Patents Examined by Maury Audet
  • Low molecular polypeptide for preventing and treating inflammation and use thereof
    Patent number: 10501511
    Abstract: Disclosed are a low molecular polypeptide for preventing and treating inflammation, a preparation method and the use thereof and a pharmaceutical composition containing the polypeptide, wherein the polypeptide can penetrate the eye tissue barrier, can maintain a high concentration in neutral tears, aqueous humour and vitreous humour, and can be used to treat inflammation.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: December 10, 2019
    Assignee: SHANGHAI FIRST PEOPLE'S HOSPITAL
    Inventors: Xun Xu, Lili Wang, Yi Xu
  • Mutated immunoglobulin-binding polypeptides
    Patent number: 10501557
    Abstract: An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:22, SEQ ID NO 51 or SEQ ID NO 52 wherein at least the asparagine or serine residue at the position corresponding to position 11 in SEQ ID NO:4-7 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: December 10, 2019
    Assignee: GE HEALTHCARE BIOPROCESS R&D AB
    Inventors: Gustav Rodrigo, Tomas Bjorkman, Mats Ander
  • Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
    Patent number: 10494403
    Abstract: A cyclopeptide is disclosed, which is represented by the following formula (I) or (I?): wherein R1 and G? are defined in the specification. In addition, a pharmaceutical or cosmetic composition comprising the same and a method for preparing the same are also disclosed.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: December 3, 2019
    Assignee: CIPHORE BIOMED TECHNOLOGY LIMITED COMPANY
    Inventor: Po-Ruay Chen
  • Templates for controlling synthesis of nanoparticles into discrete assemblies
    Patent number: 10479817
    Abstract: An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: November 19, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Nathaniel L. Rosi, Chun-Long Chen
  • Retinylamine derivitives for treatment of ocular disorders
    Patent number: 10471118
    Abstract: A pharmaceutical composition includes a retinylamine derivative having the following formula (I): where R1 is an amino acid residue, a dipeptide or a tripeptide that is linked to the retinylamine by an amide bond.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: November 12, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Krzysztof Palczewski, Zheng-Rong Lu
  • Cosmetic compositions
    Patent number: 10463585
    Abstract: A cosmetic composition is provided, the composition comprising a safe and effective amount of a skin care active with A log P less than ?2.0, a safe and effective amount of a fatty alcohol; and a safe and effective amount of a glyceryl ester. The combination of fatty alcohol and glyceryl esters surprisingly enhances penetration of skin care actives with low A log P values into skin.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: November 5, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Kunal Virendra Gujraty, Shikhar Gupta, Yan Yan, Naohisa Yoshimi
  • Antimicrobial peptides, their variants and uses
    Patent number: 10457709
    Abstract: The present invention relates to novel antimicrobial peptide and variants thereof. The invention further relates to method of killing or inhibiting growth of microbes and use of the peptide here disclosed as a medicament, feed additive, preservative or surfactant.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: October 29, 2019
    Assignee: Chain Antimicrobials Oy
    Inventors: Tejesvi Mysore Vishakante Gowda, Anna Maria Pirttilä
  • Antimicrobial peptides, their variants and uses
    Patent number: 10457710
    Abstract: The present invention relates to novel antimicrobial peptide and variants thereof. The invention further relates to method of killing or inhibiting growth of microbes and use of the peptide here disclosed as a medicament, feed additive, preservative or surfactant.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: October 29, 2019
    Assignee: Chain Antimicrobials Oy
    Inventors: Tejesvi Mysore Vishakante Gowda, Anna Maria Pirttilä
  • Charged nutritive proteins and methods
    Patent number: 10450350
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 22, 2019
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Methods for treating cancer
    Patent number: 10441663
    Abstract: The present invention relates to a method of treating cancer in a subject.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: October 15, 2019
    Assignee: BICYCLERD LIMITED
    Inventors: Gavin Bennett, Daniel Paul Teufel
  • Dermaseptin-type and piscidin-type antimicrobial peptides
    Patent number: 10428126
    Abstract: Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptides that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPS change selectivity from broad spectrum antimicrobial activity to AMPS with gram-negative selectivity.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: October 1, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Ziqing Jiang, Robert S. Hodges, Lajos Gera, Colin T. Mant
  • Antimicrobial protein
    Patent number: 10421792
    Abstract: The inventors provide a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof for use in a method of treatment of the human or animal body by therapy or prophylaxis, such as for use in a method of treating or preventing an infection in or on a subject by a microorganism. Also provided is the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to kill, or inhibit the growth of, a microorganism that is pathogenic to a human or an animal at a site that is not on or in the human or animal body.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: September 24, 2019
    Assignee: CONSUMO EM VERDE BIO TECHNOLOGIA DAS PLANTAS, S.A.
