Abstract: The present invention is directed to an integrated microsystem and method for detecting biomolecules in a liquid sample. The integrated microsystem is made up of a sensor that includes microelectrodes connected to a matrix of carbon nanotubes deposited on a substrate, a micropump, a microcontroller for regulating the sample delivery, a signal processor for analyzing the sensor signal, a microheater that surrounds the carbon nanotube sensor, and microfluidic channel formed by a polydimethylsiloxane (PDMS) silicone elastomer cap containing a trench with the cap aligned with the carbon nanotube sensor. The method includes using the integrated microsystem to detect the presence of a biomolecule based on changes in the electrical conductance or resonant frequency of the carbon nanotube matrix.

Abstract: The present invention is directed to a method of using a near-infrared (NIR) model to predict the amount of accessible carbohydrate material in a feedstock sample. The NIR model is generated by subjecting a set of biomass calibration feedstock samples to near infrared spectroscopy which produces NIR spectroscopic data, measuring the chemical compositions of each said calibration feedstock sample by wet chemical techniques, and measuring the total amount of monosaccharides and disaccharides solubilized by each said calibration feedstock sample after processing under a defined pretreatment condition or defined enzyme load condition. The method is then applied to NIR spectral data obtained from a test feedstock sample to predict the amount of accessible carbohydrate material in the test feedstock sample.

Abstract: The present invention relates to a method for measuring physical property values of a cell based on dielectric spectroscopy and based on modeling electrical characteristics such as electric conductivity, electric permittivity, dielectric constant change, and dielectric relaxation expressions in order to obtain membrane capacitance and cytoplasmic conductivity values of the cell.

Abstract: A computational method for generating a feeding score for an individual infant based upon a comparison of feeding factor measurements obtained from the individual infant, values associated with the feeding factor measurements, and feeding parameter metrics from a population of infants having a similar gestational age as the individual infant.

Abstract: The present invention relates to a method and system for standardizing a test microarray dataset. The method requires obtaining a test microarray dataset comprising abundance values for a first plurality of cellular constituents, providing a standardization data structure associated with values of central tendency and identifies, and applying the standardization data structure to the test microarray dataset using a mathematical transformation in order to produce a standardized test microarray dataset. This change has been made for purposes of compact prosecution and to better embrace the allowable subject matter.

Abstract: A method and/or system for analyzing data using population clustering through density based merging.

Abstract: A method of adjusting amplification curves in a PCR experiment includes receiving a plurality of amplification curves for a sample and computing a first parameter for each of the plurality of amplification curves. The method also includes computing a second parameter for each of the plurality of amplification curves and computing a third parameter using at least a portion of the first or second parameters. The method further includes computing an offset for each of the plurality of amplification curves. The offset is a function of the first parameter and the third parameter. Moreover, the method includes adjusting at least one of the plurality of amplification curves by subtracting the offset.

Abstract: The present invention provides methods and compositions for identifying a subject in a fatigued state, a subject recovering from a fatigued state and/or a subject having an increased likelihood of performing a physical activity at a sufficient level by detecting and/or quantitating, in a sample from the subject, one or more biomarkers associated with fatigue and/or physical performance capability.

Abstract: A novel numerical and graphical representation has been developed to better comprehend the physicochemical, biological and pharmacokinetic properties of drug-like compounds. Abbreviated profile of drug (A-POD) would help in considering and visualizing the various compound characteristics as one entity. The salient features of A-POD are: a unique way of representing the compound properties, computer friendly numerical string representation making comparison of any properties possible, graphical representation that gives a snapshot of properties and their relative changes, and its usefulness in qualitatively predicting the ADMET properties based on chemical properties alone. This simple yet powerful web-based tool is especially useful in comparing any two compounds at one time. A new therapeutic agent can be compared with the reference compound quickly and easily, by checking which properties are affected and finding out whether it possesses better drug-like properties.

Abstract: The invention provides compositions and methods for performing primer extension reactions, including employment of amplification primers having 5? tags to incorporate into amplicons variant nucleotides of interest from target nucleic acids at known ratios, with or without sequences surrounding the variant nucleotides of interest. The invention provides identifying the variant nucleotides generated from the target nucleic acid and generated from the 5? tags, comparing the results, evaluating the efficiency of the primer extension reactions, and monitoring the efficacy of such reactions. The invention accounts for DNA sequence and experimental variables that may affect efficiency of incorporation of nucleotides, and provides a reference point for the interpretation of polymorphisms. The invention also provides methods of breeding scrapie-resistant sheep populations.