Patents Examined by Monique Cole
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Patent number: 8669111Abstract: The present invention provides reagents and methods for limiting adsorptive and/or oxidative protein losses in a sample.Type: GrantFiled: January 24, 2013Date of Patent: March 11, 2014Assignee: Arizona Board of Regents, A Body Corporate of the State of Arizona Acting for and on Behalf of Arizona State UniversityInventors: Douglas Rehder, Matthew Schaab, Chad Borges
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Patent number: 8668871Abstract: Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor 8 of the present invention uses, as a component for sensing glucose, a sensing device 16 in which a completely synthetic phenylboronic acid compound 21 is bound without using enzymes that have been conventionally used. Consequently, the biosensor 8 can eliminate the problem of protein denaturation to achieve stable performance in sensing glucose, and it is possible to achieve the biosensor 8 can be stored for a long time.Type: GrantFiled: July 20, 2011Date of Patent: March 11, 2014Assignee: National Institute for Materials ScienceInventors: Akira Matsumoto, Yuji Miyahara
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Patent number: 8669113Abstract: The present invention relates to methods, monitors and systems measuring lysophosphatidylcholine, its derivatives and/or procalcitonin as well as at least one clinical marker (e.g. temperature or respiration rate) and/or at least one biomarker for the early detection of sepsis in a subject.Type: GrantFiled: April 2, 2009Date of Patent: March 11, 2014Assignee: Becton, Dickinson and CompanyInventors: Song Shi, Richard L. Moore, James Garrett
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Patent number: 8663998Abstract: According to embodiments of the present application, a color changeable dye can comprise a redox indicator, a reduction reaction initiator, an electron donor, an oxygen scavenger, an indicator barrier agent, a thickening agent and an agent to facilitate mixing. The color changeable dye is a first color in the presence of oxygen, capable of changing to a second color upon reduction in a substantially oxygen free environment, and capable of changing back to the first color after exposure to oxygen for a period of time corresponding to the intended use time of a disposable or limited use product. Methods of making and using the color changeable dye and apparatuses incorporating such dye are also disclosed.Type: GrantFiled: December 9, 2011Date of Patent: March 4, 2014Inventors: Gregory Lee Heacock, Dion Arledge Rivera
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Patent number: 8658430Abstract: The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.Type: GrantFiled: July 20, 2012Date of Patent: February 25, 2014Assignee: Raindance Technologies, Inc.Inventors: Benjamin J. Miller, Qun Zhong, Darren Roy Link
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Patent number: 8658428Abstract: In at least one embodiment, the invention is directed to a method of determining the nitrogen content in nitrocellulose by High Performance Liquid Chromatography (HPLC). It is within the scope of the invention for the sample of nitrocellulose to be unstable nitrocellulose, unrefined nitrocellulose, or refined nitrocellulose. The sample of nitrocellulose can wet or dry. A sample of nitrocellulose that is wet can be in acid or in water. Before HPLC, the sample is dissolved in a suitable solvent. The nitrogen content of the sample is determined by comparing the retention time of the sample to a graph of retention time to amount of nitrogen due to the linear correlation of retention time and percent nitrogen substitution.Type: GrantFiled: July 1, 2011Date of Patent: February 25, 2014Assignee: Alliant Techsystems Inc.Inventor: Michael T. Combs
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Patent number: 8652417Abstract: A set of crystallization solutions includes a plurality of crystallization solutions of Crystallization Solution Set I, a plurality of crystallization solutions of Crystallization Solution Set II or a plurality of crystallization solutions of Crystallization Solution Set III.Type: GrantFiled: January 20, 2011Date of Patent: February 18, 2014Assignee: Microlytic APSInventor: Morten Sommer
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Patent number: 8647878Abstract: The invention relates to an immersion liquid including at least one compound of the general formula I in which R1 and R2 each include at least one ring structure and X denotes: O, S, NR3 with R3 selected from hydrogen or hydrocarbon, wherein Y denotes independently of each other O, S or NR4 with R4 selected from hydrogen or hydrocarbon. In addition, the invention relates to a further immersion liquid, a compound for an immersion liquid and a use of the immersion liquids or of the compound as an immersion oil for a microscope, in particular for a near-field microscope.Type: GrantFiled: February 24, 2010Date of Patent: February 11, 2014Assignee: Carl Zeiss AGInventor: Hans-Joachim Weippert
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Patent number: 8647565Abstract: The multifunctional paint is based on a highly porous inorganic substance created by a reaction of at least two components. TiO2 nanoparticles are attached to the surface of this substance. The first component is a water insoluble calcium compound and the second component is a water soluble sulfate. The method of applying the multifunctional paint on the surface is that the first component containing the water suspension of the insoluble calcium compound is applied on the treated area first and subsequently a mixture of TiO2 nanoparticles suspended in the water solution of the second component is applied over the first layer. Another way is to apply a water suspension of the first component containing also TiO2 nanoparticles on the treated surface and then deposit the water solution of the second component on the layer. A mixture of all components can be also applied on the treated area at once.Type: GrantFiled: December 8, 2008Date of Patent: February 11, 2014Assignee: Advanced Materials—JTJ S.R.O.Inventors: Jan Procházka, Jr., Jan Procházka, Sr.
