Patents Examined by Nathan A. Bowers
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Patent number: 11891648Abstract: Disclosed are methods and systems for rapidly testing antimicrobial susceptibility, wherein the qualitative and quantitative susceptibility of an inoculated microorganism against an antimicrobial agent or a combination of antimicrobial agents is determined as a function of one or more slopes of linear trends ? of data of readouts.Type: GrantFiled: July 16, 2019Date of Patent: February 6, 2024Inventors: Pawel Debski, Piotr Garstecki
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Patent number: 11884938Abstract: The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.Type: GrantFiled: November 19, 2019Date of Patent: January 30, 2024Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Hyun Jung Kim
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Patent number: 11872554Abstract: A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.Type: GrantFiled: March 9, 2020Date of Patent: January 16, 2024Assignee: ABBOTT DIAGNOSTICS SCARBOROUGH, INC.Inventors: Alexander Schenk zu Schweinsberg, Austin Matthew Derfus, Justin Davidson, Karthikeyan Kumaravadivelu, Maulik Vinod Patel, Olaf Piepenburg, Catherine Jean Greenwood, Oliver Nentwich
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Patent number: 11872191Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.Type: GrantFiled: March 24, 2021Date of Patent: January 16, 2024Assignee: Alcresta Therapeutics, Inc.Inventors: Alexey L. Margolin, Robert Gallotto, Bhami Shenoy
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Patent number: 11872550Abstract: A safety cabinet includes a work space where work is performed; a front panel disposed in a front surface of the work space; and an air cleaner that cleans air to be supplied to the work space. An imaging device is disposed on one side surface side of side surfaces of the work space, and a connection opening is disposed on the other side surface side facing one side surface.Type: GrantFiled: June 29, 2020Date of Patent: January 16, 2024Assignee: Hitachi Industrial Equipment Systems Co., Ltd.Inventors: Takeshi Kaneko, Takeshi Matsumura
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Patent number: 11859164Abstract: Scalable biomaterial-based bioreactors are described. In one embodiment, the bioreactor may comprise perforated plates stacked such that the assembled bioreactor has the necessary manifolds and chambers to transport gas and liquids to a biomaterial contained within the bioreactor, and to remove the reaction products. In another embodiment, single use bioreactors are described. Methods of operating the bioreactors are also described.Type: GrantFiled: April 14, 2021Date of Patent: January 2, 2024Assignee: Battelle Memorial InstituteInventors: Zia Abdullah, Michael L. Dickens, Micah Paul McCreery, Randy L. Jones, Elvin Ray Beach, III, Jon-David S. Sears, Erin Suzanne Schultz, Stephanie Ann Smith, Paul E. George, II
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Patent number: 11844345Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.Type: GrantFiled: August 2, 2018Date of Patent: December 19, 2023Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Tamer I. Khayal, Paul Lezberg
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Patent number: 11820719Abstract: A system and a method for treating biomass with a gas includes at least one conduit having at least one biomass inlet and at least one biomass outlet, at least one gas inlet and at least one gas outlet. The system further includes a transport unit configured to move the biomass through the conduit from the at least one biomass inlet to the at least one biomass outlet thereby defining a biomass transport direction. The system is configured such that gas flowing from the at least one gas inlet to the at least one gas outlet crosses the biomass transport direction.Type: GrantFiled: February 2, 2018Date of Patent: November 21, 2023Assignee: Advanced Substrate Technologies A/SInventor: Svend Hoff
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Patent number: 11821824Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.Type: GrantFiled: September 18, 2017Date of Patent: November 21, 2023Assignee: TISSUE GENESIS INTERNATIONAL LLCInventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
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Patent number: 11807842Abstract: A system and method for array system for cells, organoids and organs culture and testing. The system includes a disposable chips and systems with actuators, sensors, software/firmware and smart device App. The disposable includes standard well plates, custom well plates, T-flasks, microfluidic chips. The system includes vascular fluidics using gravity-driven flow and pneumatic flow, media, reagents, protein and collagen dispensers in wells or surfaces, manufacturing techniques for multi-layer chips and plates and culture system with gas and media control.Type: GrantFiled: September 30, 2020Date of Patent: November 7, 2023Assignee: Biopico Systems IncInventor: John Collins
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Patent number: 11806718Abstract: The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently.Type: GrantFiled: October 7, 2021Date of Patent: November 7, 2023Assignee: HANDYLAB, INC.Inventors: Kalyan Handique, Sundaresh N. Brahmasandra
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Patent number: 11795428Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating in a loop reactor which utilize substantially vertical flow zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.Type: GrantFiled: January 9, 2018Date of Patent: October 24, 2023Assignee: CALYSTA, INC.Inventors: Luan Thanh Nguyen, Joshua A. Silverman
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Patent number: 11776284Abstract: A device and a process to count a number of colonies present in a set of samples. The colony counting device has a storage device with plural storage locations. A handling system is operative to convey samples to analyze from storage locations to an analysis area and from the analysis area to storage locations. An imaging device is operative to acquire a plurality of images of a sample to analyze, the plurality of images including all or a part of the analysis area. A processing unit is operative to implement, for each sample to analyze, a detection step to detect the presence of colonies by analyzing an image of the plurality of images of the sample and a determination step to determine the number of colonies present in the sample by counting the colonies whose presence have been detected during the detection step.Type: GrantFiled: November 18, 2020Date of Patent: October 3, 2023Assignee: INTERSCIENCEInventor: Emmanuel Jalenques
