Abstract: This invention relates to devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using ligation-dependent strand displacement amplification technologies in combination with bioelectronic microchip technology.
Type:
Grant
Filed:
May 25, 2001
Date of Patent:
March 8, 2005
Assignee:
Nanogen/Becton Dickinson Partnership
Inventors:
John J. Carrino, Louis O. Gerrue, Jonathan M. Diver
Abstract: The polar surface area of molecules is computed without reference to three dimensional molecular structures using a linear equation incorporating counts of nitrogens, oxygens, and related atom clusters. Methods and systems for predicting intestinal absorption of candidate compounds use the polar surface area and the octanol/water partition coefficient as descriptors.
Abstract: A method for identifying putative peptides of a given function from among nucleotide or peptide sequences of unknown function comprising the steps of:
(i) obtaining a polynucleotide or polypeptide database;
(ii) screening the database for the presence of a combination of nucleotides or amino acids indicative of the peptide of given function;
(ii) identifying the polynucleotide or polypeptide sequences which comprise the combination of nucleotides or amino acids indicative of the peptide of given function.
Type:
Grant
Filed:
February 25, 1999
Date of Patent:
January 14, 2003
Assignees:
Société de Conseils de Recherches et d'Applications
Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S)
Inventors:
Jose Antonio Camara y Ferrer, Christophe Alain Thurieau, Jean Martinez, Gilbert Bergé, Catherine Gozé
Abstract: The present invention relates to a highly accurate and reproducible mathematically-based methodology for quantifying the levels of differential gene expression from microassay protocols. Specifically, the present invention provides a simple deductive approach, grounded in a Bayesian framework, to circumvent the heuristic-based limitation of previous methodologies. Rather than seeking a point-estimate of the fold-change of the level of gene expression, the present invention utilizes the derivation of mathematical formula to determine the a posteriori distribution of all the fold-changes of differential gene expression which may be inferred from the given measurements. From this a posteriori distribution the following information may be obtained: (i) an estimator for the fold-change of the level of gene expression; (ii) confidence limits for the fold-change, at any given confidence level; and (iii) a P-value for assessing the statistical significance of change.
Type:
Grant
Filed:
May 24, 2000
Date of Patent:
December 31, 2002
Assignee:
Aventis Pharmaceuticals
Inventors:
Joachim Theilhaber, Steven Bushnell, Rainer Fuchs