Abstract: Systems, methods, and devices are provided for assisting or performing guided interventional procedures using custom templates. The system uses pre-procedure scans of a patient's anatomy to identify targets and critical structures. A template is then manufactured containing guide elements. During a procedure, the template may be aligned to the patient and instruments passed though the guide elements and into various targets. The template may be aligned using one or more of, for example, a position sensing system or a live imaging modality to register the patient to the template. The system makes optional use of devices designed to immobilize or track an organ during therapy.

Abstract: An implantable medical device having a sensing module and a control module is configured to receive a cardiac electrical signal and sense events from the cardiac electrical signal received via electrodes carried by a medical electrical lead when the medical electrical lead is coupled to the implantable medical device. The control module coupled is configured to detect non-sustained tachyarrhythmia (NST) episodes based on sensed event intervals and determine if the sensed event intervals during the detected NST episode satisfy oversensing criteria. If the oversensing criteria are satisfied, the control module determines whether the detected NST episode satisfies non-lead related oversensing criteria and withholds a lead integrity alert when the NST episode meeting the oversensing criteria is determined to satisfy non-lead related oversensing criteria.

Abstract: Implantable medical devices including interconnections having strain-relief structure. The interconnections can take the form of flexible circuits. Strain relief gaps and shapes are integrated in the interconnections to relieve forces in each of three dimensions. In some examples, the region of an interconnection which couples with a component of the implantable medical device is separated by a strain relief gap from a connection to a second component and/or a location where the flex bends around a corner.

Abstract: A vitrectomy probe for treating an eye of a patient, the probe including a body arranged for grasping by a surgeon, and a photodisruption element extending from the body. The photodisruption element includes a needle having a main lumen extending from the body, the needle comprising a port at an end, a fiber cannula within the main lumen, the fiber cannula having a fiber lumen, and an optical fiber within the fiber lumen, the optical fiber being mechanically agitatable within the fiber lumen.

Abstract: Devices and methods are disclosed which relate to the detection of cardiovascular efficiency and risk of disease. The rate of volumetric change of the heart can be determined by measuring the parallel conductance across electrodes attached to the heart. Measurements from a lumen would consider the total conductance. The rate of volumetric or lumen cross-section area change can then be compared to an average model to determine the health of a patient.

Abstract: A system and method of treating hyperactivity of an eyelid closing muscle in a subject includes providing a stimulation system in the subject with the hyperactivity of the eyelid closing muscle, sensing an activity of the eyelid closing muscle, and selectively stimulating eyelid opening muscle(s) or innervating nerves, eyelid opening reflexes, or eyelid opening reflexes in non-muscular tissue, using the stimulation system, without substantially activating the eyelid closing muscle. The system and method evokes eyelid movement in the subject.

Abstract: Devices, systems, and methods are disclosed for relaying information from a cardiac pacemaker to an external device. Logic on the pacemaker modulates a heartbeat clock of the pacemaker to encode information onto a blood pressure sequence by adding or subtracting a small subinterval to or from a pulse repetition interval of the pacemaker. A muscle stimulator beats the heart according to the modulated sequence. A monitoring device external to the body monitors the blood pressure to retrieve the encoded information, or message. The encoded information is then decoded to determine the information in the message. This information may concern the pacemaker as well as other devices within the body that communicate with the pacemaker such as blood monitors, etc. Since the message is conveyed via simple modulation of the heart beat intervals, no separate transmitter is required in the pacemaker which would otherwise increase cost and decrease battery life.

Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.

Abstract: A lead fixation device for securing a medical lead in a human patient includes: a single-piece structure comprising: a top surface; a bottom surface; an outer perimeter; and an inner perimeter, the inner perimeter comprising: a diameter approximately equal to or smaller than a diameter of a burr hole into which the lead fixation device is designed to be deployed; a central bore extending longitudinally from the top surface through to the bottom surface, a portion of the central bore being located in approximately a center of the lead fixation device and comprising a central bore diameter; and at least one retention tract formed in the top surface of a cap of the lead fixation device, the retention tract configured for retaining, with an interference fit, a portion of a body of the medical lead in the lead fixation device.

