Patents Examined by Minh-Tan David
  • Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
    Patent number: 5834597
    Abstract: The invention provides mutated IgG2 constant regions and anti-CD3 antibodies incorporating the same. Such antibodies specifically bind to the CD3 antigen on T-cells but induce reduced mitogenic response compared with otherwise identical antibodies bearing natural IgG2 constant regions. The antibodies can be used for treating disorders requiring immune suppression with fewer side effects than result from treatment with prior anti-CD3 antibodies.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: November 10, 1998
    Assignee: Protein Design Labs, Inc.
    Inventors: J. Yun Tso, Michael S. Cole, Claudio Anasetti