Abstract: Catheter systems configured for emergency blood-vessel occlusion and associated devices, systems, and methods are disclosed herein. A catheter system configured in accordance with a particular embodiment includes a catheter, a sheath, and an extracorporeal proximity sensor. The catheter includes an elongated body having a tip, a sealing portion, and a main shaft proximal to the sealing portion. The tip is configured to dilate a blood vessel ahead of the distal end portion of the sheath as the catheter and the sheath are advanced together through the blood vessel. The distal end portion of the sheath is configured to fit snugly around the sealing portion. The catheter further includes a balloon and a proximity-sensor target less than about 10 centimeters from the balloon. The proximity sensor is configured to receive a signal from the proximity-sensor target to aid in positioning the balloon without fluoroscopic guidance.

Abstract: A medical device assembly may include a stylet having a distal stylet body and a proximal stylet hub, a cannula having a distal cannula body and a proximal cannula hub, and a lock for securing the stylet to the cannula, wherein the lock includes at least one abutment on at least one of the stylet hub and the cannula hub for restricting relative movement between the stylet hub and the cannula hub.

Abstract: A Coude catheter insures proper drainage and reduces tissue damage by using a loop section having an open passageway positioned on a proximal end of the catheter to adjust the catheter.

Abstract: The present disclosure provides an apparatus for intracranial drug injection including a body unit having a through-hole extending between a first opening in a topmost surface and a second opening in a bottommost surface, a cap unit having a shape corresponding to at least a part of an inner surface of the through-hole and being inserted into the first opening to cover the first opening, and a tube unit having one end coupled to the second opening and another end extending toward an affected brain lesion.

Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.

Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

Abstract: A low-cost medical pump for ambulatory use provides an improved IV line cartridge attachment allowing for single handed, low force release while preventing inadvertent IV line cartridge release. A rotatable side lever minimizes the force required to move the locking elements against a spring biased force urging the locking elements to a locking position.

Abstract: An implantable containment apparatus for receiving and retaining a biological moiety or a therapeutic device within a tissue bed is disclosed. The device includes a shaping element to maintain the device in a generally toroidal configuration and to return the apparatus to that configuration after deformation. The apparatus can be placed in a host tissue with minimal trauma to the patient. Methods for implanting and using the apparatus are also disclosed.

Abstract: An exchangeable cartridge for an injection device is disclosed. The cartridge (3) comprises a container (4) and a plunger (10) connectable with a plunger rod (9). The container receives the plunger rod from its rear end. The plunger comprises a rod connector (12) connectable with a front portion (13), and the rod connector has a base portion (24), an outer wall section (15), an inner wall section (16), and a rod stop portion (17) encircled by the inner wall section. The inner wall section comprises several tongues (22) protruding rearwards from the base portion and defining an entrance opening (18) for the plunger rod. The inner wall section receives a front portion (13) of the plunger rod through the entrance, and the tongues are provided with retaining portions arranged to retain the front end portion during retraction of the plunger rod within the housing.

Abstract: Described here are devices, systems, and methods for forming a fistula between two blood vessels. Generally, the systems may comprise a first catheter and a second catheter, which may comprise one or more fistula-forming elements. The first and second catheters may comprise one or more magnetic elements, which may be used to assist in bringing the first and catheters in closer proximity to facilitate fistula formation. In some variations, the magnetic elements may have magnetization patterns such that the flux generated by the magnetic elements is locally concentrated. In some instances, the system may comprise a magnetic control device, which may comprise a magnet, and may be used to increase or create an attractive force between the first and second catheters.

Abstract: A fluid pressure gun device for a balloon catheter includes a tubular cavity, a fluid tube, a pressure monitoring device, a plunger, a screw structure, a cover and a detent structure, wherein inside the body of the cavity forms a chamber. The plunger is disposed in the chamber, and the inside of the casing forms a chamber. The screwing structure includes two screwing blocks, and each screwing block is oppositely arranged in the chamber according to the plunger as the center. Each of the screw blocks is screwed with the plunger, and a plurality of springs respectively lean against the screw block and the cover. The detent structure is used to depart the screw blocks from the plunger. The plunger is supported by each screw block at least on two opposite sides, and making it a highly reliable combination of the plunger and each screw block.

