Abstract: The present invention provides a method of manufacturing a shoe using a multifunctional primer, comprising the steps of coating a rubber outsole made of unvulcanized rubber with a liquid multifunctional primer comprising a polyurethane dispersion, a butadiene rubber solution, and a natural rubber solution; vulcanizing the unvulcanized rubber outsole coated with the multifunctional primer, thermally activating the coated vulcanized rubber outsole; coating the thermally-activated rubber outsole with an adhesive; and attaching the rubber outsole to a variety of other parts.