Patents Examined by Oluwatosin A Ogunbiyi
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Patent number: 11963991Abstract: Disclosed herein are compositions having standardized potencies for use in the treatment of warts. Methods of treating a common wart comprising administering one or more intralesional injections of compositions having standardized potencies to a patient in need thereof are also disclosed. Further disclosed are methods of treating a non-common wart administering one or more intralesional injections of compositions having standardized potencies to a patient in need thereof.Type: GrantFiled: April 21, 2023Date of Patent: April 23, 2024Assignee: Nielsen BioSciences, Inc.Inventor: H. Stewart Nielsen, Jr.
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Patent number: 11964002Abstract: The present invention relates to the field of recombinant protein production in a host cell. More specifically the invention relates to the field of oral protein delivery. Specifically, the invention provides oral pharmaceutical formulations comprising the culture medium of a recombinant host secreting a recombinant protein. The resulting oral pharmaceutical formulations are useful for the treatment of gastro-intestinal and/or buccal disorders. Additionally, the oral pharmaceutical formulations are useful for prophylactic and vaccine purposes.Type: GrantFiled: February 28, 2018Date of Patent: April 23, 2024Assignees: VIB VZW, Universiteit GentInventors: Nico Callewaert, Robin Vanluchene, Bram Laukens, Anna Depicker, Vikram Virdi
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Patent number: 11957148Abstract: The invention relates to a mixture of human milk oligosaccharides and composition comprising thereof, that consists essentially of: LNnT, LNT, 2?-FL, 3?-SL, 6?-SL and either DFL or 3-FL, preferably DFL, that can be useful for preventing and/or treating viral and/or bacterial infections in a human.Type: GrantFiled: December 15, 2016Date of Patent: April 16, 2024Assignee: Societe des Produits Nestle S.A.Inventors: Bruce McConnell, Louise Kristine Vigsnaes
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Patent number: 11957743Abstract: A Streptococcus suis (S. suis) vaccine is provided. For the S. suis vaccine, an antigen is a protein with an amino acid sequence shown in SEQ ID NO: 2. A preparation method of the S. suis vaccine is provided, including the following steps: mixing a white oil and aluminum stearate to obtain a white oil adjuvant; adding poly sorbate 80 to an aqueous solution of the protein with the amino acid sequence shown in SEQ ID NO: 2, and thoroughly mixing to obtain an antigen solution; and mixing the antigen solution with the white oil adjuvant according to a volume ratio of (0.5-1.5):2, and emulsifying to obtain the S. suis vaccine. An animal immunized with the S. suis vaccine of the present disclosure can effectively resist the attack of S. suis serotype 2, 3, and 31, with a vaccine protection rate as high as 100%.Type: GrantFiled: June 10, 2022Date of Patent: April 16, 2024Assignee: JIANGSU ACADEMY OF AGRICULTURAL SCIENCESInventors: Qi Xiao, Xialing Zhao, Hongjie Fan, Xiaoguo Huang, Wenxian Qian, Libin Wen, Haodan Zhu, Yanxiu Ni, Junming Zhou, Dandan Wang, Jiaqiang Niu, Kongwang He
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Patent number: 11951162Abstract: The present invention provides an immunogenic composition comprising a Streptococcus pneumoniae polysaccharide-protein conjugate, comprising a capsular polysaccharide derived from one or more selected from the group consisting of serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F, derived from Streptococcus pneumoniae; and one or 2 or more of carrier proteins conjugated to the respective capsular polysaccharide, and method of preparation thereof. Through one example of the present invention, an immunogenic composition for preventing or treating pneumococcal infection can be provided.Type: GrantFiled: April 18, 2019Date of Patent: April 9, 2024Assignee: SK BIOSCIENCE CO., LTD.Inventors: Hun Kim, Dong Soo Ham, Jin-Hwan Shin, Kyung-jun An, Sung-hyun Kim
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Patent number: 11951127Abstract: The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.Type: GrantFiled: June 22, 2018Date of Patent: April 9, 2024Assignees: THE WESTMEAD INSTITUTE FOR MEDICAL RESEARCH, THE UNIVERSITY OF SYDNEY, WESTERN SYDNEY LOCAL HEALTH DISTRICT, NEW SOUTH WALES HEALTH PATHOLOGYInventors: Emily Blyth, Leighton Clancy, David Gottlieb, Kenneth Micklethwaite
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Patent number: 11938178Abstract: The present invention relates to improved epicutaneous administration methods for vaccination of a subject. In particular, the present invention discloses the use of an antigen for epicutaneous immunization, wherein the antigen is administered by epicutaneous application with a skin patch device in combination with an epidermal skin treatment.Type: GrantFiled: July 9, 2019Date of Patent: March 26, 2024Assignees: DBV TECHNOLOGIES, BIONET-ASIA CO., LTDInventors: Hong Thai Pham, Nathalie Donne, Pierre-Louis Herve, Lucie Mondoulet
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Patent number: 11932683Abstract: The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.Type: GrantFiled: September 14, 2022Date of Patent: March 19, 2024Assignee: NEW YORK UNIVERSITYInventors: Victor J. Torres, Tamara Reyes-Robles, Francis Alonzo
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Patent number: 11920124Abstract: The present disclosure relates to a method of producing lactic acid bacteria dual-coated with protein and polysaccharide by using a protein hydrolysate, and lactic acid bacteria having a dual coating, produced by the method. The lactic acid bacteria having a dual coating of protein and polysaccharide, produced according to the present disclosure, have very excellent dry-freezing viability, acid resistance and bile resistance. Accordingly, the lactic acid bacteria having a dual coating of protein and polysaccharide according to the present disclosure will be very useful for the production of fermented milk, processed milk, fermented soy products, processed foods, functional beverages, functional foods, common foods, etc.Type: GrantFiled: April 3, 2020Date of Patent: March 5, 2024Assignee: CELL BIOTECH CO., LTD.Inventor: Myung Jun Chung
