Abstract: A method for preparing granules. A slurry containing solid API powder particles dispersed in a liquid is prepared. The slurry is fed to a granulator and mixed with a dry base powder within the granulator in order to produce a slurry/base powder mixture. The slurry/base powder mixture produced within the granulator is dried in order to obtain granules containing the solid API particles and the base powder.
Type:
Grant
Filed:
August 30, 2018
Date of Patent:
December 19, 2023
Assignee:
Novartis AG
Inventors:
Markus Krumme, Hans De Waard, Klaus-Peter Moll, Adrian Schmidt, Julien Taillemite
Abstract: A solid oral pharmaceutical composition is disclosed, which comprises: a first active ingredient, which is pitavastatin or a pharmaceutically acceptable salt thereof; a second active ingredient, which is ezetimibe or a pharmaceutically acceptable salt thereof; and at least one excipient, including a diluent, a stabilizing agent, a disintegrant, a binding agent, a sweetener, a lubricant, a glidant, a flavor, a coloring agent or a combination thereof.
Type:
Grant
Filed:
August 5, 2021
Date of Patent:
December 5, 2023
Assignee:
ORIENT PHARMA CO., LTD.
Inventors:
Chien-Yu Chen, David Wong, Mongkol Sriwongjanya
Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.
Type:
Grant
Filed:
October 7, 2022
Date of Patent:
November 21, 2023
Assignees:
Trustees of Boston University, The General Hospital Corporation
Inventors:
Eric M. Bressler, Sarah Adams, Yolonda Colson, Mark W. Grinstaff, Wilson Wai Chun Wong
Abstract: According to the invention there is provided a method of improving (e.g. restoring) function in a patient having idiopathic pulmonary fibrosis, which method comprises perorally administering a therapeutically-effective amount of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically acceptable salt thereof, to said patient. Said treatment is capable of treating said IPF in a therapeutic, including a curative, fashion.
Abstract: The present invention provides for an oral liquid suspension that includes quetiapine or a pharmaceutically acceptable salt thereof. Also provided is a method for orally delivering quetiapine fumarate to a subject (e.g., for treating a mental disorder in a subject, such as schizophrenia, bipolar mania, and/or bipolar depression). The method includes orally administering to the subject an oral liquid suspension described herein.
Abstract: Lyophilized formulations of tegavivint, methods of making such formulations, and methods of treatment of cancer by administering the formulations.
Abstract: A exhausted-tobacco tablet that includes a solid solution of soluble fiber and one or more sugar alcohols, the solid solution having a glass transition temperature of less than 40° C., and exhausted-tobacco is dispersed in the solid solution, and one or more additives dispersed in the solid solution such that at least one additive is released from the tablet when the tablet is chewed or dissolved within an adult tobacco consumer's oral cavity.
Type:
Grant
Filed:
October 3, 2014
Date of Patent:
October 10, 2023
Assignee:
Altria Client Services LLC
Inventors:
Feng Gao, Diane L. Gee, Shuzhong Zhuang, Phillip M. Hulan, William J. Burke
Abstract: The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.
Type:
Grant
Filed:
April 2, 2021
Date of Patent:
October 3, 2023
Assignee:
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: A nicotine tablet that includes a solid solution of soluble fiber and one or more sugar alcohols, the solid solution having a glass transition temperature of less than 40° C., and nicotine or a derivative thereof dispersed in the solid solution such that the nicotine or derivative thereof is released from the tablet when the tablet is chewed or dissolved within an oral cavity.
Type:
Grant
Filed:
October 3, 2014
Date of Patent:
October 3, 2023
Assignee:
Altria Client Services LLC
Inventors:
Feng Gao, Diane L. Gee, Shuzhong Zhuang, Phillip M. Hulan, William J. Burke
Abstract: A process is provided for encapsulating glutathione (GSH), 3,3?-diindolylmethane (DIM), coenzyme-Q10 (CoQ10), and other hydrophobic antioxidant compounds by using whey proteins which may be polymerized in a particular manner. Further, compositions comprising polymerized whey protein (PWP) encapsulated glutathione, polymerized whey protein (PWP) encapsulated CoQ10, and polymerized whey protein (PWP) encapsulated DIM are provided.
