Patents Examined by Monique Cole
  • Patent number: 8669111
    Abstract: The present invention provides reagents and methods for limiting adsorptive and/or oxidative protein losses in a sample.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: March 11, 2014
    Assignee: Arizona Board of Regents, A Body Corporate of the State of Arizona Acting for and on Behalf of Arizona State University
    Inventors: Douglas Rehder, Matthew Schaab, Chad Borges
  • Patent number: 8668871
    Abstract: Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor 8 of the present invention uses, as a component for sensing glucose, a sensing device 16 in which a completely synthetic phenylboronic acid compound 21 is bound without using enzymes that have been conventionally used. Consequently, the biosensor 8 can eliminate the problem of protein denaturation to achieve stable performance in sensing glucose, and it is possible to achieve the biosensor 8 can be stored for a long time.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: March 11, 2014
    Assignee: National Institute for Materials Science
    Inventors: Akira Matsumoto, Yuji Miyahara
  • Patent number: 8669113
    Abstract: The present invention relates to methods, monitors and systems measuring lysophosphatidylcholine, its derivatives and/or procalcitonin as well as at least one clinical marker (e.g. temperature or respiration rate) and/or at least one biomarker for the early detection of sepsis in a subject.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: March 11, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Song Shi, Richard L. Moore, James Garrett
  • Patent number: 8663998
    Abstract: According to embodiments of the present application, a color changeable dye can comprise a redox indicator, a reduction reaction initiator, an electron donor, an oxygen scavenger, an indicator barrier agent, a thickening agent and an agent to facilitate mixing. The color changeable dye is a first color in the presence of oxygen, capable of changing to a second color upon reduction in a substantially oxygen free environment, and capable of changing back to the first color after exposure to oxygen for a period of time corresponding to the intended use time of a disposable or limited use product. Methods of making and using the color changeable dye and apparatuses incorporating such dye are also disclosed.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: March 4, 2014
    Inventors: Gregory Lee Heacock, Dion Arledge Rivera
  • Patent number: 8658430
    Abstract: The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 25, 2014
    Assignee: Raindance Technologies, Inc.
    Inventors: Benjamin J. Miller, Qun Zhong, Darren Roy Link
  • Patent number: 8658428
    Abstract: In at least one embodiment, the invention is directed to a method of determining the nitrogen content in nitrocellulose by High Performance Liquid Chromatography (HPLC). It is within the scope of the invention for the sample of nitrocellulose to be unstable nitrocellulose, unrefined nitrocellulose, or refined nitrocellulose. The sample of nitrocellulose can wet or dry. A sample of nitrocellulose that is wet can be in acid or in water. Before HPLC, the sample is dissolved in a suitable solvent. The nitrogen content of the sample is determined by comparing the retention time of the sample to a graph of retention time to amount of nitrogen due to the linear correlation of retention time and percent nitrogen substitution.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: February 25, 2014
    Assignee: Alliant Techsystems Inc.
    Inventor: Michael T. Combs
  • Patent number: 8652417
    Abstract: A set of crystallization solutions includes a plurality of crystallization solutions of Crystallization Solution Set I, a plurality of crystallization solutions of Crystallization Solution Set II or a plurality of crystallization solutions of Crystallization Solution Set III.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: February 18, 2014
    Assignee: Microlytic APS
    Inventor: Morten Sommer
  • Patent number: 8647878
    Abstract: The invention relates to an immersion liquid including at least one compound of the general formula I in which R1 and R2 each include at least one ring structure and X denotes: O, S, NR3 with R3 selected from hydrogen or hydrocarbon, wherein Y denotes independently of each other O, S or NR4 with R4 selected from hydrogen or hydrocarbon. In addition, the invention relates to a further immersion liquid, a compound for an immersion liquid and a use of the immersion liquids or of the compound as an immersion oil for a microscope, in particular for a near-field microscope.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: February 11, 2014
    Assignee: Carl Zeiss AG
    Inventor: Hans-Joachim Weippert
  • Patent number: 8647565
    Abstract: The multifunctional paint is based on a highly porous inorganic substance created by a reaction of at least two components. TiO2 nanoparticles are attached to the surface of this substance. The first component is a water insoluble calcium compound and the second component is a water soluble sulfate. The method of applying the multifunctional paint on the surface is that the first component containing the water suspension of the insoluble calcium compound is applied on the treated area first and subsequently a mixture of TiO2 nanoparticles suspended in the water solution of the second component is applied over the first layer. Another way is to apply a water suspension of the first component containing also TiO2 nanoparticles on the treated surface and then deposit the water solution of the second component on the layer. A mixture of all components can be also applied on the treated area at once.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: February 11, 2014
    Assignee: Advanced Materials—JTJ S.R.O.
    Inventors: Jan Procházka, Jr., Jan Procházka, Sr.
