Abstract: The present invention relates to compositions comprising one or more compounds and/or extracts which induce, promote and/or improve production/release/delivery/excretion of hyaluronic acid from and/or in the cornea, and methods of using the compositions to treat the eye.
Abstract: The invention relates to vaccine compositions for treating and/or preventing infections by a bacterium of the Chlamydiaceae family, said compositions comprising bacteria of the Chlamydiaceae family, which have been previously treated by at least one peptidoglycan inhibitor, or extracts of said treated bacteria.
Type:
Grant
Filed:
December 15, 2021
Date of Patent:
January 9, 2024
Inventors:
Philippe Verbeke, Colette Kanellopoulos
Abstract: The compositions and methods are described for generating an immune response to a Plasmodium antigen. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to malaria by expressing the Plasmodium antigen in the subject to which the MVA vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat malaria.
Type:
Grant
Filed:
April 21, 2022
Date of Patent:
January 2, 2024
Assignee:
Geovax, Inc.
Inventors:
Farshad Guirakhoo, Arban Domi, Nathanael Paul McCurley
Abstract: The invention provides methods of modulating an immune system in a vertebrate host for the therapeutic or prophylactic treatment of infection by a first microbial pathogen in a target tissue, comprising administration at an administration site of an effective amount of an antigenic formulation comprising antigenic determinants specific for a second heterologous microbial pathogen.
Type:
Grant
Filed:
January 21, 2021
Date of Patent:
November 21, 2023
Assignee:
Qu Biologics Inc.
Inventors:
Harold David Gunn, Salim Dhanji, David W. Mullins
Abstract: A strain of Lactobacillus gasseri KBL697 and the use thereof are described. The strain of Lactobacillus gasseri KBL697 (Accession No. KCTC 13520BP) attenuates allergic reactions of cells, significantly improves symptoms of atopic dermatitis, and exhibits anti-inflammatory and anti-fungal effects and a therapeutic effect for intestinal diseases such as irritable bowel syndrome and colitis. Thus, the single strain alone can achieve all the purposes of alleviating allergic diseases and inflammatory diseases and improving intestinal health, thereby finding advantageous applications as a probiotic substance. In addition, the strain, based on the anti-fungal activity thereof, can be advantageously utilized in a skin external preparation against various skin diseases caused by fungi, and in a cosmetic composition and a functional patch for alleviating sensitive skin.
Type:
Grant
Filed:
February 16, 2022
Date of Patent:
November 21, 2023
Assignee:
KoBioLabs, Inc.
Inventors:
Woo Ri Ko, June Chul Lee, Hyo In Park, Tae Wook Nam, Gwang Pyo Ko, Woon Ki Kim, Dae Hee Han, In Su Kim, Jin Woo Lee, Hye Jin Kim
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Type:
Grant
Filed:
March 26, 2021
Date of Patent:
October 17, 2023
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: Disclosed herein are the genetically modified Pseudomonas with improved tolerance to hydroxycinnamic acids.
Type:
Grant
Filed:
February 24, 2021
Date of Patent:
October 10, 2023
Assignees:
Alliance for Sustainable Energy, LLC, UT-Battelle, LLC
Inventors:
Gregg Tyler Beckham, Christopher W. Johnson, Allison Jean Zimont Werner, Davinia Salvachúa Rodríguez, Daniel A. Jacobson, Erica Teixeira Prates, Elsayed Tharwat Tolba Mohamed, Adam Michael Feist
Abstract: Through the use of a universal anti-tick antigens, multiple tick-borne diseases that occur over a significant area can be targeted for eradication. The novel reservoir targeted anti-tick treatment is designed to reduce tick numbers and thereby blocking transmission of tick-borne diseases.
Type:
Grant
Filed:
January 10, 2022
Date of Patent:
October 3, 2023
Assignee:
US Biologic, Inc
Inventors:
Jolieke Gerdy van Oosterwijk, Douglas Steven Zatechka, Jr., Luciana Meirelles Richer
Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
Type:
Grant
Filed:
March 22, 2021
Date of Patent:
September 26, 2023
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: The invention provides streptolysin O containing a polypeptide comprising an amino acid sequence having deletion of a polypeptide extending from a lysine residue at position 2 of SEQ ID NO: 1 to any of an alanine residue at position 31, a glutamate residue at position 32, a serine residue at position 33, and an asparagine residue at position 34, and also having deletion of any of an isoleucine residue at position 465 to an alanine residue at position 472 of SEQ ID NO: 1 and all of the subsequent amino acid residues, as well as variants thereof and related DNA, vectors, transformants, and methods of use thereof.
Abstract: A method for quantitatively assessing muscle contraction and corresponding kits are described. The method can include assessing muscle contraction of a facial muscle by applying an external electrical stimulus to facial skin sufficient to contract a facial muscle, and measuring the contractile activity of the contracted facial muscle. The method can be used to determine the ability of a treatment material to reduce contraction of the facial muscle.
Type:
Grant
Filed:
February 7, 2019
Date of Patent:
September 12, 2023
Assignee:
MARY KAY INC.
Inventors:
Shoná Burkes-Henderson, Geetha Kalahasti, David Gan
Abstract: A microorganism identification method according to the present invention includes a step of subjecting a sample containing microorganisms to mass spectrometry to obtain a mass spectrum, a step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum, and an identification step of identifying which bacteria of serovar of Salmonella genus bacteria the microorganisms contained in the sample contain, based on the mass-to-charge ratio m/z, in which at least one of two types of ribosomal proteins S8 and Peptidylpropyl isomerase is used as the marker protein.
Abstract: Provided are compositions, devices and systems, methods for assessing, treating and/or preventing an intraocular disease or disorder in a subject, wherein the etiology of the intraocular disease or disorder comprises infection of a microorganism in the intraocular space or cavity of the subject. Provided are compositions, devices and systems, and methods for assessing, treating and/or preventing age-related macular degeneration (AMD) in a subject, e.g., a human patient.
Abstract: The present invention provides specific peptide biomarkers and sets of peptide biomarkers for use in methods of detecting or identifying bacterial biomarkers in a sample, wherein said bacterial biomarkers can be used to detect Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, and/or Moraxella catarrhalis in a sample. Kits and diagnostic methods are also provided.
Abstract: The present invention is directed to methods for determining active DPP3 in a bodily fluid sample, an assay or kit for determining active DPP3 in a bodily fluid sample, a method for diagnosing a disease or condition in a subject accompanied by or related to necrotic processes and methods of treating or preventing said disease.
Abstract: Provided are use of an Echovirus 25 (ECHO25) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the ECHO25 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, in treatment of a tumor in a subject, and in the manufacture of a medicament for treatment a tumor in a subject.
Type:
Grant
Filed:
August 15, 2018
Date of Patent:
July 25, 2023
Assignees:
XIAMEN UNIVERSITY, YANG SHENG TANG COMPANY, LTD.
Inventors:
Tong Cheng, Wei Wang, Junkai Wan, Longfa Xu, Xiangzhong Ye, Jun Zhang, Ningshao Xia
Abstract: The present invention provides a method of controlling growth of unwanted microorganisms by limiting their access to manganese. More specifically, the present invention provides a method of inhibiting or delaying growth of yeast and mold by reducing the manganese concentration in a product which is preferably a food product. The invention also provides manganese scavengers and uses thereof to inhibit or delay fungal growth.
Type:
Grant
Filed:
April 17, 2019
Date of Patent:
July 25, 2023
Assignee:
Chr. Hansen A/S
Inventors:
Solvej Siedler, Martin Holm Rau, Stina Dissing Aunsbjerg Nielsen