Abstract: Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Abstract: An electric field cancer treatment apparatus using a rotating alternating current (AC) electric field according to an embodiment of the present disclosure includes a plurality of electrode pairs configured to transmit AC electric fields to a target area in a body, a plurality of AC electric field generators respectively connected to the plurality of electrode pairs and configured to generate AC electric fields to be applied to the plurality of electrode pairs, and a controller configured to control generation of AC electric fields by the plurality of AC electric field generators.

Abstract: A method to provide skin care treatment is provided. The method includes receiving, by an electrical stimulator apparatus, programmable instructions from an external device for a skin care treatment. The electrical stimulator apparatus delivers an electric current to an area of skin through a plurality of electrodes. The electric current is controlled based on the skin care treatment. The external device presents guidance corresponding with the skin care treatment. The guidance is configured to aid a user in operating the electrical stimulator apparatus.

Abstract: Systems and methods which provide radial exterior weld terminal configurations for medical device leads are described. A radial exterior weld terminal may comprise an annular conductive structure having a radial exterior weld interface feature, wherein a medical device lead may comprise one or more radial exterior weld terminals. A radial exterior weld interface feature may be disposed at an end of the annular conductive structure and may configure the annular conductive structure to accept a non-axially directed portion of a conductive wire for interfacing a conductor with a weld location on an outer surface of the radial exterior weld terminal. The radial exterior weld interface feature may comprise a truncated aperture configured for the non-axially directed portion of conductive wire to traverse from the inner space to the outer surface. The truncated aperture may comprise a dimple member depressed into the interior space of the annular conductive structure.

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Abstract: A method of treating a patient and an external programmer for use with a neurostimulator. Electrical stimulation energy is conveyed into tissue of the patient via a specified combination of a plurality of electrodes, thereby creating one or more clinical effects. An influence of the specified electrode combination on the clinical effect(s) is determined. An anatomical region of interest is displayed in registration with a graphical representation of the plurality of electrodes. The displayed anatomical region of interest is modified based on the determined influence of the specified electrode combination on the clinical effect(s).

Abstract: A device for enhancing mandibular bone growth can include left and right head modules, a headband linking the left and right head modules and supporting the head modules, at least one transmitter circuit fixed to respective left and right head modules, left and right electrodes configured for receiving the transmitted electromagnetic field, and left and right transmitter antenna rods fixed to the left and right electrodes for receiving signals from the transmitter. The transmitter circuit can include a power supply, a driver, and at least one transmitter capable of transmitting an electromagnetic field for transmission to the patient's mandible.

Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.

Abstract: The invention relates to a method and system for treating an area with radio frequency radiation with a resonant frequency and modulation function calibrated to destroy harmful pathogens, such as bacteria, viruses or other germs. According to the present invention, transmitters are used to neutralize harmful pathogens within a space, and may be used with corresponding receivers are used to verify the functional performance of the transmitters, and to create a data stream so that human occupants of the spaces so being treated can be assured that the areas they occupy have been so treated.

Abstract: A catheter pump system is disclosed. The catheter pump system can include a shaft assembly and an impeller coupled with a distal portion of the shaft assembly. A motor assembly can impart rotation on the impeller through the shaft assembly, the motor assembly comprising a motor which rotates the shaft assembly. The catheter pump system can include a fluid pathway which conveys fluid proximally during operation of the catheter pump system. A seal can be disposed between the motor assembly and the impeller. The seal can be configured to impede or prevent the fluid from the fluid pathway from entering the motor assembly at least about an outer periphery of the shaft assembly. The seal can comprise an opening through which a portion of the shaft assembly extends.

Abstract: The present application relates to stacked piezoelectric composites comprising piezoelectric structures. Suitably, the composites are useful as tissue-stimulating implants, including spinal fusion implants. The present application also relates to methods of making stacked piezoelectric composites.

Abstract: An electrode assembly includes a substrate, a plurality of electrodes, and a wiring assembly. The substrate includes an elongate body extending from a first end to a second end in a first direction and a plurality of electrode connection structures connected with the elongate body. Each electrode connection structure defines a first coupling end, a second coupling end, and a first opening positioned between the first coupling end and the second coupling end. The electrodes are positioned within the plurality of electrode connection structures. A portion of each electrode extends through the first opening of the respective electrode connection structure. The wiring assembly extends along the substrate and forms an electrical connection with each of the plurality of the electrodes.