Abstract: A method for measuring and determining a pulse arrival time (PAT) value of a user using a sensor device having a photoplethysmographic (PPG) multichannel sensor formed from a plurality of PPG sensor channels and being adapted to measure a set of PPG signals, each PPG signal being measured by one of the PPG sensor channels when the multichannel PPG sensor is in contact with the user; having: measuring the set of PPG signals; extracting a plurality of features from each of the measured PPG signals; selecting a subset from the set of PPG signals based on the extracted features; and processing the selected subset of PPG signals to determine the PAT value. The disclosed sensor and method can be embedded into a chest belt and do not need skilled supervision. They can represent a potential candidate for the implantation of PWV measurement campaigns in the ambulatory setting.

Abstract: The disclosure provides a method and system for detecting an anaerobic threshold heart rate. After first physiological data, second physiological data and third physiological data are obtained while a user is exercising, an interval of the third physiological data corresponding to an estimated range of first physiological data and a turning point of a curve fitting the third physiological data within the interval are obtained, to determine the anaerobic threshold heart rate of a user.

Abstract: An RF electrode can have a straight shaft to generate an RF heat lesion that is asymmetric about the central axis of the cannula through which the RF electrode is introduced into bodily tissue.

Abstract: An RF electrode can have a straight shaft to generate an RF heat lesion that is asymmetric about the central axis of the cannula through which the RF electrode is introduced into bodily tissue. An electrode can be inserted into a cannula, and an electrosurgical generator can apply current between the active tip of the electrode and the active tip of the cannula to heat tissue.

Abstract: A method for identifying target regions in a tissue for local drug delivery, where functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and where the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery.

Abstract: An optical surgical probe includes a cylindrical cannula; a light guide partially within the cannula to receive a light beam from a light source through a proximal end, to guide the light beam to a distal end of the light guide, and to emit the light beam through the distal end of the light guide; a multi-spot generator at a distal end of the cannula that includes an optical element with a proximal surface to receive the emitted light beam, and a focusing lens, positioned inside the optical element to focus the received light beam into a focused beam, wherein the optical element has a faceted distal surface to split the focused beam into multiple distally emitted beam-components when the optical surgical probe is operated in a fluid with an index of refraction of 1.30-1.40, and to confine the focused beam in the optical surgical probe when the optical surgical probe is operated in air.

Abstract: A blood pressure measuring apparatus and a method of operating the same are provided. The blood pressure measuring apparatus includes: a strap; and a main body that is rotatably connected to the strap, wherein the main body includes: a first pulse wave measurer configured to measure a first pulse wave; a second pulse wave measurer that is spaced apart from the first pulse wave measurer at a regular interval and is configured to measure a second pulse wave; and a blood pressure measurer configured to analyze the first pulse wave and the second pulse wave and determine a blood pressure based on the analyzed first pulse wave and the analyzed second pulse wave.

Abstract: A computer assisted surgical system that includes an apparatus (110) for imaging a region of interest of a portion of an anatomy of a subject; a memory containing executable instructions; and a processor programmed using the instructions to receive two or more two-dimensional images of the region of interest taken at different angles from the apparatus and process the two or more two-dimensional images to produce three dimensional information associated with the region of interest.

Abstract: For saving power in a monitoring system for monitoring physiological data of a patient, motion activity data of the patient is obtained and measurements of physiological data of the patient are initiated, only when the motion activity is both non-zero and below a selected threshold.

Abstract: A magnetic resonance imaging apparatus includes an acquisition unit which acquires first data in which a tissue of interest has higher signal intensity than a background and second data in which the tissue of interest has lower signal intensity than the background, with regard to images of the same region of the same subject, and a generation unit which generates, on the basis of the first data and the second data, third data in which the contrast of the tissue of interest to the background is higher than those in the first and second data.

Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.