R2 is phenyl optionally substituted by one or more fluorine atoms, to pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds.Type: GrantFiled: October 3, 2003Date of Patent: May 6, 2008Assignee: Pfizer, Inc.Inventors: Manoussos Perros, David Anthony Price, Blanda Luzia Christa Stammen, Anthony Wood
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Patent number: 7365095Abstract: Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.Type: GrantFiled: April 21, 2006Date of Patent: April 29, 2008Assignee: WyethInventors: Gavin David Heffernan, Gary Paul Stack, Jonathan Laird Gross, Dahui Zhou, Hong Gao
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Patent number: 7365080Abstract: The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) interactions with effector cell adhesion molecules (ECAM) are useful for treating diseases and disorders mediated by GAG-ECAMs interactions, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.Type: GrantFiled: February 5, 2004Date of Patent: April 29, 2008Assignee: Rimonyx Pharmaceuticals Ltd.Inventors: Paul Gregor, Nicholas Harris, Juraj Koppel, Regina Zhuk
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Patent number: 7365215Abstract: The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (2): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, a noble metal catalyst and a metal oxide, and a synthetic intermediate thereof and a process for preparing the same.Type: GrantFiled: July 14, 2004Date of Patent: April 29, 2008Assignee: Ube Industries, Ltd.Inventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Keiji Iwamoto, Takashi Harada, Shinobu Suzuki
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Patent number: 7365066Abstract: Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.Type: GrantFiled: September 16, 2003Date of Patent: April 29, 2008Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Rosanne Bonjouklian, Junkai Liao, William Thomas McMillen, Brandon Lee Parkhurst, Jason Scott Sawyer, Jonathan Michael Yingling, Jeremy Schulenburg York
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Patent number: 7361667Abstract: The present invention describes a method for the treatment of attention deficit hyperactivity disorder (ADHD), conduct disorder, alcohol addiction, tobacco addiction, nicotine addiction, parkinsonism including Parkinson's disease, female and male orgasmic disorders, female and male sexual arousal disorders, hypoactive sexual desire disorder, and disorders characterized by anxiety and/or depression. In this method, a therapeutically effective, nontoxic dose of a 4?,4?-substituted 3?-(diphenylmethoxy) tropane analog or a pharmaceutically acceptable salt thereof is administered to the patient in need of such treatment.Type: GrantFiled: January 7, 2004Date of Patent: April 22, 2008Assignee: P2D, Inc.Inventor: Frank P. Zemlan
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Patent number: 7361766Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, A, B, b, n, W, X, Y and Z are described herein.Type: GrantFiled: January 12, 2006Date of Patent: April 22, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Chongqing Sun, William R. Ewing, Yanting Huang, Yeheng Zhu
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Patent number: 7358249Abstract: A heterocyclic compound of the formula (I): wherein B1 is —C(R2)? or —N?; R1? is H, etc.; one of R1 and R2 is -Z1-Z2-Z3-R5 wherein Z1 and Z3 are independently single bond, optionally substituted alkylene, etc.; Z2 is single bond, optionally substituted alkylene, etc.; R5 is optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of R1 and R2 is H; -A1- is —C(—Y)?C(—RA)—C(—R3)?C(—R4)—, etc. wherein Y is OH, etc.; RA is —COR7 wherein R7 is OH, etc.; one of R3 and R4 is carboxy, etc., and the other of R1 and R2 is H, etc, a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.Type: GrantFiled: August 11, 2003Date of Patent: April 15, 2008Assignee: Shionogi & Co., Ltd.Inventors: Hitoshi Murai, Takeshi Endo, Noriyuki Kurose, Teruhiko Taishi, Hiroshi Yoshida
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Patent number: 7358364Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.Type: GrantFiled: April 14, 2004Date of Patent: April 15, 2008Assignee: The Institute for Pharmaceutical Discovery LLCInventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
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Patent number: 7354929Abstract: Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described hereinType: GrantFiled: October 4, 2006Date of Patent: April 8, 2008Assignee: Pfizer Inc.Inventors: Philip A. Carpino, David A. Griffith