Type:
Grant
Filed:
August 17, 2021
Date of Patent:
September 26, 2023
Assignee:
FoodScience Corporation
Inventors:
Adam Killpartrick, Mingruo Guo, Alyssa Humphrey Kemp
Abstract: The present invention relates to a stable pharmaceutical formulation comprising omeprazole, its enantiomer, or its pharmaceutically acceptable salt, and sodium bicarbonate, and a method for preparing the same. Specifically, the present invention provides a stable formulation by preventing omeprazole, its enantiomer, or its pharmaceutically acceptable salt, from coming in direct contact with sodium bicarbonate, to reduce the production of impurities.
Type:
Grant
Filed:
January 28, 2019
Date of Patent:
September 19, 2023
Assignee:
CHONG KUN DANG PHARMACEUTICAL CORP.
Inventors:
Jong Seo Choi, Min Soo Kim, Shin Jung Park, Jong Lae Lim
Abstract: A powder preparation for nasal administration containing a particulate of steroid hormones having an average particle size of 50 to 300 ?m as an active ingredient is prepared.
Abstract: Disclosed herein is an analgesic solution for the treatment of pain comprising a pain-relieving effective amount of tramadol or a pharmaceutically acceptable salt thereof, a method of treating pain by administering said analgesic solution to a subject in need thereof, a kit that includes containers of the analgesic solution, and a dosing regimen for the analgesic solution.
Type:
Grant
Filed:
June 14, 2021
Date of Patent:
September 12, 2023
Assignee:
ATHENA BIOSCIENCE, LLC
Inventors:
H. Greg Thomas, Richard LeVasseur, Jeffrey S. Kiel
Abstract: The present invention discloses a microcapsule powder stable in gastric acid, a method for preparing the same and use thereof. The microcapsule powder comprises a core material and a capsule material coated outside the core material, wherein the capsule material has a melting point of greater than 42° C., and the capsule material does not decompose or dissolve under the action of protease and gastric acid, but decomposes under the action of intestinal digestive enzymes. The core material is coated with the capsule material in the microcapsule powder, thus achieving high-efficiency coating of the core material by a single component. The microcapsule powder achieves conventional intragastric stability as well as favorable stability in an open environment at room temperature, thus solving the problem that the conventional embedding solution may only achieve intragastric stability, but the stability in an open environment at room temperature is low.
Abstract: The invention relates to a solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication.
Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.
Type:
Grant
Filed:
November 12, 2020
Date of Patent:
August 8, 2023
Assignee:
NANEXA AB
Inventors:
Jan-Otto Carlsson, Anders Johansson, Marten Rooth
Abstract: The invention discloses particular water-dispersible solid formulation of a cannabinoid or a cannabis extract, wherein they are present in the form of a nanoemulsion, and upon dispersion in water said formulation produces nanoparticles (droplets of a submicron size) with an average size of up to about 500 nm. The present disclosure further relates to methods of making thereof, as well as therapeutic applications in humans for treating disorders and broader application for a range of medical conditions.
Type:
Grant
Filed:
March 11, 2019
Date of Patent:
August 1, 2023
Assignee:
Karnak Technologies, LLC
Inventors:
Shlomo Magdassi, Liraz Larush, Rafael Ezra
Abstract: Provided herein are stable amlodipine liquid formulations. Also provided herein are methods of using amlodipine liquid formulations for the treatment of certain diseases including hypertension and Coronary Artery Disease (CAD).
Abstract: Disclosed is a curcumin nanoparticle, including curcumin as core material and a wall material, where a weight ratio of the curcumin to the wall material is (5.5-7.5):100, and the wall material includes gum arabic and zein in a weight ratio of (1-5):5. The disclosure further provides a method of making the curcumin nanoparticle and a curcumin beverage containing the curcumin nanoparticle.
Abstract: Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.
Type:
Grant
Filed:
June 11, 2021
Date of Patent:
July 4, 2023
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Eve Montia, Dwayne Looney, Theresa Scheuble, Ronen Eavri, Roi Mashiach