    Inventors: Alexandra Manuela Lourenço Carreira, Ricardo Manuel De Seixas Boavida Ferreira, Sara Alexandra Valadas Da Silva Monteiro
  • Method for separation of rare earth ion
    Patent number: 10400310
    Abstract: A method for identifying and separating a rare earth ion. The method includes bringing one or more rare earth ions into contact with a mineralization agent capable of mineralizing the rare earth ions, wherein the one or more rare earth ions are separated as rare earth minerals, based on a mineralization tendency of the mineralization agent with respect to a rare earth ion series.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 3, 2019
    Assignee: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Takaaki Hatanaka, Takao Tani, Nobuhiro Ishida
  • Compositions and methods for treating eye infections and disease
    Patent number: 10393755
    Abstract: The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: August 27, 2019
    Assignee: University of Virginia Patent Foundation
    Inventor: Gordon W. Laurie
  • Compositions and methods for treating alopecia
    Patent number: 10363240
    Abstract: The present invention is directed to a composition for treating alopecia containing minoxidil, cyclosporine A and a compound that binds FK506 binding protein 4 suitable for administration to humans. The present invention is further directed to treating alopecia in humans by administering a composition of the invention.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 30, 2019
    Assignee: DAVID WEINSTEIN CONSULTING, INC.
    Inventor: David Weinstein
  • Derivatives obtained from hyaluronic acid and carnosine
    Patent number: 10364299
    Abstract: The present invention relates to a derivative of carnosine (?-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 30, 2019
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, FIDIA FARMACEUTICI S.P.A.
    Inventors: Sebastiano Sciuto, Valentina Greco, Enrico Rizzarelli, Francesco Bellia, Valeria Lanza, Susanna Vaccaro, Luciano Messina
  • Single dose administration of factor VIIa
    Patent number: 10350276
    Abstract: The present invention provides methods for preventing and/or treating bleeding episodes by administering a single dose of a Factor VIIa equivalent. Preferably, the single dose comprises between about 150 and about 500 ug/kg Factor VIIa equivalent.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: July 16, 2019
    Assignee: Novo Nordisk HealthCare AG
    Inventor: Ulla Hedner
  • Compositions and methods for treating eye infections and disease
    Patent number: 10302658
    Abstract: The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but no normal tears.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: May 28, 2019
    Assignee: University of Virginia Patent Foundation
    Inventor: Gordon W. Laurie
  • Peptidomimetic macrocycles
    Patent number: 10300109
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an ?,?-disubstituted amino acid, or may comprise a crosslinker linking the ?-positions of at least two amino acids or at least one of said two amino acids may be an ?,?-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: May 28, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jia-Wen Han, Tomi K. Sawyer, Justin Noehre, Noriyuki Kawahata
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
    Patent number: 10300108
    Abstract: It is an object of the present invention to provide methods and compositions for protection of subjects from acute kidney injury by treating the subject with compounds that modulate the cell cycle. Modulating the cell cycle can comprise inducing G0/G1 cell cycle arrest, and/or inducing cell cycle progression. As demonstrated below, even a single administration of a compound which induces G0/G1 cell cycle arrest can protect subjects from AKI, and may be used prophylactically in advance of, or as a treatment following, various treatments or conditions that are known to be injurious to the kidney, followed optionally by release of the arrest. Once AKI is established, cell cycle progression can be induced to increase replacement of lost and damaged cells.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: May 28, 2019
    Assignees: Astute Medical, Inc., University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Paul McPherson, John A. Kellum