Abstract: Organochlorosilanes are produced by reacting, in a fluidized bed reactor, a chloromethane-containing reactant gas with a particulate contact mass containing silicon and a catalyst, wherein the organochlorosilanes have the general formula (CH3)nHSiCl4-n-m where n=1 to 3 and m=0 or 1, wherein the process is characterized by three dimensions indices K1-K3, which are respectively associated with the reactor, the contact mass, and the reaction conditions, and which are maintained within specified bounds.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
September 26, 2023
Assignee:
Wacker Chemie AG
Inventors:
Karl-Heinz Rimboeck, Michael Mueller, Natalia Sofina
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
Type:
Grant
Filed:
June 24, 2022
Date of Patent:
September 19, 2023
Assignee:
Merck, Sharp & Dohme LLC
Inventors:
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
Type:
Grant
Filed:
June 24, 2022
Date of Patent:
September 19, 2023
Assignee:
MERCK SHARP & DOHME LLC
Inventors:
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
Type:
Grant
Filed:
August 16, 2022
Date of Patent:
September 19, 2023
Assignee:
CureVac Manufacturing GmbH
Inventors:
Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
Abstract: A natural hydrocolloid system can be used in, e.g., pet food compositions. Another aspect of the present disclosure is pet food compositions comprising such a natural hydrocolloid system, and preparation methods thereof. The hydrocolloid system can use blends of fruit fibers, such as citrus and apple fibers, and/or plant-based polysaccharides, such as psyllium, okra, chia, flaxseed, or seaweed; and can provide a gravy and even a jelly with functionalities comparable to the existing gravies. The blends can replace currently used hydrocolloids and can be used in new recipes with natural and clean labels.
Type:
Grant
Filed:
September 20, 2021
Date of Patent:
September 19, 2023
Assignee:
SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Inventors:
Paulo Alexandre Braga Fernandes, Lisa Petit
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
Type:
Grant
Filed:
June 24, 2022
Date of Patent:
September 19, 2023
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Abstract: A ruthenium compound represented by a general formula described in the specification, a raw material which is for forming a thin film and which contains the ruthenium compound, and a method of producing a thin film using the raw material for forming a thin film are provided.
Abstract: A method of making a cobalt compound for feed supplements includes the steps of dissolving cobalt acetate tetrahydrate in water to form a mixture, adding an acid to the mixture, sonicating the mixture for a selected time, removing acetic acid from the mixture, and separating crystals of the cobalt compound from the mixture.
Abstract: The present invention relates to an N-palmitoyl-D-glucosamine-based composition in a micronized form, optionally in combination with Curcumin. In particular, the present invention relates to N-palmitoyl-D-glucosamine in a micronized or co-micronized form with Curcumin. Such a product can be formulated in human or veterinary pharmaceutical compositions, dietetic products, food supplements, or foods for special medical purposes (FSMP), or in feeds, or nutritional supplements for animals for the treatment of chronic systemic inflammatory diseases, in humans and animals, resulting from dysfunctions of epithelia and synovial membranes.
Type:
Grant
Filed:
June 17, 2021
Date of Patent:
September 5, 2023
Assignee:
Innovet Italia S.R.L.
Inventors:
Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo, Sofia Parrasia, Salvatore Cuzzocrea
Abstract: This disclosure features compounds and compositions that are useful in methods of treating coronavirus infections (e.g., useful in methods of treating COVID-19) in a subject in need thereof. The methods include administering to the subject niclosamide compounds (or pharmaceutically acceptable salts and/or co-crystals thereof, e.g., niclosamide). In some embodiments, the niclosamide compounds have one or more properties that include, but are not limited to: a particular purity (e.g., a chemical purity of greater than about 99.0%) or a particular particle size (e.g., a particular particle size distribution and/or a particular particle size range and/or a specific surface area range). In an aspect, the niclosamide compounds described herein (e.g., niclosamide) can form part of compositions, dosage forms (e.g., unit dosage forms), and the like, which are suitable for respiratory administration (e.g., via inhalation and/or intranasally). In another aspect, the niclosamide compounds described herein (e.g.
