Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.

Abstract: An endoscopic surgical instrument is provided. The instrument includes a housing, a handle, an elongated shaft extending distally from the housing and defining a longitudinal axis, an end effector assembly, a drive assembly, a clevis, a first link, and a second link. The end effector assembly is disposed adjacent a distal end of the elongated shaft and includes a first jaw member and a second jaw member. The first link is pivotably connected to the clevis about a first pivot axis, and is pivotably connected to the first jaw member about a first jaw member pivot. The second link is pivotably connected to the clevis about a second pivot axis, and is pivotably connected to the second jaw member about a second jaw member pivot. The first pivot axis and the second pivot axis are offset from the longitudinal axis.

Abstract: Methods, apparatuses and systems are described for preventing the over-tightening of a furled ablation structure support around an expandable member. An ablation device for treatment of tissue in body lumens with varying sizes is disclosed. The ablation device may include a catheter, an expansion member coupled with a distal portion of the catheter, and an ablation structure support configured to at least partially unfurl or furl around the expansion member as the expansion member expands or contracts. The ablation device may further include a spacer coupled with the catheter and configured to limit a minimum diameter of the ablation structure support when the expansion member is completely contracted.

Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.

Abstract: An antenna guide assembly including a guide body having a proximal end defining at least one proximal entry, a distal end defining at least one distal port, and at least one guide passage extending between the proximal and distal ends. The at least one guide passage is configured to receive at least a portion of an antenna therethrough via the at least one proximal entry such that a distal portion of the antenna extends through and distally from the at least one distal port for insertion into tissue. A locking assembly disposed at the distal end of the guide body is configured to receive the distal portion of the antenna therethrough. The locking assembly is configured to selectively engage the distal portion of the antenna to prevent translation of the antenna within the at least one guide passage.

Abstract: An electrosurgical device can have a housing and an electrode defining an energizable surface at least partially positioned externally of the housing. The electrode can move longitudinally relative to the housing. A shank of the electrode can be positioned within the housing and configured to urge against an energizable element in the housing. The energizable element can have a longitudinally movable electrical coupler configured to electrically couple with the shank portion when the shank portion urges against the energizable element. Related methods are also disclosed.

Abstract: A surgical instrument is provided, namely surgical scissors. The surgical instrument has liquid-tight heat-shrunk protective covering located at the business end of the surgical instrument which prevents contamination and damage to moving parts of the instrument which otherwise typically occurs between an extended tube portion of the surgical instrument and a head portion of the surgical instrument. Further, the liquid-tight heat shrunk protective covering provides electrical insulation all the way to the distal tip of a clevis of the surgical instrument by use of a rubber (for example silicone) seal. The surgical instrument has a first blade and a second blade secured to the clevis. The first blade and second blade both have a triangular-shaped back end which allows the blades to fully extend without the back ends extending outside of the instrument.

Abstract: A surgical instrument is provided and includes a housing having a shaft. An end effector assembly operatively connects to the shaft and has a pair of first and second jaw members. A jaw insert is operably associated with the first and second jaw members. The jaw insert includes one or more cam slots defined therein configured to receive a cam pin that upon movement thereof rotates the first and second jaw members from an open position to a clamping position and an opening defined therein configured to securely house a pivot pin that provides a point of pivot for the first and second jaw members. The jaw insert is manufactured from an insulative medium to dielectrically isolate the first and second jaw members.

Abstract: In a method of controlling electrosurgical power delivery based on a comparison of sensed tissue impedance to various impedance threshold values, energy is delivered to tissue in a sealing cycle as a series of pulses. An initial pulse has a profile with a preset energy starting value that increases at a ramping rate to a preset end value. Sensed impedance data are monitored throughout each pulse and compared to an impedance threshold value for RF setpoint, an impedance threshold value for cumulative time, and an impedance threshold value for energy cutback. Based on sensed impedance during a pulse, the profile of a subsequent pulse can be modified. In a high impedance event that reflects low tissue presence, energy may be cutback. A sealing cycle is stopped when a cumulative amount of time with an impedance value over the impedance cumulative time threshold value reaches a sealing cycle duration limit.

Abstract: Example embodiments relate to surgical systems comprising an end-effector assembly and arm assembly. The end-effector assembly may include a first instrument assembly having a first instrument and first instrument driven portion configurable to be driven to move the first instrument relative to a first axis. The arm assembly may include first and second arm assembly bodies, first arm assembly joint portion for joining the first and second arm assembly bodies, first instrument drive assembly, and first arm assembly drive assembly. The first instrument drive assembly may include a first integrated motor and first instrument drive portion controllable by the first integrated motor to drive the first instrument driven portion. The first arm assembly drive assembly may include a second integrated motor and first arm assembly drive portion controllable by the second integrated motor to drive the first arm assembly body to move relative to the second arm assembly body.

