Patents Examined by Michael G. Hartley
  • Astatine solution and method for producing same
    Patent number: 11684683
    Abstract: The invention provides a method for producing a solution containing 211At? (astatide ion) at a high radiochemical purity by using 211At obtained by a nuclear reaction as a starting material, including a step of adding a reducing agent to a solution containing an impurity derived from 211At. The invention also provides a solution containing 211At? (astatide ion) at a radiochemical purity of not less than 30%.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: June 27, 2023
    Assignee: OSAKA UNIVERSITY
    Inventors: Yoshifumi Shirakami, Tadashi Watabe, Kazuko Kaneda, Eku Shimosegawa, Atsushi Shinohara, Jun Hatazawa
  • Nanoparticle-alginate gels for X-ray imaging of the vasculature
    Patent number: 11672875
    Abstract: Disclosed are capped nanoparticles that are effectively trapped within an aqueous gelling solution to produce stable gels and function as a contrast agent for vascular imaging. The contrast agent has good radioopacity, is inexpensive to produce, and is safe to handle. This provides a new method to image the fine vasculature of biological systems.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: June 13, 2023
    Assignee: Saint Louis University
    Inventors: Sarah McBride-Gagyi, Steven W. Buckner, Paul Jelliss, Mohammad Salauddin Kader
  • Anti-CD33 antibody-guided imaging and treatment of acute myeloid leukemia
    Patent number: 11666672
    Abstract: Disclosed is a non-invasive PET-CT imaging method for detecting acute myeloid leukemia (AML) or extramedullary disease (EMD) in a subject using a radioactive isotope-labeled anti-CD33 antibody. Also disclosed is a PET-CT imaged-guided method for treating AML or EMD.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: June 6, 2023
    Assignee: CITY OF HOPE
    Inventors: Susanta Kumar Hui, Paul J. Yazaki, Srideshikan Sargur Madabushi
  • Compounds for imaging tau proteins that accumulate in brain
    Patent number: 11667628
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: June 6, 2023
    Assignee: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • One-step labeling of antibodies to high specific activity with actinium-225
    Patent number: 11660357
    Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a bio-molecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 30, 2023
    Inventors: David A. Scheinberg, Peter M. Smith-Jones, Michael R. McDevitt, William F. Maguire
  • PSMA-targeting compounds and uses thereof
    Patent number: 11661402
    Abstract: Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
    Type: Grant
    Filed: April 12, 2022
    Date of Patent: May 30, 2023
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Ronnie C. Mease, Ying Chen, Sangeeta Ray
  • Nanoemulsion of iodinated fatty acids for CT imaging
    Patent number: 11654202
    Abstract: An iodinated CT contrast agent made of fatty acid derivatives for non-invasive visualisation and quantification of the brown and/or beige adipose tissue (BAT) or for imaging the heart and/or liver of a subject, to be taken orally which is a breakthrough in CT imaging. Image resolution by CT is significantly enhanced compared to PET.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: May 23, 2023
    Assignee: UNIVERSITY OF GENEVA
    Inventors: Laurent Vinet, Andrej Babic, Eric Allemann
  • System and method to control nucleation of bubbles
    Patent number: 11654205
    Abstract: Generation of bubbles is disclosed to occur within a flow of an aqueous fluid. The bubbles may be formed within a tube of a selected diameter and the bubbles are controlled to exit the tube at a selected diameter. Generally, bubbles are formed to include a diameter of less than 1 millimeter, including less than about 20 microns.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: May 23, 2023
    Assignee: Oakwood Healthcare, Inc.
    Inventor: James Richard Spears
  • Eco-friendly smart photosensitizer and photo-stem cell therapy product comprising same
    Patent number: 11654195
    Abstract: The present invention provides an eco-friendly smart photosensitizer comprising a conjugate of hydroxypropyl methylcellulose and porfimer sodium photosensitizer, and a photo-stem cell therapy product comprising the photosensitizer. The photosensitizer of the present invention can be advantageously used in various fields including anticancer therapy, stem cell therapy, and the like, without side effects.
    Type: Grant
    Filed: November 26, 2020
    Date of Patent: May 23, 2023
    Inventors: Jin Wang Kim, Jung Ok Lee, Hyun Ji Kim, Hyun Woo Kim
  • Treatment of ocular inflammatory diseases using laquinimod
    Patent number: 11654140
    Abstract: Disclosed is a method for treating an ocular inflammatory disease (OID), e.g., uveitis or conjunctivitis, comprising periodic administration of a therapeutically effective amount of laquinimod or a pharmaceutically acceptable salt thereof. Also provided is a pharmaceutical composition comprising laquinimod or a pharmaceutically acceptable salt thereof for use in treating a subject suffering from an OID, uveitis, bacterial conjunctivitis, viral conjunctivitis, an inflammation of the orbital tissue, the lacrimal apparatus, the eyelid, the cornea, the retina or the optic pathway.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 23, 2023
    Assignee: Active Biotech AB
    Inventors: Joel Kaye, Hussein Hallak, Nora Tarcic
  • Unassisted robotic surgery employing paramagnetic halo metallofullerenes as minimally invasive, precision scalpels or micronization particles through magnetic field manipulation and targeted exenteration patterned by programmed 3D imaging using needle or magnetic energy access and microelectronic semiconducting in non-stationary wafer-less space
    Patent number: 11653984
    Abstract: Multi-angle radiographic imaging enables 3D visualization of internal surgical targets like solid-tumors, heart vessels, blocked glands or any bodily cavities like fallopian or Eustachian tubes for diagnostics and surgery planning. Those images are dimensionally precise and easily replicated as life-forms with 3D printing for exact modeling. The “negative” aspects of the images are the diseased tissues requiring excision, as in a solid-tumor example. Needle biopsies are routine and can be radiographically guided. Similarly, guided needle delivery of a magnetic surgical fluid containing fullerenes into a target site, such as a solid tumor is less invasive than laparoscopic techniques. Introducing an external magnetic field force can then be used to propel, rotate and maneuver fullerenes into cellular matter or into tissue.
