Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
Type:
Grant
Filed:
April 24, 2015
Date of Patent:
September 12, 2017
Assignee:
GEORGETOWN UNIVERSITY
Inventors:
Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong