Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

Abstract: System and method of ultrasound imaging methodology are provided. The system and method can include directing an array to transmit sets of cascaded titled ultrasound waves towards a tissue sample, decoding reflected signals through summing, subtracting, and delay operations. The reflected signals can be reconstructed to provide a final decoded output.

Abstract: A method includes, in a medical procedure carried out during a time interval including at least first and second time periods, receiving, for the first time period, a first electrical signal indicative of at least a first position and a first orientation of a hand-held device directing energy to one or more volumetric portions of an organ. A second electrical signal indicative of at least a second position and a second orientation of the hand-held device is received for the second time period. Based on the first and second electrical signals, a cumulative energy applied to at least one of the one or more volumetric portions is estimated. The estimated cumulative energy, of at least one of the one or more volumetric portions, is overlaid on an anatomical image of the organ.

Abstract: A system including: a table assembly for supporting a subject in one or more examination positions; a table support assembly for supporting the table assembly, wherein the table support assembly includes: one or more moving mechanisms controlled to move the table assembly relative to a reference point along one or more axes, and to rotate the table assembly around the one or more axes; and a probe support assembly comprising: a grip for holding a probe; and an arrangement of a plurality of arms and joints controlled to movably support the probe that is held by the grip, wherein the probe support assembly is removably arranged at a predetermined position and orientation relative to the table support assembly to permit movement of the table support assembly and the probe support assembly for reproduction of a position and orientation of the probe relative to the subject supported by the table assembly.

Abstract: A scintillation block detector employs an array of optically air coupled scintillation pixels, the array being wrapped in reflector material and optically coupled to an array of silicon photomultiplier light sensors with common-cathode signal timing pickoff and individual anode signal position and energy determination. The design features afford an optimized combination of photopeak energy event sensitivity and timing, while reducing electronic circuit complexity and power requirements, and easing necessary fabrication methods. Four of these small blocks, or “miniblocks,” can be combined as optically and electrically separated quadrants of a larger single detector in order to recover detection efficiency that would otherwise be lost due to scattering between them.

Abstract: A system and method is provided for acquiring flow encoded data from a subject using a magnetic resonance imaging (MRI) system. The method includes acquiring flow encoded (FE) data with alternating encoding polarities and along two of three orthogonal directions through the subject over at least two cycles of the flow within the subject; and separating the FE data into directional FE datasets using a temporal filter that separates the FE data based on temporal modulation of the FE directions caused by the alternating encoding polarities extending over the at least two cycles of the flow within the subject that shift the Fourier spectrum of velocity waveforms corresponding to the FE data. The method also includes using the directional FE datasets to generate an image of the subject showing flow within the subject caused by the at least two cycles of flow within the subject.

Abstract: Methods for reducing electromagnetic interference arising from use of multiple ultrasound transducers in an array, particularly inside a human body that is inside a magnetic resonance imaging device. Electrical signals driving the transducers are offset in phase with respect to one another so as to achieve maximum offset of electrical and magnetic fields arising from such signals and transducers. Phase offsets are dynamically adjusted to respond to changes in driving amplitudes and frequencies so as to maintain optimal reduction of electromagnetic interference.

Abstract: A radiographic imaging apparatus includes an image processor configured to perform image processing on a radiation image generated by an image generator, and a display configured to display a processed image that has been subjected to the image processing in the image processor. The image processor is configured to perform control to create the processed image showing an expanded portion in which a balloon introduced into a subject is expanded.

Abstract: Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.

Abstract: A method for selecting a medical device for use in the performance of a medical procedure. The method comprises acquiring image data relating to an anatomical region of interest of a patient's body and generating a multi-dimensional depiction of the anatomical region of interest using the acquired image data. The method further comprises defining a plurality of points relative to the multi-dimensional depiction, determining one or more measurements based on the defined plurality of points, and then selecting a medical device to be used based on the determined measurements.

Abstract: A marker delivery device includes a handle having a housing, and a cannula positioned in the handle that retractably extends beyond the front end of the housing. A retraction mechanism is mounted to the housing, and has a shear member. The retraction mechanism is coupled to a proximal end of the cannula. The retraction mechanism is configured to store a retraction force, and is configured to facilitate a retraction of the cannula into a chamber of the housing upon an actuation of the retraction mechanism. The shear member has a shear region of reduced cross section dimension. The shear member is configured to be displaced upon the actuation of the retraction mechanism to expose the shear region to the retraction force to shear the shear member at the shear region to enable the retraction and prevent reuse of the marker delivery device.

