Abstract: A method and catalyst system for producing aromatic carbonates from aromatic hydroxy compounds is disclosed. In one embodiment, the method includes the step of contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system having an effective amount of a nickel source as the primary catalyst component in the absence of a Group VIII B metal source. In various alternative embodiments, the carbonylation catalyst system can include at least one inorganic co-catalyst, as well as a halide composition and/or a base.
Type:
Grant
Filed:
March 1, 2000
Date of Patent:
February 6, 2001
Assignee:
General Electric Company
Inventors:
Ben Purushotam Patel, Grigorii Lev Soloveichik, Donald Wayne Whisenhunt, Jr., Kirill Vladimirovich Shalyaev
Abstract: The invention concerns a process for preparing salts of organic acids of phosphorus. The organic acid is reacted with aluminum hydroxide in the presence of a polar solvent selected from acetic acid, propionic acid, methanol, ethanol, n-propanol, isopropanol, butanol, acetone, methyl ethyl ketone, tetrahydrofuran, dioxane, and acetonitrile.
Abstract: Hydroxyaromatic compounds such as phenol are carbonylated with oxygen and carbon monoxide in the presence of a catalyst system comprising a Group VIII metal having an atomic number of at least 44, preferably palladium; an alkali metal or alkaline earth metal halide, preferably sodium bromide; at least one carboxylic acid amide such as N-methylpyrrolidone or dimethylacetamide; and a cocatalyst which is a compound of one or more metals including copper, titanium, zinc, lead, cerium and manganese.
Type:
Grant
Filed:
August 27, 1999
Date of Patent:
January 30, 2001
Assignee:
General Electric Company
Inventors:
Bruce Fletcher Johnson, Grigorii Lev Soloveichik, Eric James Pressman, Kirill Vladimirovich Shalyaev
Abstract: A method and catalyst system for producing aromatic carbonates from aromatic hydroxy compounds. In one embodiment, the method includes the step of contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system having an effective amount of a manganese source in the absence of a Group VIII B metal source. In various alternative embodiments, the carbonylation catalyst system can include at least one inorganic co-catalyst, as well as a halide composition and/or a base.
Type:
Grant
Filed:
February 22, 2000
Date of Patent:
January 16, 2001
Assignee:
General Electric Company
Inventors:
Ben Purushotam Patel, Grigorii Lev Soloveichik, Donald Wayne Whisenhunt, Jr., Kirill Vladimirovich Shalyaev
Abstract: A method and catalyst system for producing aromatic carbonates from aromatic hydroxy compounds. In one embodiment, the method includes the step of contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system having an effective amount of a cobalt source in the absence of a Group VIII B metal source. In various alternative embodiments, the carbonylation catalyst system can include at least one inorganic co-catalyst, as well as a halide composition and/or a base.
Type:
Grant
Filed:
February 22, 2000
Date of Patent:
January 16, 2001
Assignee:
General Electric Company
Inventors:
Ben Purushotam Patel, Grigorii Lev Soloveichik, Donald Wayne Whisenhunt, Jr., Kirill Vladimirovich Shalyaev
Abstract: The present invention provides a simple and inexpensive method for producing &agr;-hydroxy-&bgr;-aminocarboxylic acids and their esters.
An ester of an N-protected &agr;-amino acid ester is converted into a &bgr;-ketosulfoxide, which is then processed with an acid to give an &agr;-ketohemimercaptal. Next, this is acylated and then processed with a base to obtain an N-protected &agr;-acyloxy-&bgr;-amino-thioester, which is then saponified to obtain an intended compound. According to the method of the present invention, it is possible to produce &agr;-hydroxy-&bgr;-aminocarboxylic acid derivatives, which are intermediates in producing various HIV protease inhibitors, renin inhibitors and carcinostatics, from a-amino acids. The method comprises reduced reaction steps, the selectivity in the method to give the intended product is high, and the yield of the product obtained is high.
Abstract: A process for separation between dialkyl carbonate and alkyl carbamate which comprises adding an aromatic hydroxy compound to a liquid comprising alkyl carbamate having an alkyl group having 3 to 6 carbon atoms and dialkyl carbonate having alkyl group having 3 to 6 carbon atoms to obtain a mixed liquid, and distilling the mixed liquid thus obtained in a distillation column to obtain a mixture comprising the dialkyl carbonate and the aromatic hydroxy compound from a top section of the distillation column and a liquid comprising the alkyl carbamate from a bottom section of the distillation column.