Abstract: The present disclosure provides a method for a neuromodulation treatment of a low urinary tract dysfunction. The neuromodulation method comprises attaching at least one active electrode to at least one leg of the patient in the back of the knee area in an expected location of a peroneal nerve of the at least one leg. Attaching a grounding electrode to the patient's body. Generating electrical pulses by a pulse generator connected to the at least one active electrode and the grounding electrode. Controlling via a control unit a flow of the generated electrical pulses to the at least one active electrode and stimulating by the at least one active electrode the peroneal nerve of the at least one leg of the patient.

Abstract: A method of treating tissue of a patient uses a device including a mother case, a belt, at least one treatment unit and at least two applicators. The treatment method may include attaching first and second applicators to the belt at a working distance to the patient's surface, and providing different treatment energy to the first applicator and the second applicator. A treatment pattern is created by the applicators providing the different treatment energies. The hardware pattern or positions of the applicators on the belt may be changed before and/or during the treatment. The hardware pattern may be based on selected treatment effect and body part.

Abstract: An apparatus includes a power adapter having a housing and a circuit at least partially disposed in the housing. The housing is configured to be coupled to an implantable device for disposition in a body. The circuit is configured to be electrically connected to a power circuit of the implantable device when the housing is coupled to the implantable electrical conductor. When the housing is coupled to the implantable electrical conductor and implanted in a body, the circuit is configured to (1) receive, transcutaneously from a power supply, a first energy, (2) convert the first energy to a second energy, and (3) transfer, to the implantable device, the second energy such that the second energy powers the implantable device.

Abstract: A leadless neurostimulation device including a header unit having at least one primary electrode having a contact surface that defines an external surface on a side of the device, an outer housing that forms a side of the header unit opposite of the contact surface of the primary electrode, and a dielectric mount that receives at least a portion of the primary electrode and at least partially surrounds the primary electrode, the dielectric mount being configured to electrically insulate the primary electrode from the outer housing, the dielectric mount being received and fixed within a recessed portion of the outer housing, and a housing having a secondary electrode positioned on the same side of the leadless neurostimulation device as the primary electrode, the primary electrode and the secondary electrode being configured to transmit an electrical stimulation signal therebetween to provide electrical stimulation therapy to a tibial nerve of a patient.

Abstract: Electrical probe assemblies, such as nerve probe assemblies, are disclosed herein. In one example implementation, a nerve probe assembly may include an electrical probe including an electrode disposed on or about an end thereof for electrically stimulating tissue or recording stimulated tissue activity, an axial length of the electrical probe including a shapeable part; a rigid sheathing adapted to cover and thereby inhibit a portion of the shapeable part of the axial length of the electrical probe from being shaped, the portion of the shapeable part covered by the rigid sheathing being adjustable; and a handle and an adjustment structure affixed to respective ones of the electrical probe and the rigid sheathing, the handle and the adjustment structure adapted to cooperate to enable adjustment of the portion of the shapeable part of the axial length of the electrical probe covered by the rigid sheathing.

Abstract: An implantable cardiac defibrillator (ICD) system includes an ICD implanted subcutaneously in a patient, a defibrillation lead having a proximal portion coupled to the ICD and a distal portion having a defibrillation electrode configured to deliver a defibrillation or cardioversion shock to a heart of the patient, and a pacing lead that includes a distal portion having one or more electrodes and a proximal portion coupled to the ICD. The distal portion of the pacing lead is implanted at least partially along a posterior side of a sternum of the patient within the anterior mediastinum. The ICD is configured to provide pacing pulses to the heart of the patient via the pacing lead and provide defibrillation shocks to the patient via the defibrillation lead. As such, the implantable cardiac system provides pacing from the substernal space for an extravascular ICD system.

Abstract: Some implementations provide an implantable wirelessly powered device for implantation in a patient's body, the device including: electrode arrays configured to apply at least one electrical pulse to an excitable tissue, each electrode array including at least one electrode; two or more connector contacts, each integrally wired to a particular electrode array, each configured to drive the at least one electrode of the particular electrode array integrally wired thereto with the at least one electrical pulse and to set a polarity for each of the at least one electrode of the particular electrode array integrally wired thereto; a first antenna configured to: receive, from a second antenna and through electrical radiative coupling, an input signal containing electrical energy as well as polarity assignment information, the second antenna located outside the patient's body; and one or more circuits electrically connected to the first antenna and the connector contacts.

Abstract: Methods of improving addiction in a patient in need thereof are provided. Methods include exposing the patient to drug related cues and measuring the patient's craving levels or physiological levels during or after cue exposure to determine the patient's status or condition. Such a determination can indicate whether the patient is at risk of engaging in the addictive activity and can guide therapeutic intervention.