Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of the cavity in the end of the bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the channel by an adhesive. The stem of the prosthesis beyond the channel may be cemented or uncemented. The support structure may have an approximately funnel shape. The support structure may be a hollow porous cylindrical sleeve. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining a channel between the pair of components. The support structure may comprise a plurality of pedestals secured to the inner surface of the cavity of the bone.

Abstract: A ureteral stent includes an elongated member, which has a tubular shape, and a distal retention structure. The elongated member includes a sidewall that defines a lumen and has a spiral-shaped opening with at least two rotations. The sidewall has an inner surface and an outer surface. The sidewall between the inner surface and the outer surface is devoid of another lumen. The elongated member is configured to move between a retracted configuration and an expanded configuration along a longitudinal axis of the lumen. The distal retention structure is disposed at a distal end of the elongated member for retention in a kidney. The distal retention structure defines a lumen in fluid communication with the lumen defined by the sidewall of the elongated member.

Abstract: A method of preventing capsular opacification and fibrosis after cataract extraction and and/or preventing fibrosis around a shunt or stent after glaucoma surgery is disclosed herein. In the cataract procedure, after the cortex and nucleus of the natural lens with the cataract has been removed, a photosensitizer is applied inside the lens capsule, a posterior portion of the lens capsule is irradiated so as to activate cross-linkers and prevent capsular opacification and fibrosis, and an intraocular lens is inserted into the lens capsule. In the glaucoma procedure, a fluid drainage opening is formed and/or a stent is inserted into the eye, a photosensitizer is applied inside an anterior chamber of the eye so that a diffused stream of the photosensitizer travels through the fluid drainage opening or the stent, and the tissue surrounding the fluid drainage opening or the stent is irradiated so as to activate cross-linkers and prevent fibrosis.

Abstract: A prosthetic heart valve has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. A support frame including three cusp positioners is fixed with respect to a leaflet frame and located intermediate each pair of adjacent commissure regions. The valve is desirably compressible. In the aortic valve position, the cusp positioners angle outward into contact with the sinus cavities, and compress the native leaflets if they are not excised, or the aortic wall if they are.

Abstract: A surgical implant device, comprising: a body portion defining a plurality of ports; a plurality of bone screws disposed partially through the plurality of ports defined by the body portion; a locking plate disposed over a head portion of at least one of the plurality of bone screws and engaging a plurality of recesses manufactured into a side of the body portion; and a screw operable for compressing the locking plate against the side of the body portion. Optionally, the surgical implant device further comprising: one or more surfaces comprising a plurality of protruding structures; wherein the body portion and the one or more surfaces comprising the plurality of protruding structures are integrally formed. The one or more surfaces comprising the plurality of protruding structures are formed by an additive manufacturing process.

Abstract: The present invention relates to a transcatheter method for providing fluid communication between two anatomical compartments. The present invention also relates to a transcatheter system comprising an intracorporeal connector for fluid communication between two anatomical compartments through at least one anatomical wall, wherein said connector is adapted to receive a flow regulating device, a connector, a flow regulating device and an insertion device.

Abstract: An endoprosthesis includes an expandable tubular framework having a first end, a second end, and a lumen extending therethrough along a longitudinal axis. The expandable tubular framework includes a plurality of interconnected struts. The interconnected struts include a radially outward face which includes a plurality of anti-migration grooves defining anti-migration teeth formed therebetween. The anti-migration teeth are configured to engage tissue to resist migration of the endoprosthesis within a body lumen.

Abstract: In some examples an implantable medical device may include a frame and a flexible tubular valve body. The frame may define a frame lumen and may be expandable from a compressed configuration to an expanded configuration. The flexible tubular valve body may extend between a downstream end and an upstream end. The valve body may define a valve lumen, a downstream opening at the downstream end, and an upstream opening at the upstream end. The valve body may be attached to the frame such that the frame lumen is in fluid communication with the valve lumen. The valve body may comprise a neck and may be configured to fold about the neck to at least partially close the valve lumen. The valve body may be configured to collapse in an absence of fluid flow through the valve lumen to at least partially close the valve lumen.

Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of a cavity of a bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the support structure by an adhesive. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining the channel between the pair of components.

Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of a cavity of a bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the support structure by an adhesive. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining the channel between the pair of components.

Abstract: A femoral augment, or set of augments, for use with a knee joint prosthesis, where the femoral augment includes a main body portion, an aperture formed within the main body portion and extending in a generally distal/proximal direction, and a pair of legs extending outwardly from said main body portion in a generally posterior direction. In the preferred embodiment, the aperture is configured to receive a stem extension implant, and to allow it to pass through. Additionally, the legs of the femoral augment are preferably configured to be seated proximal of a proximal side of a pair of condylar portions of a femoral component of a knee joint prosthesis.