Abstract: A method is provided for co-producing dialkyl carbonate and alkanediol by reacting alkylene carbonate with alkanol in the presence of a Group 5 or Group 6 metal oxide catalyst.
Type:
Grant
Filed:
February 22, 2000
Date of Patent:
December 26, 2000
Assignee:
Mobil Oil Corporation
Inventors:
Clarence D. Chang, Larry E. Hoglen, Zhaozhong Jiang, Rene B. LaPierre
Abstract: A catalyst used for preparing thiochloroformates by reacting thiols with phosgene is a cyclic urea or cyclic thiourea which may be in the form of a salt obtainable by reaction with a hydrohalic acid or phosgene.
Type:
Grant
Filed:
February 17, 2000
Date of Patent:
December 19, 2000
Assignee:
BASF Aktiengesellschaft
Inventors:
Hans-Jurgen Weyer, Armin Stamm, Theodor Weber, Jochem Henkelmann
Abstract: A method is provided for co-producing dialkyl carbonate and alkanediol by reacting alkylene carbonate with alkanol in the presence of a complex salt catalyst having a formula A.sub.x (M.sub.y O.sub.z), wherein A is an alkali metal or alkaline earth metal, M is a Group 5 or Group 6 transition metal, O is oxygen, x is 1 or 2, y is 1 or 2, and z is an integer from 3 to 6.
Type:
Grant
Filed:
December 14, 1999
Date of Patent:
December 19, 2000
Assignee:
Mobil Oil Corporation
Inventors:
Clarence D. Chang, Larry E. Hoglen, Zhaozhong Jiang, Rene B. LaPierre
Abstract: A process for the production of a hydrofluoroalkane is disclosed which comprises contacting a halofluorocarbon or hydrohalofluorocarbon with hydrogen at elevated temperature in the presence of a hydrogenation catalyst which comprises palladium and an alkali metal carried on a support.
Type:
Grant
Filed:
July 10, 1998
Date of Patent:
December 12, 2000
Assignee:
Imperial Chemical Industries PLC
Inventors:
John David Scott, Gary Goodyear, John Charles McCarthy
Abstract: S-Alkylisothiouronium salts with phosphorus-containing acids are described. The compounds are used in processes of treating acute hypotension, which may result, for example, from shock or hemorrhage, and in processes for treating hyperoxic conditions, for example, oxygen poisoning.
Type:
Grant
Filed:
June 9, 1999
Date of Patent:
December 12, 2000
Assignee:
Meditor Pharmaceuticals Ltd.
Inventors:
Lev Mizrakh, Valentin Znamensky, Evgeni Arzamastsev, Lev Shagalov, Valeri Kovtun, Vladimir Jashounsky, Marina Kochetkova, Galina Bondareva, Olga Terekhova, Victor Gikavy, Victor Darchuk
Abstract: A method and catalyst system for economically producing aromatic carbonates from aromatic hydroxy compounds. In one embodiment, the present invention provides a method of carbonylating aromatic hydroxy compounds by contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system that includes a catalytic amount of an inorganic co-catalyst containing ytterbium. In various alternative embodiments, the carbonylation catalyst system can include an effective amount of a palladium source and an effective amount of a halide composition. Further alternative embodiments can include catalytic amounts of various inorganic co-catalyst combinations.
Type:
Grant
Filed:
April 29, 1999
Date of Patent:
December 12, 2000
Assignee:
General Electric Company
Inventors:
James Lawrence Spivack, Donald Wayne Whisenhunt, Jr., James Norman Cawse, Grigorii Lev Soloveichik
Abstract: The invention relates to a process for the preparation of aromatic oligocarbonates from dihydroxy compounds, CO and O.sub.2 in the presence of a platinum metal catalyst, a cocatalyst, a quaternary salt and a base, which is carried out in an inert organic solvent which, under the reaction conditions, forms an azeotrope with water, and this azeotrope is removed from the reaction mixture.
