Abstract: A composition comprising sucralfate and one or more anti-acid epigastralgic relieving agents in a weight ratio of between 0.5:1.0 to 1.3 sucralfate to anti-acid epigastralgic relieving agent and a method of using the composition for relieving symptoms of gastrointestinal mucosal irritation in mammals. The composition may be either in liquid or solid dose form having a combined composition weight percentage of 10-30% per 5 milliliter volume of liquid or 40-85% per solid unit dose form.

Abstract: Antifungal composition comprising synergistic combination of fungal cell wall degrading enzyme selected from the , group consisting of chitinolytic enzymes, glucanolytic enzymes and cellulases and non-enzymatic fungicides selected from the group consisting of sterol synthesis inhibiting fungicides (e.g., flusilazole and miconazole) and thiol group inactivating fungicides which are not specific to fungal cell membranes (e.g., captan) are applied in an antifungal effective amount to fungus to be inhibited or to a locus to be protected from said fungus.

Abstract: A novel microorganism, Coniothyrium fuckelii ATCC 74227, and a process of using the microorganism for the production of lovastatin comprising fermenting Coniothyrium fuckelii ATCC 74227 or a lovastatin-producing mutant thereof in a nutrient medium containing assimilable sources of carbon, nitrogen, and inorganic salts under aerobic fermentation conditions.

Abstract: The invention relates to a process for producing a cyclosporin, especially cyclosporin A, by cultivating the strain (LEA3) of the novel Tolypocladium species aerobically at a temperature of 20.degree.-30 .degree. C. in a nutrient medium containing carbon sources, nitrogen sources and mineral salts, and, if desired, isolating and purifying the resulting cyclosporin.

Abstract: New glycopeptide antibiotic A83850, comprising A83850A, and A83850B, is produced by Amycolatopsis albus strain NRRL 18532. A83850A and A83850B can be reduced to give new biologically active denatures. The A83850 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.

Abstract: The present invention provides a substantially pure culture of Pseudomonas sp. strain PED having the ATCC designation 49794. Processes for making R-configured alcohols and for transferring a hydride ion from an R-configured alcohol to the pro-R face of NAD using PED alcohol dehydrogenase isolated and purified from Pseudomonas sp. strain PED are also provided.

Abstract: Substituted (1.alpha., 2.beta., 3.alpha. or .beta.,4.alpha.,5.alpha. or .beta.)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentylamines are inhibitors of alphamannosidase and alpha-fucosidase and are useful immunostimulants, antiviral and antimetastatic agents.

Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.

Abstract: A method for retarding the growth of wood-degrading fungi by treating the wood with an effective amount of viable, nonsporulating Streptomyces rimosus SC-36 NRRL 21063.

Abstract: A process for preparing a stabilized aloe vera gel which includes separating the clear gel from the whole leaf of the aloe vera plant, by grinding and mixing the whole leaf with a cellulose dissolving compound. Clear aloe vera gel is obtained through a series of filtration steps. A selected quantity of an oxygen scavenging enzyme, such as glucose oxidase is added to the mixture to remove oxygen from within the gel and inhibit the growth of aerobic bacteria therein, and ultra-violet light is used to sterilize the gel without the addition of heat thereto. The material can be passed through a final organic filter to remove any remaining bacteria.

Abstract: A microbiological process for the production of 5-hydroxypyrazinecarboxylic acid and/or its salts with microorganisms of the strain Agrobacterium sp. DSM 6336 or descendants thereof or mutants thereof, utilizing 3-cyanopyridine.

Abstract: Normally anchorage-dependent insect cell lines are adapted to replicate under suspension conditions by addition of heparin to the culture medium and selection for resulting suspension-tolerant cells.

Abstract: Pyrroquinoline quinone-dependent glycerol dehydrogenase is provided which requires no surfactant for its solubilization and stabilization. The glycerol dehydrogenase has the following properties:(a) catalyzing the following reaction: glycerol+electron acceptor.dbd.glyceraldehyde+reduced electron acceptor,(b) optimum pH: pH 8-9,(c) pH stability: stable at pH 7-11,(d) optimum temperature: 20.degree.-25.degree. C.,(e) thermal stability: stable at a temperature of 30.degree. C. or less for 10 minutes at a pH of 7.0,(f) molecular weight: 70,000 by gel filtration and SDS polyacrylamide gel electrophoresis,(g) bound to pyrroloquinoline quinone as a prosthetic group,(h) soluble and stable without the need of an ionic or non-ionic surfactant.

Abstract: The invention relates to a process for the selective production of polyunsaturated fatty acids from a culture of microalgae of Porphyrium cruentum. The process comprises growing a biomass by culturing the microalgae in a photobioreactor under optimum culturing conditions, removing a portion of the resulting biomass, and subjecting the removed portion to a temperature decrease. The result is the selective increase in the quantity of a given polyunsaturated fatty acid within the microalgae biomass.

Abstract: Antifungal composition comprising synergistic combination of fungal cell wall degrading enzyme selected from the group consisting of chitinolytic enzymes, glucanolytic enzymes and cellulases and non-enzymatic fungicides selected from the group consisting of sterol synthesis inhibiting fungicides (e.g., flusilazole and miconazole) and thiol group inactivating fungicides which are not specific to fungal cell membranes (e.g., captan) are applied in an antifungal effective amount to fungus to be inhibited or to a locus to be protected from said fungus.