    Type: Grant
    Filed: August 9, 2022
    Date of Patent: May 23, 2023
    Inventors: Terry Earl Brady, Anthony Lee Dellinger, Lowell Hughes, Melinda K. M. Goddard
  • Double-labeled probe for molecular imaging and use thereof
    Patent number: 11638765
    Abstract: The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 2, 2023
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls -Uni versitaet Heidelberg
    Inventors: Matthias Eder, Klaus Kopka, Martin Schaefer, Ulrike Bauder-Wuest, Uwe Haberkorn, Ann-Christin Eder, Jens Cardinale, Martina Benesova
  • Method for producing organic material microparticles, and method for modifying organic material microparticles
    Patent number: 11633359
    Abstract: Provided are a method for producing organic material microparticles and a method for modifying organic material microparticles, whereby it becomes possible to improve the crystallinity of organic material microparticles or achieve the crystal transformation of the organic material microparticles while preventing the growth of the organic material microparticles in a solvent. A surfactant is added to a solvent that is capable of partially dissolving organic material microparticles, and then the organic material microparticles are reacted with the solvent. In this manner, it becomes possible to improve the degree of crystallization of the organic material microparticles or achieve the crystal transformation of the organic material microparticles without substantially altering the particle diameters of the organic material microparticles.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: April 25, 2023
    Assignee: M. TECHNIQUE CO., LTD.
    Inventors: Masakazu Enomura, Kaeko Araki, Daisuke Honda
  • Nuclear magnetic resonance diagnostic agent, and method for detecting or diagnosing state of cell, tissue or organ in subject using same
    Patent number: 11633505
    Abstract: [Problem] To provide a nuclear magnetic resonance diagnostic agent that has a lower toxicity to organisms and reduced side effects and yet has a site specificity toward a specific cell, tissue, organ, etc. [Solution] When ALA or an ALA derivative is administered in vivo, a metabolite thereof is accumulated in a specific cell, tissue, organ, etc. Focusing on this phenomenon, a nuclear magnetic resonance analysis was performed on a site wherein the metabolite of ALA that had been administered in vivo would be possibly accumulated. As a result, it was surprisingly found that ALA and an ALA derivative are useful as a diagnostic agent whereby the aforesaid problem can be solved.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: April 25, 2023
    Assignees: National University Corporation Kumamoto University, University of Occupational and Enviromental Health, Japan, SBI Pharmaceuticals Co., Ltd.
    Inventors: Tetsuya Yoneda, Shigeru Nishizawa, Junkoh Yamamoto, Tohru Tanaka, Hidenori Itoh
  • Method of synthesizing F radiolabeled biomolecular agents
    Patent number: 11628229
    Abstract: A method for preparing 18F radiolabeled biomolecules and agents for 18F-PET imaging is disclosed herein. A perfluoroaryl-conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified perfluoroaryl-conjugated target tracer is then labeled with 18F using 18F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: April 18, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Mark D. Pagel, Iman Daryaei, Abigail Shepard
  • Engineered chimeric fusion protein compositions and methods of use thereof
    Patent number: 11628218
    Abstract: Compositions and methods for making and using engineered cells, such as, engineered myeloid cells that express a chimeric fusion protein that has a binding domain capable to binding surface molecules on target cells such as diseased cells.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: April 18, 2023
    Assignee: MYELOID THERAPEUTICS, INC.
    Inventors: Daniel Getts, Yuxiao Wang, Bruce McCreedy, Jr.
  • PSMA-binding agents and uses thereof
    Patent number: 11629201
    Abstract: The present invention provides novel compounds that are useful as radiopharmaceuticals, imaging agents and for treatment of cancer.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: April 18, 2023
    Assignees: ITM Isotope Technologies Munich SE, Paul Scherrer Institut
    Inventors: Martina Benesova, Cristina Müller, Christoph Umbricht, Roger Schibli, Konstantin Zhernosekov
  • Long-lived gadolinium based tumor targeted imaging and therapy agents
    Patent number: 11623007
    Abstract: Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula: or a salt therof. R1 includes a chelating agent that is chelated to a gadolinium atom; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl; R2 is —N+H3, —N+H2Z, —N+HZ2, or —N+Z3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: April 11, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jamey Weichert, Anatoly Pinchuk, Wolfgang Axel Tome
  • Bicyclic compounds for diagnosis and therapy
    Patent number: 11623931
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synuclein (?-synuclein, A-synuclein, aSynuclein, A-syn, ?-syn, aSyn) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease. The instant compounds are particularly useful in determining a predisposition to such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament. The present compounds can also be used to treat, alleviate or prevent a disorder or abnormality associated with alpha-synuclein aggregates.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: April 11, 2023
    Assignee: AC IMMUNE SA
    Inventors: Jérôme Molette, Emanuele Gabellieri, Vincent Darmency
  • Pharmaceutical formulations comprising CCR3 antagonists
    Patent number: 11612596
    Abstract: The present invention relates to pharmaceutical compositions containing one or more compounds of formula 1 wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate; j is 1 or 2; and processes for the preparation thereof, and their use to treat diseases connected with the CCR3 receptor.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: March 28, 2023
    Assignee: Alkahest, Inc.
    Inventors: Alfred Fetscher, Jochen Matthias Scher