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Patent number: 11911449Abstract: This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.Type: GrantFiled: May 18, 2021Date of Patent: February 27, 2024Assignee: REVANCE THERAPEUTICS, INC.Inventors: Stewart A. Thompson, Curtis L. Ruegg, Jacob M. Waugh
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Patent number: 11897941Abstract: The present disclosure relates to compositions and methods for inhibiting bacterial aggregation, and in particular, to compositions and methods that inhibit autotransporter-mediated bacterial aggregation or attachment. Described herein are autotransporter binding molecules such as antibodies and antigen binding fragments thereof. The autotransporter binding molecules block self-association between autotransporters and autotransporter-mediated surface attachment.Type: GrantFiled: February 22, 2021Date of Patent: February 13, 2024Assignees: La Trobe University, The University of QueenslandInventors: Begona Heras, Jason Paxman, Mark Schembri, Alvin Lo
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Patent number: 11897942Abstract: The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.Type: GrantFiled: May 24, 2019Date of Patent: February 13, 2024Assignees: Temple University—Of The Commonwealth System of Higher Education, LANKENAU INSTITUTE OF MEDICAL RESEARCHInventors: Cagla Tukel Wilson, Scott Dessain
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Patent number: 11891598Abstract: The present invention relates to a host cell, which comprises under the control of a heterologous promoter a polynucleotide comprising a nucleotide sequence encoding a polypeptide capable of synthesizing a polysaccharide consisting of a dimeric repeating unit as well as to a vaccine composition comprising such host cell. Furthermore, either such host cell or a polypeptide expressed by such host cell is used for the production of a polysaccharide consisting of a dimeric repeating unit which may be used as a glycoconjugate vaccine.Type: GrantFiled: July 26, 2018Date of Patent: February 6, 2024Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)Inventors: Timm Fiebig, Christa Litschko, Rita Gerardy-Schahn, Andrea Bethe, Monika Berger
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Patent number: 11883502Abstract: The present invention provides a method of producing a polysaccharide-protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation step prior to filtration to remove free polysaccharide.Type: GrantFiled: December 7, 2021Date of Patent: January 30, 2024Assignee: Merck Sharp & Dohme LLCInventors: Michael Albert Winters, John E. MacNair
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Patent number: 11885803Abstract: In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×106 cells/mL, less than about 3×106 cells/ml, less than about 1×106 CFU/mL, or less than about 50 ?g/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.Type: GrantFiled: February 16, 2022Date of Patent: January 30, 2024Assignee: The Regents of the University of CaliforniaInventors: Daniel Takashi Kamei, Yin To Chiu, Benjamin Ming Wu, Garrett L. Mosley
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Patent number: 11857613Abstract: In certain embodiments, the present invention provides a poultry vaccine comprising an antigenic protein comprising a PlcC protein unit that is operably linked to a peptide linker that is operably linked to a NetB protein unit, where the vaccine is effective in stimulating a protective cellular and/or humoral immune response to C. perfringens. Methods are also provided for making the vaccine and for vaccinating poultry by administering such a vaccine.Type: GrantFiled: December 27, 2022Date of Patent: January 2, 2024Assignee: ARIZONA BOARD OF REGENTS ON BEHALF ARIZONA STATE UNIVERSITYInventors: Kenneth Roland, Andrew Diamos, Hugh Mason
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Patent number: 11857612Abstract: Combination therapeutics for the treatment of cancer include the use of immune effector cells, IL-15 based superagonists and one or more immunotherapeutic agents such as Bacillus Calmette-Guerin (BCG).Type: GrantFiled: December 15, 2022Date of Patent: January 2, 2024Assignee: NantCell, Inc.Inventor: Patrick Soon-Shiong
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Patent number: 11860163Abstract: The present invention relates to compositions, methods, and kits for predicting a subject's response to a CAR T cell therapy, by analyzing the intestinal microbiome of the subject. The present disclosure also provides a method of detecting patients at risk for a poor response to CAR T cell therapy by measuring the level of the presently disclosed bacteria or bacterial genes in the microflora or microbiome of a patient receiving or considered for CAR T cell therapy. The present disclosure further provides therapeutic compositions and methods for treating a subject having a cancer, by improving the subject's response to a CAR T cell therapy.Type: GrantFiled: April 13, 2021Date of Patent: January 2, 2024Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTERInventors: Melody Smith, Marcel van den Brink, Eric Pamer, Eric Littmann
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Patent number: 11839649Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.Type: GrantFiled: January 22, 2021Date of Patent: December 12, 2023Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, The United States Government as represented by the Department of Veterans AffairsInventors: Gayatri Vedantam, Virinchipuram K. Viswanathan, Michael Mallozzi
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Patent number: 11827911Abstract: The present description relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA.Type: GrantFiled: May 24, 2021Date of Patent: November 28, 2023Assignee: The Rockefeller UniversityInventors: Vincent A Fischetti, Anu Daniel, Chad Euler