Abstract: An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented.

Abstract: Provided are a stent to be placed in the bile duct and a process for producing the stent, the stent hollow being less apt to be blocked even when the stent is placed in the bile duct for a long period. The inner peripheral surface of the stent is coated with a resin layer with resistance to sludge formation that includes a polymer obtained by polymerizing 2-methoxyethyl acrylate. This stent is produced by applying a coating fluid that contains 0.1-0.5 mass % polymer obtained by polymerizing 2-methoxyethyl acrylate, to the inner peripheral surface of a stent.

Abstract: An implantable intracardiac device to prevent systolic anterior motion of the anterior mitral valve leaflet into the left ventricular outflow tract is described. The device comprises a blocking member configured for implantation within the left ventricle of the heart and in-situ blocking of systolic anterior motion of the mitral valve into the left ventricular outflow tract when anchored into the left ventricle of the heart. The device may be configured for radial expansion from a contracted orientation suitable for transluminal delivery to the left ventricle of the heart within a suitable delivery vehicle and an expanded orientation suitable for deployment within the left ventricle of the heart. The device comprises anchors configured for anchoring the device in-situ within the left ventricle to a wall of the left ventricle.

Abstract: An endoluminal prosthesis for placement within a body vessel may include a tubular support structure including a proximal end segment, a distal end segment, an intermediate segment positioned between the proximal end segment and the distal end segment, a lumen extending longitudinally within the support structure, a luminal surface, and an abluminal surface opposite the luminal surface. The prosthesis may include a first layer of nonwoven electrospun fibers positioned on the luminal surface of the support structure. The prosthesis may include a second layer of nonwoven electrospun fibers positioned on the abluminal surface of the support structure. At least one of the proximal end segment or the distal end segment of the support structure may be encapsulated within a covering including the first layer of nonwoven electrospun fibers and the second layer of nonwoven electrospun fibers. The intermediate segment of the support structure may be unencapsulated within the covering.

Abstract: An imaging lens structure and method of imaging are presented. The imaging lens structure comprising a lens region defining an effective aperture of the lens structure. The lens region comprises an arrangement of lens zones distributed within the lens region and comprising zones of at least two different optical functions differently affecting light passing therethrough. The zones of at least two different optical functions are arranged in an interlaced fashion along said lens region corresponding to a surface relief of the lens region such that adjacent lens zones of different optical functions are spaced apart from one another along an optical axis of the lens structure a distance larger than a coherence length of light at least one spectral range for which said lens structure is designed.

Abstract: Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device configured in accordance with embodiments of the present technology can include an anchoring member coupled to a flexible, compliant damping member including a generally tubular sidewall having an outer surface, an inner surface defining a lumen configured to direct blood flow, a first end portion and a second end portion, and a damping region between the first and second end portions. The inner and outer surfaces of the damping member can be spaced apart by a distance greater at the damping region than at the first or second end portions. When blood flows through the damping member during systole, the damping member absorbs a portion of the pulsatile energy of the blood, thereby reducing a magnitude of the pulse pressure transmitted to a portion of the blood vessel distal to the damping device.

Abstract: Contact lenses incorporate multifocal power profiles that at least one of slow, retard or preventing myopia progression. The lens includes a first zone at a center of the ophthalmic lens and at least one peripheral zone surrounding the first zone. The at least one peripheral zone has a different width and dioptric power than the first zone. The first zone and at least one peripheral zone are stepped or discontinuous. The multifocal power profile has substantially equivalent foveal vision correction to a single vision lens and has a depth of focus and reduced retinal image quality sensitivity that slows, retards, or prevents myopia progression.

Abstract: Methods of adjusting an intraocular lens after implantation. In some embodiments the methods include positioning an accommodating intraocular lens within an eye, the intraocular lens comprising an optic portion in fluid communication with a peripheral chamber, wherein movement of a fluid between the peripheral chamber and the optic portion in response to ciliary muscle movement changes the optical power of the lens, and reducing a power of the intraocular lens by causing the fluid to move between the optic portion and the peripheral chamber, wherein the reduction in power of the intraocular lens is not in response to ciliary muscle movement, and wherein the positioning step occurs prior to reducing the power.

Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the frame attached thereto. The frame may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes an integrated handle shaft and balloon catheter. A valve holder is stored with the heart valve and the handle shaft easily attaches thereto to improve valve preparation steps.