Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.
Type:
Grant
Filed:
August 29, 2018
Date of Patent:
August 22, 2023
Assignees:
MUSC Foundation for Research Development, Lukogene Therapeutics Incorporated
Inventors:
Nathan G. Dolloff, Reeder M. Robinson, Allen B. Reitz, Haiyan Bian
Abstract: Provided are crystals of 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate, compositions comprising the same, and methods of making and using such crystals.
Type:
Grant
Filed:
August 27, 2021
Date of Patent:
August 15, 2023
Assignee:
Aeromics, Inc.
Inventors:
Paul Robert McGuirk, Robert Zamboni, Melanie Bevill, Stephan Parent
Abstract: The present application provides hydrogel microcapsules, particularly, canonized hydrogel microcapsules having improved substantivity. This application further relates to the use of hydrogel microcapsules for delivering encapsulated actives in a wide range of industries and applications including: agrochemicals, pharmaceuticals, cosmetics industry, personal care products, laundering detergents, homecare & cleaning products, dish washing detergents, oral care, dental care, textiles, paper, mining, oil industry, water treatment, adhesives, coatings, plastics, sealants, construction, paints, inks and dyes onto different substrate surfaces such as skin, hair, textiles.
Type:
Grant
Filed:
December 1, 2011
Date of Patent:
August 8, 2023
Assignee:
ISP Investments LLC
Inventors:
Kishor Kumar Mistry, Abdul Wahab Hussain, Petra Helga Beck, David Vaughan Palmer, Benjamin Roger Sales, Andrew Mint
Abstract: Presented herein is a coupling method for the preparation of 1,2-di(thiophen-2-yl)ethane-1,2-diol compounds, including (E)-1,2-di(thiophen-2-yl)ethene-1,2-diol, via a Cu(II) catalyst.
Type:
Grant
Filed:
December 30, 2021
Date of Patent:
August 8, 2023
Assignee:
QATAR UNIVERSITY
Inventors:
Ismail K. Warad, Amjad M. Shraim, Anas Al-Ali, Kifah S M Salih, Abdelkader Zarrouk, Yousef Hijji
Abstract: The present disclosure relates to the use of cannabidiol (CBD) for the reduction of total convulsive seizure frequency in the treatment of “treatment-resistant epilepsy” (TRE). In particular, the disclosure relates to the use of CBD of treating TRE when the TRE is Dravet syndrome; myoclonic absence seizures or febrile infection related epilepsy syndrome (FIRES). The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).
Type:
Grant
Filed:
September 10, 2021
Date of Patent:
July 18, 2023
Assignee:
GW Research Limited
Inventors:
Geoffrey Guy, Stephen Wright, Orrin Devinsky
Abstract: The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
Type:
Grant
Filed:
February 23, 2021
Date of Patent:
July 11, 2023
Assignee:
Gilead Sciences, Inc.
Inventors:
Lan Jiang, David W. Lin, Michael L. Mitchell, Ezra Roberts, Gregg M. Schwarzwalder
Abstract: A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis (2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.
Type:
Grant
Filed:
May 24, 2021
Date of Patent:
June 20, 2023
Assignee:
Warsaw Orthopedic, Inc.
Inventors:
Roger E. Harrington, Jerbrena C. Jacobs, Robert Doyle
Abstract: The present disclosure is directed to novel crystalline forms of ozanimod and ozanimod hydrochloride, as well as preparation method thereof. Said crystalline forms of ozanimod and ozanimod hydrochloride can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, melting point, stability, dissolution, bioavailability and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.
Abstract: A colloidal dispersion of particles of silica having a particle size of from 3 nm to 100 nm, to which ions of one or more metals are adsorbed, selected from metals having atomic numbers 21-31, 39-46, 48-50, 57-82, and 89-93, and a method for preparing the dispersion. The dispersion may be used in various fields of use of metals.
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Type:
Grant
Filed:
November 4, 2020
Date of Patent:
June 13, 2023
Assignee:
NOVARTIS AG
Inventors:
Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth
Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
June 13, 2023
Assignees:
The Board of Trustees of the University of Illinois, The Regents of the University of California
Inventors:
John A. Katzenellenbogen, Seema K. Tiwari-Woodruff, Sung Hoon Kim, Benita Katzenellenbogen
Abstract: Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.
Type:
Grant
Filed:
July 20, 2018
Date of Patent:
May 30, 2023
Assignees:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: A porous particle, wherein the porous particle has a mass median aerodynamic diameter and a volume average particle diameter that satisfy expression: y?2x, where x denotes the mass median aerodynamic diameter and y denotes the volume average particle diameter, and the porous particle has a relative span factor (R.S.F) that satisfies expression: 0<(R.S.F)?1.5.
Type:
Grant
Filed:
June 23, 2020
Date of Patent:
May 23, 2023
Assignee:
Ricoh Company, Ltd.
Inventors:
Naoki Shiraishi, Tatsuru Moritani, Yuichi Sato
Abstract: Methods are provided for targeting cancer cells that over-express voltage-gated sodium channels (VGSCs or “sodium channels”) and causing osmotic lysis of these cancer cells by initially inhibiting the sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase or “sodium pump”), and then stimulating the VGSCs by pulsed magnetic field gradients to cause sodium and water to enter the cancer cells.
Type:
Grant
Filed:
July 12, 2018
Date of Patent:
May 23, 2023
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: In an embodiment, the present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type II diabetes mellitus.
Type:
Grant
Filed:
June 19, 2020
Date of Patent:
May 23, 2023
Assignee:
Eli Lilly and Company
Inventors:
David Andrew Coates, Todd Fields, Joseph Daniel Ho, Fucheng Qu
Abstract: The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof
Type:
Grant
Filed:
December 9, 2020
Date of Patent:
May 16, 2023
Assignee:
Actelion Pharmaceuticals Ltd
Inventors:
Charles Tokunbo Adesuyi, Bruce Hamilton Lithgow, Olivier Lambert, Lovelace Holman
Abstract: The present invention relates to the field of compounds, and in particular to a probucol derivative, a preparation method therefor and use thereof, the probucol derivative having a structure represented by general formula I. The probucol derivative provided in the present invention can be used for the prevention and treatment of vascular diseases including diabetes, cardio-cerebrovascular diseases or complications thereof, and can be effectively used for reducing blood glucose, reducing blood lipid, reducing cholesterol, reducing body weight, reducing triglyceride, anti-inflammatory, and anti-oxidation, etc., having broad prospective applications.
Abstract: A method by which an intermediate product of an azole derivative can be produced at a lower cost and in a higher yield than those of known production methods is realized. A method of producing a compound of General Formula (III) includes: producing the compound of General Formula (III) by allowing a cyanide compound to act on a ketone derivative of General Formula (II); and washing the compound of General Formula (III) produced in the producing the compound of General Formula (III) with an alkaline aqueous solution.
Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.
Type:
Grant
Filed:
October 6, 2021
Date of Patent:
May 2, 2023
Assignee:
Universiteit Antwerpen
Inventors:
Koen Augustyns, Jurgen Joossens, Pieter Van Der Veken, Paul Cos, Cedric Joossen, Benedicte Yvonne De Winter, Hannah Ceuleers, Hanne Van Spaendonk