Abstract: Periodic displacement occurs in body tissue due to heartbeat. A peak level D of the movement distance of the body tissue is detected (Step 21), and a heartbeat cycle T is calculated from a frequency spectrum (Steps 22 and 23). By dividing twice the peak level D by the heartbeat cycle T, the moving velocity of the body tissue in a unit heartbeat cycle is calculated (Step 24). By dividing the moving velocity by a frame rate r, an average movement distance of the body tissue between frames is calculated (Step 25). In a case where the average movement distance is smaller than a predetermined threshold value, a time interval between the frames used for the calculation of the movement distance is extended (being Step 26 NO, Step 27).

Abstract: Ultrasound image devices, systems, and methods are provided. In one embodiment, an ultrasound device includes a first ultrasound component (210) configured to generate a first signal representative of a subject's anatomy along a first axis; a second ultrasound component (220) configured to generate a second signal representative of the subject's anatomy along a second axis, the first axis disposed at an angle with respect to the second axis; and a processing component (420) in communication with the first ultrasound component and the second ultrasound component, the processing component configured to determine an orientation of the ultrasound device with respect to the subject's anatomy based on the first signal and the second signal.

Abstract: Various embodiments of an apparatus, methods, systems and computer program products described herein are directed to Field Visualization Engine. The Field Visualization Engine tracks one or more collimator poses relative to one or more Augmented Reality (AR) headset device poses. Each respective collimator pose and each respective headset device pose corresponds to a three-dimensional (3D) unified coordinate space (“3D space”). The Field Visualization Engine generates an AR representation of a beam emanating from the collimator based at least on a current collimator pose and a current headset device pose. The Field Visualization Engine further generates an AR visualization of emanation of the beam throughout an AR display of medical data.

Abstract: Described herein are systems and methods for spectral unmixing of in vivo light data. The spectral unmixing separates image data according to spectra from multiple internal light sources in an effort to isolate one or more spectrum of interest. The spectral unmixing obtains images with a combination of different and known excitation and emission limits. The spectral unmixing then uses an iterative solution process to separate spectra for the multiple fluorescent light sources, and provides a spectrum and/or a spatial distribution map for at least one of the internal light sources.

Abstract: Provided is an ultrasound imaging apparatus including: an ultrasound probe including a transducer module including an ultrasound transducer array, a driving device configured to rotate the transducer module, a magnet configured to rotate as a result of rotation of the transducer module, and a position sensor configured to output one of a first signal and a second signal on the basis of a change in magnetic flux density according to rotation of the magnet; and a controller configured to determine a first time for which the first signal is output as the transducer module rotates in a first direction, control the driving device to switch the rotating direction of the transduce module from the first direction to a second direction at a first switching time point at which an output signal is switched from the first signal to the second signal, control the driving device to switch the rotating direction of the transducer module one or more times during a time corresponding to the first time with respect to a second

Abstract: Disclosed are methods of using planar acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of flat piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a modulated planar acoustic wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Abstract: Accordion to one embodiment, an ultrasound diagnosis apparatus includes a volume data generating unit, an image generating unit, an MPR image generating unit, and a display controller. The volume data generating unit generates, based on position angle information of an ultrasound probe and echo data from the ultrasound probe, functional volume data of a subject accompanied with the position angle information. The image generating unit sequentially generates a sectional image of the subject based on the position angle information and the echo data. The MPR image generating unit generates an MPR image corresponding to the cross-section of the sectional image from the functional volume data based on the position angle information corresponding to the sectional image and the position angle information attached to the functional volume data. The display controller displays the sectional image and the MPR image in parallel or in a superimposed manner on a display.

Abstract: A system and related methods for performing nerve detection during surgical access using ultrasound testing during surgery.

Abstract: A hand-held probe for measuring radiation or magnetic activity includes a probe having a handle having a longitudinal axis and a shaft portion adapted to be inserted or held above a radiation or magnetic emitting source implanted within a patient's body or tissue of interest, the shaft portion includes a radiation or magnetic activity sensor configured to detect and measure radiation emitted from the radiation emitting source or magnetic activity from a magnetic source; the radiation emitting source being an implanted seed or a radioisotope that is injected near a tumor site in the patient's body; the probe including a signal processing device for further processing the measured radiation or magnetic activity; and a communication medium to exchange data from the hand-held probe with an external data processor unit.