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Patent number: 11767497Abstract: Systems, devices, and methods for producing a tissue specimen and performing subsequent biomechanical testing thereof to quantify various biological/physiological properties and characteristics. The system may include a bioreactor device for producing the tissue specimen which includes a packaged/sealed seeding cup containing a scaffold in a sterile environment amenable to seeding with cells. After seeding, the cup may be stored in a standard laboratory culture tray for incubation. The produced tissue specimen may next be transferred to a testing instrument under control of a microcontroller which automatically performs a series of tests on the tissue and generates testing data communicated to an external electronic device which can operably interact with and control operation in part of the testing instrument via software. Tissue integrity in the instrument may be maintained by sterile fluid circulation and heating systems.Type: GrantFiled: July 28, 2020Date of Patent: September 26, 2023Inventors: Warren Greenway, Darren Harris, Aydin Akyol
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Patent number: 11760968Abstract: An incubator (1) and its use for cultivating microorganisms and/or for carrying out a chemical reaction are provided. The incubator (1) has a sample vessel holder (3) for insertion of a sample vessel (4), a heating device (5) for changing a temperature in the sample vessel holder (3) and/or in a sample vessel (4) inserted into the sample vessel holder (3), and a sample-inactivating device (6) for inactivation of a sample (7) in a sample vessel (4) that is inserted into the sample vessel holder (3).Type: GrantFiled: March 19, 2018Date of Patent: September 19, 2023Assignee: TESTO SE & CO. KGAAInventor: Joel Riemer
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Patent number: 11761024Abstract: A system that indicates the presence or absence of microorganisms in fluid food products. The system has a bottle for receiving sample to be tested. The bottle has a sensor that will monitor and detect changes in at least one sample parameter, but no additives that contain nutrients that support microbial growth. The bottle is placed in an incubator and the sensor in the bottle is monitored for changes. The incubator is programed so that, if the sensor detects that the value of the monitored parameter has reached a certain value, then the sample is determined to be positive for microbial growth.Type: GrantFiled: November 5, 2020Date of Patent: September 19, 2023Assignee: BECTON DICKINSON HOLDINGS PTE LTD.Inventors: Xiao Li, Yan Zhang, Jianwei Liu
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Patent number: 11753350Abstract: The disclosure relates to a composting device including a housing defining an interior with an access opening providing access to the interior, a composter bin located within the interior and in communication with the access opening, and a cover slidably mounted to the housing and slidable along a sliding path between opened and closed conditions to selectively open and close the access opening. A seal assembly comprising a seal depending from one of the cover or the housing and a sealing surface provided on the other of the cover or housing about the access opening. The seal arranged such that a space between the seal and the sealing surface decreases as the cover is slid from the opened to the closed condition, and the seal abuts and compresses against the sealing surface in the closed condition to seal the cover relative to the housing.Type: GrantFiled: December 21, 2020Date of Patent: September 12, 2023Assignee: Whirlpool CorporationInventors: Abhishek Buzruk, Christopher C. Wilcox, Brian Clark
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Patent number: 11732233Abstract: A tissue processing system for dissociation of and release of cellular components from adipose tissue to prepare stromal vascular fraction includes a portable tissue processing unit for containing biological material including adipose tissue during enzymatic digestion processing and a digestion drive unit configured to receive the tissue processing unit for rotational processing of the tissue processing unit about an axis of rotation. The unit has an upright orientation and a reclined orientation in which the axis of rotation is at a reclined angle to horizontal relative to the upright orientation. The digestion drive unit is configured to receive and drive rotation of the tissue processing unit in the reclined orientation. Methods for processing biological material including adipose tissue include enzymatically digesting adipose tissue with rotation of a tissue processing unit around an axis of rotation in a reclined orientation.Type: GrantFiled: January 23, 2018Date of Patent: August 22, 2023Assignee: GID BIO, Inc.Inventors: William W. Cimino, Thomas Michael Johannsen, David Joe Wesley, Dale William Tomrdle
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Patent number: 11708553Abstract: The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.Type: GrantFiled: June 7, 2018Date of Patent: July 25, 2023Assignee: University of Maryland, Baltimore CountyInventors: Govind Rao, Yordan Kostov, Abhay Andar, Mustafa Al-Adhami, Sevda Deldari, Douglas D. Frey
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Patent number: 11685889Abstract: The present disclosure provides automated modules and instruments for improved detection of nuclease genome editing of live cells. The disclosure provides improved modules—including high throughput modules—for screening cells that have been subjected to editing and identifying and selecting cells that have been properly edited.Type: GrantFiled: April 30, 2022Date of Patent: June 27, 2023Assignee: INSCRIPTA, INC.Inventors: Andrew Garst, Richard Fox, Eileen Spindler, Amy Hiddessen, Phillip Belgrader, Don Masquelier, Bruce Chabansky, Michael Graige