Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: The syringe dispenser includes a syringe and a plunger. The plunger includes a first shaft member including a piston and second shaft member configured to be fitted in a tubular portion of the first shaft member. The first shaft member includes an elastic piece, the elastic piece being provided with a slide projection configured to slide on an inner surface of the syringe and a lock projection configured to be locked against the syringe. The second shaft member includes a pressing shaft configured to be fitted in the tubular portion. The pressing shaft is provided in a front end thereof with an end surface configured to press a free end of the elastic piece. In response to pressing from the end surface, the lock projection is locked against the rear end of the syringe, and in response to the pressing being released, the locking of the lock projection is released.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple penetrators advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, nerve sensing, nerve stimulation, or ablation by application of energy. The catheter can include a proximal handle for the advancement of guide tubes and penetrators.

Abstract: An adjustable dosage limiting device is includes an elongated connecting member that has a plunger receiving head at a first end for capturing a plunger flange of a plunger of a syringe. A slidable member having a barrel loop is movable along the elongated connecting member. The slidable member slides up/down the elongated connecting member until, at a preset dosage, a locking mechanism is engaged to lock the slidable member, and hence the barrel loop, in place on the elongated member. Once locked in place, the adjustable dosage limiting device limits a dosage provided by the syringe based upon a distance between the plunger receiving head and the barrel loop as set by the locking mechanism.

Abstract: The invention relates to an injection system or a needle assembly in which a needle cannula secured to an injection device is shielded by a axially movable needle shield. Should the needle cannula be exposed to a force above a predetermined value e.g. if a user drops the injection device onto a hard surface, a locking mechanism will automatically lock and block further movement of the axially movable needle shield and thus render the injection device unusable.

Abstract: A drug delivery device includes an outer body receiving a cartridge with a needle, a needle cap adapted to be coupled to the outer body and to cover the needle and a control mechanism for activating the drug delivery device. The control mechanism includes a control element received within the outer body and axially and/or rotationally movable relative to the outer body between an initial position, a first activating position, and a second activating position. The control element is coupled to the needle cap and to the cartridge, the needle cap is retained on the outer body when the control element is in the initial position, the needle cap is released from the outer body and the needle is covered by the outer body when the control element is in the first activating position, and the needle is exposed when the control element is in the second activating position.

Abstract: Adapters for a connector assembly for percutaneous tubing are provided. A male adapter (FIG. 22a, 1000) includes a connector fitting (1002) proximate a first end, the connector fitting configured to join to a connector for a tubing system or device, and a male connector (656) proximate a second end. The male connector includes a plug end with a fluid lumen defined therethrough, the plug end having a circumferential groove defined therein to receive a locking extension of a female connector sized to be received within the circumferential groove of the plug end to allow the female connector to rotate relative to and maintain axial engagement with the male connector when the locking extension is received within the groove. An adapter having a female connector (FIG. 24, 1300) is also provided.

Abstract: A guiding catheter has a proximal portion constructed of a tubular braid and a shape-retentive distal portion including a superelastic hypotube cut to define particular mating, support, shape-retentive and flexibility characteristics. A tubular liner extends through both of the tubular braid and the hypotube. The hypotube is joined to the braid using a mechanical interlock that has high torque transfer from the braid to the hypotube. A short portion of high stiffness polymer tube is provided at a joint between the braid and the hypotube. A polymeric outer jacket is provided over the proximal and distal portions, including the polymer tube. The jacket is heat set over the hypotube to remove residual stress.

Abstract: A dosage limiting device is includes an elongated connecting member that has a plunger receiving head at a first end for capturing a plunger flange of a plunger of a syringe. The plunger receiving head has a back flange connected to the elongated connecting member and a forward slotted flange connected to the elongated connecting member, the forward slotted flange is separated from the back flange by a space sufficient to accept the plunger flange and a flat section of the plunger fitting in a slot of the forward slotted flange. A barrel loop is at a distal second end of the elongated connecting member so that the dosage limiting device limits a dosage provided by the syringe based upon a distance between the plunger receiving head and the barrel loop as the barrel loop abuts a barrel flange of the syringe, thereby limiting extraction of the plunger.

Abstract: The invention relates to a balloon catheter featuring—at least on portions of the outward-turned surface of the dilatable area—hair-like extensions, with the average diameter D, the average length L, and the average center-to-center distance P of the hair-like extensions to each other being selected such that a drug on the balloon surface covered with hair-like extensions can essentially be secured by means of capillary forces.

Abstract: A multi-port connector such as a closed intravenous (IV) access device with a y-port needle-free connector may be provided. The multi-port connector may include a main housing with a longitudinal axis, a needle free connector disposed along the longitudinal axis, and a y-port extending from a sidewall of the main housing at an angle that is non-parallel with the longitudinal axis. The needle-free connector may include a compressible sealing member that, when compressed opens a first fluid pathway from a first port, through a chamber within the housing, and to an output port. The y-port may be fluidly coupled to the chamber and the output port.