Abstract: The present disclosure describes methods of treating lymphoma that expresses a short histone H2A variant. In some embodiments, the method can comprise collecting a sample from a subject having or suspected of having lymphoma, detecting a short histone H2A variant (sH2A) expression level in the sample collected from the subject, and administering to the subject a therapeutically effective dose of an anthracycline agent, if the subject has sH2A variant expression level that is detectable. In other embodiments, the sH2A is the H2A.B variant. In other embodiments, the anthracycline agent can be aclarubicin.
Type:
Grant
Filed:
November 1, 2021
Date of Patent:
September 5, 2023
Assignee:
Fred Hutchinson Cancer Center
Inventors:
Jay Francis Sarthy, Antoine Molaro, Marie Bleakley, Guo-Liang Chew
Abstract: Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
August 29, 2023
Assignee:
Dantari, Inc.
Inventors:
Emily A. Wyent, Carl M. Blumenfeld, Robert J. Lamm
Abstract: A method of treating cancer in an individual includes a step of administering to the individual a pharmaceutically effective amount of (a) a first active agent adapted for producing secretion of prostate apoptosis response-4 (Par-4) from normal cells and (b) a second active agent adapted for elevating GRP78 receptors for Par-4 on a surface of a cancer cell in the individual.
Type:
Grant
Filed:
February 17, 2021
Date of Patent:
August 22, 2023
Assignee:
University of Kentucky Research Foundation
Inventors:
Vivek M. Rangnekar, Ravshan Burikhanov, David S. Watt
Abstract: A halosilane compound: R1CH2CH2SiR52X is prepared by hydrosilylation reaction of a vinyl compound: R1CH?CH2 with a halogenodiorganosilane compound having formula: HSiR52X in the co-presence of an iridium catalyst, an internal olefin compound, and an allyl halide. The halosilane compound is prepared on an industrial scale with the advantages of low costs, high yields, and high selectivity, using a small amount of iridium catalyst.
Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
Abstract: Provided are methods and compositions for negatively and positively selecting for different size nucleic acid (e.g., DNA or RNA) fragments on borosilicate glass fiber membranes, silica and metal oxide surfaces such that only those fragments falling within a desired size range are obtained.
Type:
Grant
Filed:
November 20, 2020
Date of Patent:
August 15, 2023
Assignee:
QIAGEN Sciences, LLC
Inventors:
Vince Moroney, Eddie Adams, Mark Brolaski, Ingemar Pedron
Abstract: The present invention relates to certain cortexolone derivatives of formula (I) and the use of the same as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. The present invention also relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of the pharmaceutical compositions as antitumor medicinal products.
Abstract: Methods for treating or inhibiting cancer and/or one or more related conditions by administering to a subject in need thereof an effective amount of a compound of Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of any of the foregoing. For example, methods for treating AML, MDS, neutropenia, and/or mucositis comprising administering a pharmaceutical composition comprising a compound of Formula (I) are described.
Type:
Grant
Filed:
March 4, 2019
Date of Patent:
July 25, 2023
Assignee:
GlycoMimetics, Inc.
Inventors:
Helen M. Thackray, Henry H. Flanner, Curt D. Wolfgang
Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
Type:
Grant
Filed:
September 14, 2021
Date of Patent:
July 25, 2023
Assignee:
RADIUS PHARMACEUTICALS, INC.
Inventors:
Michael Paul Cruskie, Jr., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
Abstract: Novel N-alkyl substituted perhydridocyclic silazanes, oligomeric N-alkyl perhydridosilazane compounds, and N-alkylaminodihydridohalosilanes, and a method for their synthesis are provided. The novel compounds may be used to form high silicon nitride content films by thermal or plasma induced decomposition.
Type:
Grant
Filed:
March 24, 2021
Date of Patent:
July 18, 2023
Assignee:
GELEST, INC.
Inventors:
Barry C. Arkles, Youlin Pan, Fernando Jove