Abstract: An electrosurgical energy delivery apparatus includes an energy delivery circuit, a control circuit and an energy-harvesting system with a plurality of energy-harvesting circuits and a voltage regulator that provides a regulated DC voltage to the energy delivery circuit and/or the control circuit. The energy delivery circuit receives an electrosurgical energy signal having a primary frequency and selectively provides the electrosurgical energy signal to an energy delivery element. The control circuit connects to the energy delivery circuit and selectively enables the flow of electrosurgical energy to the energy delivery element. The plurality of energy-harvesting circuits each include an energy-harvesting antenna tuned to a particular frequency, a matched circuit configured to receive an RF signal from the energy-harvesting antenna, rectify the RF signal and generate a DC signal, and an energy storage device that connects to the voltage regulator to receive and store the DC signal.

Abstract: A switch mechanism for a medical manipulator, the switch mechanism including a moveable switching operation part, moving-side contacts provided to the switching operation part, and fixed-side contacts capable of contacting the moving-side contacts. At least the electrical-contact sections of the moving-side contacts and of the fixed-side contacts are formed from a corrosion-resistant material.

Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.

Abstract: In one aspect, a method is provided herein of marking a patient's eye for reference during a toric lens implantation procedure. The method includes providing an electrocautery device having a handle, a shaft extending from the handle, and a tip defined at the terminus of the shaft. The handle is elongated and extends along a longitudinal axis with the shaft being bent or curved such that the tip is spaced from, and not aligned with, the longitudinal axis. The method further includes using the electrocautery device to cauterize one or more points on the patient's eye, the points being located as reference marks for placement of the toric lens. Advantageously, with the subject invention, a device is used having a bent or curved shaft which may better accommodate the curvature of a patient's eye while marking.

Abstract: This invention relates to high-frequency ablation of tissue in the body using a cooled high-frequency electrode connected to a high frequency generator including a computer graphic control system and an automatic controller for control the signal output from the generator, and adapted to display on a real time graphic display a measured parameter related to the ablation process and visually monitor the variation of the parameter of the signal output that is controlled by the controller during the ablation process. In one example, one or more measured parameters are displayed simultaneously to visually interpret the relation of their variation and values. In one example, the displayed one or more parameters can be taken from the list of measured voltage, current, power, impedance, electrode temperature, and tissue temperature related to the ablation process.

Abstract: Electrode placement and connection systems are described which allow for the electrical connection and maintenance of one or more electrodes positioned on a substrate which is subjected to a variety of mechanical stresses. Electrodes may also be formed on flexible circuit assemblies integrated within or along the hood. The circuit assemblies may also provide structural support to the hood during delivery and/or deployment. Such a system may include an imaging hood having an aperture through which transparent fluid is flowed and one or more electrodes positioned along or about the hood. As the hood is configured between a low-profile and opened configuration, these electrodes may remain electrically coupled despite the mechanical stresses subjected to the electrodes and the connections thereto.

Abstract: Provided are a positron emission tomography (PET)-radiofrequency ablation (RFA) complex medical device and a treatment method using the same. According to an aspect of the present invention, there is provided a positron emission tomography (PET)-radiofrequency ablation (RFA) complex medical device comprising: a PET module which obtains, in real time, a location of a target to be treated by scanning a patient; and an RFA module which remotely treats the target using heat by focusing the heat on the location of the target.

Abstract: Methods are provided for monitoring and controlling tissue ablation using RF energy delivered by an imaging ablation catheter under direct visualization, using the control and modulation of a set of ablation parameters based on direct optical imaging of the tissue surface via the imaging ablation catheter, where a set of optical image-derived parameters modulates the setting of a subset of Radio Frequency dosing parameters. The ablation dosing algorithms based on image-derived information can be implemented manually or in semi-automated or automated forms.

Abstract: A surgical instrument is configured to concurrently dissect and coagulate tissue. The surgical instrument includes a handle and a shaft extending distally from the handle. The shaft includes an outer hypotube, a lumen coaxially-disposed within the hypotube and extending beyond a distal end thereof, a coaxial feedline coaxially-disposed within the lumen, and having an inner conductor and an outer conductor disposed coaxially about the inner conductor, and a coolant tube coaxially-disposed between the lumen and the coaxial feedline to form an inflow conduit and an outflow conduit. The instrument further includes a dissecting head assembly coupled to a distal end of the shaft. The dissecting head assembly includes a dielectric core having a substantially planar radiating surface and at least one non-radiating surface, a reflective coating disposed on the at least one non-radiating surface of the dielectric core, and a blade extending from the radiating surface.

Abstract: A treatment system includes a pair of holding members, a high-frequency energy output section, a heat generating section and a control section. At least one of the pair of holding members moves to the other holding member. The high-frequency energy output section and the heat generating section are provided on at least one of the holding members. The high-frequency energy output section exerts high-frequency energy to a living tissue to denature the living tissue, and collects the biological information of the living tissue. The heat generating section applies heat to it held between the holding members, generates the heat owing to the supply of the energy, and conducts the heat therefrom to denature the living tissue. The control section controls the output of the energy to the high-frequency energy output section and the heat generating section based on the biological information collected by the high-frequency energy output section.