Abstract: The present invention relates to a piston for a cartridge to be filled with a medicament, the piston comprising: a first piston member (12) comprising a first material and forming a distal end face (22) of the piston, a second piston member (14) comprising a second material of lower compressibility compared to the first material, wherein the second piston member (14) is arranged in a cupped receptacle (16) of the first piston member (12) and provides a thrust receiving surface (25) at a proximal end (24) of the piston.

Abstract: Connector assembly (FIG. 4a) includes a shell (210), a connector body (230), and a plug (250). The shell (210) has a sidewall (212) defining an interior, a first shell end having a first opening (214) defined therein, and a second shell end having a second opening (216) defined therein, each of the first (214) and second openings (216) in communication with the interior to receive percutaneous tubing therethrough, the shell (210) further having an engagement portion. The connector body (230) has a first body end (234) and a second body end (236) with a tube lumen defined therethrough, the first body end (234) having a connector tip (237), the connector body (230) having an engaging portion to engage the engagement portion of the shell (210). The plug (250) has a first plug end and a second plug end with a fluid lumen defined therethrough, the first plug end having a plug tip (257) extending therefrom.

Abstract: The purpose of the present invention is to provide a micro-needle unit and an injection device capable of being readily connected to a liquid supply source and capable of performing an effective injection via a simple configuration. The micro-needle unit is provided with a plurality of micro-needles disposed on the puncturing side and provided with a flow channel, and drug solution supply needles disposed on the side opposite from the puncturing side in a number less than that of the micro-needles and provided with a flow channel in communication with the aforementioned flow channel, the micro-needle unit thereby being capable of being readily connected to a liquid supply source and capable of performing an effective injection via a simple configuration.

Abstract: A medical valve transitions between an open mode that permits fluid flow, and a closed mode that prevents fluid flow. To that end, the medical valve has a housing with an inlet and an outlet, a rigid member movably mounted within the housing, and a resilient member with a sealing portion. The housing also has at least one relief zone that is in fluid communication with the outlet when the valve is in the closed mode. The rigid member may have a proximal end, a distal end, and a flow channel. The relief zone may be radially outward from the sealing portion. The sealing portion may seal the valve and prevent fluid from passing through the valve when in the closed mode.

Abstract: An enteral adapter coupling for connecting non-ENFit threaded enteral equipment with ISO 80369-3 compliant and compatible enteral equipment. The adapter coupling includes a first end substantially corresponding to an ISO 80369-3 coupling format, a second end substantially conforming to a threaded enteral feeding coupling format, and an internal lumen extending through the coupling allowing fluid communication between the first end and the second end.

Abstract: A catheter insertion device that allows for single-handed insertion of the catheter within the vasculature of the patient is disclosed. The catheter insertion device includes a handle, a needle cannula partially within the handle, a guidewire partially within the handle and the needle cannula, and a first actuator connected to the handle and the guidewire. The guidewire is movable relative to the handle in a distal direction away from the handle, and in a proximal direction towards the handle. A catheter assembly is removably coupled to the handle and is configured to slide on the needle cannula. A catheter hub may be connected to a proximal end of the catheter, and a catheter advancer base may be releasably connected to the catheter hub. The catheter insertion device may also include a needle support pivotally connected to the handle for supporting the needle cannula on a cantilever portion thereof.

Abstract: The invention relates to a safety device, for avoiding stab wounds, for a syringe with a syringe body and with a puncturing means arranged at the distal end of the syringe body, said safety device comprising a sleeve element which extends along an axial direction (X) and at least partially encloses the puncturing means and the syringe body, wherein the sleeve element comprises, at its distal end, a contact portion which at least partially contacts the skin of a patient during use of the syringe and which delimits an opening surface. The safety device is characterized in that the opening surface has at least in part a sub-area that encloses an angle ? with the axial direction (X), wherein the angle ? is in a range of between 10° and 80°.

Abstract: In an embodiment, a medicament delivery system is provided. The medicament delivery system includes a container for storing a medicament prior to use, the container having a first end and a second end, an injection member in fluid communication with the container, an actuation mechanism associated with the container and configured to deliver the medicament from the container through the injection member when the actuation mechanism is activated. The medicament delivery system further includes at least one detection element associated with the system, wherein in a first mode of operation of the system, medicament is delivered through the injection member and in a second mode of operation of the system, medicament is not delivered through the injection member, and the mode of operation is dependent on an output from the at least one detection element.

Abstract: Disclosed are devices, systems, and methods for providing access to a patient. The patient access device comprises a proximal end, a distal end and a lumen therethrough. The patient access device further comprises a hollow shaft, an input port and a liquid supply port. At least a portion of the lumen passes through the shaft. The input port is coupled to the lumen, and the lumen and the input port are constructed and arranged to receive an elongate probe. The liquid supply port is in fluid communication with the lumen. The patient access is constructed and arranged to reduce gas from exiting the distal end while a portion of the elongate probe is positioned in the patient access device.