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Patent number: 8642343Abstract: Provided is a blood separating agent that can form an excellent partition wall in an intermediate layer between clot and serum or between blood cell components and plasma even under low-temperature centrifugation conditions, is less likely to form crevices in the partition wall, is less likely to have any effect on test values, and offers stable performance even after long-term storage. The blood separating agent contains: a polymer for the blood separating agent which is composed of a (meth)acrylic acid ester-based polymer and has a viscosity of 10 to 200 Pa·s at 25° C. and a ratio of viscosity at 15° C. to viscosity at 25° C. of below 4.6; an inorganic powder; and a polyalkylene glycol having a number average molecular weight of 700 or more, wherein the polyalkylene glycol is mixed at a concentration of 5% by weight or less of the total weight of the blood separating agent.Type: GrantFiled: February 15, 2011Date of Patent: February 4, 2014Assignee: Sekisui Medical Co., Ltd.Inventors: Tomonori Inoue, Ryusuke Okamoto
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Patent number: 8636953Abstract: A SAW sensor includes a substrate, first and second IDT on the substrate and a detector portion between the first and second IDT. The first IDT generates a surface acoustic wave in response to a high-frequency signal input. The second IDT receives the SAW from the first IDT, and converts the SAW to an electric signal and outputs the electric signal. A one pulse signal, which is input to the first IDT electrode, has an applying time that is at least as long as a delay time of a surface acoustic wave at the detector less an arrival time of a direct wave attributable to electromagnetic coupling between the first IDT and the second IDT electrode, and that is less than an arrival time at the second IDT of a third response wave of the surface acoustic wave from the first IDT.Type: GrantFiled: March 28, 2013Date of Patent: January 28, 2014Assignee: Kyocera CorporationInventor: Hiroshi Katta
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Patent number: 8636954Abstract: The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the array of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e.Type: GrantFiled: November 22, 2004Date of Patent: January 28, 2014Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Yu Ge, Wenjun Yang, Shuying Zhao, Lianghong Guo, Jing Cheng
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Patent number: 8628589Abstract: More stable and valuable bio-oil produced from biomasses are provided. More specifically, more stable and valuable bio-oil useful as heating oil is provided. Particularly, various embodiments of the present invention provide for a bio-oil having sufficient heating value and stability to be useful as heating oil without the need to hydrotreat the bio-oil or use a similar deoxygenating process.Type: GrantFiled: February 11, 2011Date of Patent: January 14, 2014Assignee: KiOR, Inc.Inventors: Maria Magdalena Ramirez Corredores, Vicente Sanchez
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Patent number: 8628976Abstract: Methods for detecting particles in a fluid, including determining particle size and intrinsic fluorescence of a particle, and time correlating the particle detection data with image data in the vicinity of the detector or detector inlet to identify contamination sources in clean environments are described.Type: GrantFiled: December 3, 2008Date of Patent: January 14, 2014Assignee: Azbil Biovigilant, Inc.Inventors: Charles E. Bolotin, Martin Van Trieste
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Patent number: 8623281Abstract: Disclosed is a semiconductor device (1) for determining NO concentrations in fluids such as exhaled breath. The device (1) typically comprises a pair of electrodes (18) separated from each other to define a channel region (16) in an organic semiconductor (14), a gate structure (10) for controlling said channel region, and a receptor layer (22) at least partially overlapping said channel region, said receptor layer comprising a porphine or phtalocyanine coordination complex including a group III-XII transition metal ion or a lead (Pb) ion for complexing NO. Such a semiconductor device is capable of sensing NO concentrations in the ppb range.Type: GrantFiled: December 10, 2009Date of Patent: January 7, 2014Assignee: Koninklijke Philips N.V.Inventors: Sepas Setayesh, Nicolaas Petrus Willard, Dagobert Michel De Leeuw
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Patent number: 8623290Abstract: The present invention relates to a color-changing material and to a multiple-component material that includes a color-changing composition. The color-changing materials and color-changing compositions are capable of changing color in order to indicate a change in condition, such as a change in pH. The color-changing materials and color-changing compositions include a hydrogel-forming composition, a charged colorant and a pH adjuster. The hydrogel-forming composition includes at least one charged species.Type: GrantFiled: September 4, 2012Date of Patent: January 7, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Xuedong Song, Kaiyuan Yang, Stephanie M. Martin, Maia Bageant
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Patent number: 8623655Abstract: The invention provides a serum or plasma separating composition which can compensate for the lack of initial thixotropy even at a reduced inorganic powder concentration and in which crevices or the like are less likely to be created in a partition wall formed of the separating composition after being centrifuged. The serum or plasma separating composition contains a liquid resin component having a partition wall-forming capability, a hydrophilic inorganic powder, a hydrophobic inorganic powder, and an organic compound serving as a thixotropy enhancer, wherein the organic compound is a polyalkylene glycol and/or a derivative thereof and is made of at least one type of polymer.Type: GrantFiled: January 25, 2011Date of Patent: January 7, 2014Assignee: Sekisui Medical Co., Ltd.Inventors: Hideo Anraku, Masatoshi Niunoya
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Patent number: 8623292Abstract: A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa ?10?3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (?1 wt. % solute) in water and aqueous solutions of low ionic concentration of ?0.1 wt. % salts, but insoluble (<1 wt.Type: GrantFiled: August 17, 2010Date of Patent: January 7, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Xuedong Song, Ning Wei, Ronnie L. Phillips
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Patent number: 8617896Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.Type: GrantFiled: June 21, 2012Date of Patent: December 31, 2013Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
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Patent number: 8617900Abstract: Co-topo-polymeric indicator compositions and methods for making and using the same are provided. Indicator compositions of the invention include a polymer and undergo a color change, which may be reversible or irreversible, in response to an applied stimulus, e.g., temperature. Aspects of methods of producing the compositions include setting a fluid co-topo-polymeric precursor composition into a solid product and then subjecting the solid product (either immediately or after a delay period) to polymerizing conditions to produce the desired indicator composition. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.Type: GrantFiled: April 27, 2012Date of Patent: December 31, 2013Assignee: Segan Industries, Inc.Inventor: Hans O. Ribi