Abstract: There is provided an infusion set capable of significantly reducing a period of time required for work of a worker during infusion. The infusion set includes a drip chamber, a tube which is connected to an outlet of the drip chamber, a roller clip which is provided in the tube, and an M clamp which is provided between the drip chamber and the roller clip in the tube and is used for storing liquid in the drip chamber. The tube has a first tube which can be mounted to an infusion pump device, a second tube which is connected to the outlet of the drip chamber and an inlet of the first tube, and a third tube which is connected to an outlet of the first tube. The M clamp is provided in the second tube, and the roller clip is provided in the third tube.

Abstract: A patient temperature control system for automated temperature control according to a programmed protocol. In one aspect, at least one programmed protocol may be established for each of a plurality of patient thermal therapy phases. In turn, the temperature of a thermal exchange medium may be controlled upon the programmed protocol during each of the phases. A plurality of programmed protocols may be established, wherein a selected protocol may be utilized for automated temperature control during patient thermal therapy. The protocol may include a target patient temperature and/or a set duration for one or more of the phase of thermal therapy. The protocol may be user-definable and modifiable during therapy. In a multiphase configuration, automatic termination and initiation of successive phases may be selectively established by a user, based on target patient temperature data and/or set duration data on a phase-specific basis.

Abstract: A splittable sheath includes a splittable sheath body, a splittable sheath hub, and a valve element. The sheath body comprises a generally flexible tubular structure, a proximal end, and a distal end. The sheath body defines a longitudinal axis and is splittable into two halves along a pre-determined line generally parallel to the longitudinal axis. The sheath hub extends from the proximal end of the sheath body and defines a longitudinal axis generally aligned with the longitudinal axis of the sheath body. The sheath body and sheath hub form an inner cavity along their respective longitudinal axes. The valve element includes a resilient plate and a sealing element. The resilient plate includes a distal portion extending radially inwardly from a side of the inner cavity.

Abstract: The present disclosure provides an apparatus including: (a) a frame (102) having a first end (104) and a second end (106), wherein the frame includes a plurality of struts (108) arranged between the first end and the second end of the frame, (b) a plurality of channels (110) disposed within the plurality of struts of the frame, (c) an infusion balloon (112) coupled to the frame and arranged such that, in an expanded condition, the frame provides a plurality of openings (114) that the infusion balloon is configured to expand through and extend radially outward from the frame, thereby defining a plurality of grooves (116), (d) a plurality of holes (118) defined in the frame and configured to permit fluid communication between the plurality of channels and the plurality of grooves, and (e) an infusion hub (120) arranged at the first end or the second end of the frame including a reservoir in fluid communication with the plurality of channels.

Abstract: A modular connector assembly for a medical container may include a plurality of covers and a plurality of adapters. Each cover is connectable to a cooperatively dimensioned medical container. Each adapter is attachable in fluid sealing engagement with each cover by an interface assembly including a first interface segment formed on each of said plurality of covers and a second interface segment formed on each of said plurality of adapters. The first and second interface segments and corresponding ones of the covers and adapters are initially separable and subsequently connected to define a fluid sealing engagement between connected ones of the cover and adapter. The structural configuration of each of the plurality of adapters is variable to define a different one of a plurality of medical connector types.

Abstract: Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

Abstract: A fluid pumping system may comprise a pump and a fluid line state detector having, a receptacle, at sensor, and an illuminator. The system may further comprise a fluid transfer set including an output line for mating into the receptacle. The system may further comprise a controller in data communication with the fluid line state detector configured to power the illuminator and monitor an output signal of the sensor when the outlet line is in the receptacle to determine a dry tube light intensity value. The controller may be further configured to govern operation of the pump to prime the output line with fluid. The controller may be further configured to power the illuminator, monitor the output signal, and halt operation of the pump when the output signal indicates the light intensity value has dropped below a primed line threshold which is dependent upon the dry tube intensity value.

Abstract: The present disclosure includes an expandable medical device and outer sheath combination. The outer sheath is capable of being split to form multiple sheath sections that may be peeled back to expose a portion or all of the expandable medical device. The medical device, as well as the outer sheath, may include one or more therapeutic agents for delivery to a treatment area within a patient.

Abstract: A medical fluid suspension generating apparatus for performing medical procedures includes a Venturi-agitating tip assembly composed of a multi-channel arrangement at a proximal first end thereof and a tip at a distal second end thereof. The apparatus also includes a compressed medical fluid unit fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly and a medical solution fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly. Pressurized gas, from the compressed medical fluid unit, and the medical solution are combined within the Venturi-agitating tip assembly in a manner generating an enriched medical suspension that is ultimately dispensed from the suspension delivery apparatus.