  • Patent number: 8642343
    Abstract: Provided is a blood separating agent that can form an excellent partition wall in an intermediate layer between clot and serum or between blood cell components and plasma even under low-temperature centrifugation conditions, is less likely to form crevices in the partition wall, is less likely to have any effect on test values, and offers stable performance even after long-term storage. The blood separating agent contains: a polymer for the blood separating agent which is composed of a (meth)acrylic acid ester-based polymer and has a viscosity of 10 to 200 Pa·s at 25° C. and a ratio of viscosity at 15° C. to viscosity at 25° C. of below 4.6; an inorganic powder; and a polyalkylene glycol having a number average molecular weight of 700 or more, wherein the polyalkylene glycol is mixed at a concentration of 5% by weight or less of the total weight of the blood separating agent.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: February 4, 2014
    Assignee: Sekisui Medical Co., Ltd.
    Inventors: Tomonori Inoue, Ryusuke Okamoto
  • Patent number: 8636953
    Abstract: A SAW sensor includes a substrate, first and second IDT on the substrate and a detector portion between the first and second IDT. The first IDT generates a surface acoustic wave in response to a high-frequency signal input. The second IDT receives the SAW from the first IDT, and converts the SAW to an electric signal and outputs the electric signal. A one pulse signal, which is input to the first IDT electrode, has an applying time that is at least as long as a delay time of a surface acoustic wave at the detector less an arrival time of a direct wave attributable to electromagnetic coupling between the first IDT and the second IDT electrode, and that is less than an arrival time at the second IDT of a third response wave of the surface acoustic wave from the first IDT.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: January 28, 2014
    Assignee: Kyocera Corporation
    Inventor: Hiroshi Katta
  • Patent number: 8636954
    Abstract: The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the array of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: January 28, 2014
    Assignees: CapitalBio Corporation, Tsinghua University
    Inventors: Yu Ge, Wenjun Yang, Shuying Zhao, Lianghong Guo, Jing Cheng
  • Patent number: 8628589
    Abstract: More stable and valuable bio-oil produced from biomasses are provided. More specifically, more stable and valuable bio-oil useful as heating oil is provided. Particularly, various embodiments of the present invention provide for a bio-oil having sufficient heating value and stability to be useful as heating oil without the need to hydrotreat the bio-oil or use a similar deoxygenating process.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: January 14, 2014
    Assignee: KiOR, Inc.
    Inventors: Maria Magdalena Ramirez Corredores, Vicente Sanchez
  • Patent number: 8628976
    Abstract: Methods for detecting particles in a fluid, including determining particle size and intrinsic fluorescence of a particle, and time correlating the particle detection data with image data in the vicinity of the detector or detector inlet to identify contamination sources in clean environments are described.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: January 14, 2014
    Assignee: Azbil Biovigilant, Inc.
    Inventors: Charles E. Bolotin, Martin Van Trieste
  • Patent number: 8623281
    Abstract: Disclosed is a semiconductor device (1) for determining NO concentrations in fluids such as exhaled breath. The device (1) typically comprises a pair of electrodes (18) separated from each other to define a channel region (16) in an organic semiconductor (14), a gate structure (10) for controlling said channel region, and a receptor layer (22) at least partially overlapping said channel region, said receptor layer comprising a porphine or phtalocyanine coordination complex including a group III-XII transition metal ion or a lead (Pb) ion for complexing NO. Such a semiconductor device is capable of sensing NO concentrations in the ppb range.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: January 7, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Sepas Setayesh, Nicolaas Petrus Willard, Dagobert Michel De Leeuw
  • Patent number: 8623290
    Abstract: The present invention relates to a color-changing material and to a multiple-component material that includes a color-changing composition. The color-changing materials and color-changing compositions are capable of changing color in order to indicate a change in condition, such as a change in pH. The color-changing materials and color-changing compositions include a hydrogel-forming composition, a charged colorant and a pH adjuster. The hydrogel-forming composition includes at least one charged species.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: January 7, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Kaiyuan Yang, Stephanie M. Martin, Maia Bageant
  • Patent number: 8623655
    Abstract: The invention provides a serum or plasma separating composition which can compensate for the lack of initial thixotropy even at a reduced inorganic powder concentration and in which crevices or the like are less likely to be created in a partition wall formed of the separating composition after being centrifuged. The serum or plasma separating composition contains a liquid resin component having a partition wall-forming capability, a hydrophilic inorganic powder, a hydrophobic inorganic powder, and an organic compound serving as a thixotropy enhancer, wherein the organic compound is a polyalkylene glycol and/or a derivative thereof and is made of at least one type of polymer.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: January 7, 2014
    Assignee: Sekisui Medical Co., Ltd.
    Inventors: Hideo Anraku, Masatoshi Niunoya
  • Patent number: 8623292
    Abstract: A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa ?10?3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (?1 wt. % solute) in water and aqueous solutions of low ionic concentration of ?0.1 wt. % salts, but insoluble (<1 wt.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: January 7, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Ning Wei, Ronnie L. Phillips
  • Patent number: 8617896
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: December 31, 2013
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Patent number: 8617900
    Abstract: Co-topo-polymeric indicator compositions and methods for making and using the same are provided. Indicator compositions of the invention include a polymer and undergo a color change, which may be reversible or irreversible, in response to an applied stimulus, e.g., temperature. Aspects of methods of producing the compositions include setting a fluid co-topo-polymeric precursor composition into a solid product and then subjecting the solid product (either immediately or after a delay period) to polymerizing conditions to produce the desired indicator composition. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: December 31, 2013
    Assignee: Segan Industries, Inc.
    Inventor: Hans O. Ribi