Abstract: A method and catalyst system for economically producing aromatic carbonates from aromatic hydroxy compounds. In one embodiment, the present invention provides a method of carbonylating aromatic hydroxy compounds by contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system that includes a catalytic amount of an inorganic co-catalyst containing copper. In various alternative embodiments, the carbonylation catalyst system can include an effective amount of a palladium source and an effective amount of a halide composition. Further alternative embodiments can include catalytic amounts of various inorganic co-catalyst combinations.
Type:
Grant
Filed:
April 29, 1999
Date of Patent:
December 12, 2000
Assignee:
General Electric Company
Inventors:
James Lawrence Spivack, Donald Wayne Whisenhunt, Jr., James Norman Cawse, Bruce Fletcher Johnson, Marsha Mottel Grade, Grigorii Lev Soloveichik, John Yaw Ofori, Eric James Pressman
Abstract: An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxamide, an intermediate for an HIV protease inhibitor.
Type:
Grant
Filed:
August 4, 1999
Date of Patent:
December 5, 2000
Assignee:
Merck & Co., Inc.
Inventors:
Kai Rossen, Philip J. Pye, Ralph P. Volante, Paul J. Reider
Abstract: A 2-phenoxyaniline derivative represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, an amino group or an NHCOR.sup.3 group, R.sup.2 is a halogen atom, an amino group, a cyano group, a C.sub.1-6 alkyl group, a C.sub.1-3 perfluoroalkyl group, an NHCOR.sup.3 group, a CH.sub.2 OR.sup.4 group, an OCH.sub.2 R.sup.5 group or a COR.sup.6 group, R.sup.3 is a C.sub.1-6 alkyl group, R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl group, R.sup.5 is a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-5 aminoalkyl group, a C.sub.2-7 alkoxy-carbonyl group or a carbamoyl group, and R.sup.6 is a C.sub.1-6 alkyl group or a C.sub.3-8 cycloalkyl group which is unsubstituted or substituted by a halogen atom, an amino group, a cyano group or a straight or branched C.sub.1-6 alkyl group; or a pharmaceutically acceptable salt thereof.
Abstract: The present invention relates to a process for the preparation of aliphatic oligocarbonate diols bya) transesterifying dimethyl carbonate with aliphatic diols in the presence of soluble transesterification catalysts in a gas-liquid countercurrent apparatus to form oligocarbonates until the degree of conversion of the initial dimethyl carbonate is more than 80% andb) removing methanol and traces of dimethyl carbonate in an apparatus which generates gas bubbles in the oligocarbonates until the degree of capping of the terminal OH groups with methoxycarbonyl groups is less than 5%.
Type:
Grant
Filed:
December 15, 1999
Date of Patent:
December 5, 2000
Assignee:
Bayer Aktiengesellschaft
Inventors:
Reinhard Langer, Hans-Josef Buysch, Wieland Hovestadt, Martin Melchiors
Abstract: A unique method for the synthesis of substantially pure .alpha.-keto bisphosphonate esters and the usage of these esters in reactions with C, N, O, or P nucleophiles for synthesis of .alpha.-functionalized bisphosphonates. The method starts with a reaction mixture formed of an .alpha.-diazo methanediphosphonate ester, including tert-butylchlorite, a polar aprotic organic solvent, and an effective amount of water. After synthesis is complete, a water trapping reagent may be added to remove any excess water. The present invention provides a versatile pathway to new .alpha.-substituted bisphosphonate derivatives and could be readily adapted to combinatorial drug discovery synthetic strategies. The .alpha.-keto bisphosphonate esters can be converted to the corresponding acids by acid hydrolysis or mild silyldealkylation.
Type:
Grant
Filed:
July 13, 1999
Date of Patent:
November 14, 2000
Assignee:
University of Southern California University Park
Inventors:
Charles E. McKenna, Boris A. Kashcmirov
Abstract: A process for alkoxylating an organic carbonate wherein an alkylene oxide is reacted with an organic carbonate such as a dialkyl carbonate in the presence of a catalytically effective amount of a calcium-containing catalyst to produce alkoxylated carbonates.
Type:
Grant
Filed:
December 23, 1999
Date of Patent:
November 14, 2000
Assignee:
Condea Vista Company
Inventors:
Upali Weerasooriya, K. Lee Matheson, Dewey L. Smith, Paul A. Filler, Elida G. Partain, Kelly D. Knouse, Janet L. Watson