Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.

Abstract: Compounds of the formula: ##STR1## wherein A is S, SO, or SO.sub.2, R.sup.1 is H or acyl, R.sup.2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R.sup.3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

Abstract: A compound of the formula (I): ##STR1## wherein the ring A is a pyrrole ring which may be hydrogenated, X is an amino group, a hydroxyl group or a mercapto group, Y is a hydrogen atom or a hydroxyl group, --COOR.sup.1 and --COOR.sup.2 may be the same or different and are a carboxyl group which may be esterified, --B-- is a divalent heterocyclic group or a lower alkylene group each of which may be substituted, and Z is a straight C.sub.2-4 divalent group which may be substituted, or its salt, a method for the production of the same and an antitumor agent containing the same.

Abstract: Phenyl substituted heterocyclic compounds having insecticidal activity have the formula (I): ##STR1## wherein R.sup.1 is an optionally substituted pyridone, thiopyridone, pyrimidinthione, pyrimidinone, pyrazole, imidazole or triazole group; R.sup.2 is hydrogen, halogen, haloalkyl, nitro, cyano or a group --CX--NY.sup.1 Y.sup.2 ; R.sup.3 and R.sup.5 are hydrogen, halogen, alkyl or cycloalkyl; R.sup.4 is halogen, haloalkyl, haloalkoxy or S(O).sub.n R.sup.6 ; and Y.sup.1 and Y.sup.2 are independently selected from hydrogen, nitro, amino or optionally substituted alkyl or Y.sup.1 and Y.sup.2 together with the nitrogen to which they are attached form an aliphatic heterocyclic group or form the group .dbd.CHY.sup.3 or Y.sup.1 is hydrogen and Y.sup.2 is alkoxycarbonyl, alkylcarbonyl, optionally substituted aralkyl or --S(O).sub.n R.sup.6.

Abstract: The present invention provides a compound of the formula: ##STR1## process for their production, pharmaceutical compositions containing them and their pharmaceutical uses, and intermediates useful for their production and processes for the production of such intermediates.

Abstract: New heterocyclic compounds of formula I ##STR1## in which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 -- group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrogen or lower alkyl or R.sub.1 and R.sub.2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 mean independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.

Abstract: The invention relates to the addition product formed from the reaction of a tertiary amino substituted alkyl lactam having the formula ##STR1## and a haogenated silicone having the formulae ##STR2## wherein m has a value of from 1 to 3; n has a value of from 1 to 100; r has a value of from 0 to 3, R.sub.14 is ##STR3## or R.sub.15R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 andR.sub.15 are each individually alkyl, alkoxy, haloalkyl, phenyl, benzyl, haloalkyl-phenyl, halophenyl or mixtures thereof and wherein at least one of said substituents bonded to a silicon atom is a radical having a haloalkyl group;R is alkylene having from 3 to 8 carbon atoms, optionally substituted with lower alkyl, carboxyl, halo or ##STR4## R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are each independently lower alkyl and p has a value of from 1 to 6.

Abstract: The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R.sup.1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group which may have one or more substituents selected from halogen, lower alkyl, lower alkoxy and phenyl,R.sup.2 and R.sup.3 are each lower alkyl, aryl or ar-(lower)alkyl, or R.sup.2 and R.sup.3 are together to form 1,3-dithian ring,R.sup.4 is hydrogen or lower alkoxy, andn is O or an integer 1 to 4 and pharmaceutically acceptable salts thereof.

Abstract: A process for producing a photoreceptor is disclosed. A gaseous compound of the constituent materials of the photoreceptor is decomposed by glow discharge in the presence of a metal, thereby forming a constituent layer containing atoms and or ions of the metal.