Patents Examined by Peter Tung
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Patent number: 6391605Abstract: A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.Type: GrantFiled: March 19, 1998Date of Patent: May 21, 2002Assignee: Roche Vitamins Inc.Inventors: Dirk Kostrewa, Luis Pasamontes, Andrea Tomschy, Adolphus van Loon, Kurt Vogel, Markus Wyss
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Patent number: 6352847Abstract: The invention provides an ammonia elimination reagent in solution, comprising a thermo-resistant isocitrate dehydrogenase with prominent stability under conditions at high alkaline pHs. For example, the isocitrate dehydrogenase is preferably derived from the genus Thermus. For an assay system of biological substances generating a reaction product ammonia, an ammonia elimination reagent can be prepared by selecting and using the enzyme; the resulting ammonia elimination reagent can be stored in solution; additionally, the assay system can be designed in combination with both the coenzymes NAD+ and NADP+. The ammonia elimination reagent is novel and can eliminate ammonia in an extremely short time.Type: GrantFiled: June 8, 1999Date of Patent: March 5, 2002Assignee: Japan as represented by Director General of Agency of Industrial Science and TechnologyInventors: Hirokazu Matsukawa, Osamu Oka, Tuyosi Fujita, Kentaro Miyazaki
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Patent number: 6306630Abstract: The present invention relates to Aspergillus porphobilinogen synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the porphobilinogen synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the porphobilinogen synthases.Type: GrantFiled: September 30, 1998Date of Patent: October 23, 2001Assignee: Novozymes Biotech, Inc.Inventors: Aubrey Jones, Joel R. Cherry
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Patent number: 6274361Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.Type: GrantFiled: May 18, 1998Date of Patent: August 14, 2001Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Sanjoy Biswas, Martin K. R. Burnham, Andrew P. Fosberry, John E Hodgson, Elizabeth J Lawlor, Tong Li, Damien McDevitt, Christopher Michael Traini, Martin Rosenberg, Judith Ward, Richard Lloyd Warren, Magdalena Zalacain
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Patent number: 6239258Abstract: The present invention features a human Nkx-2.2 polypeptide and nucleotide sequences encoding Nkx-2.2 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In addition, the invention features polynucleotide sequences that hybridize under stringent conditions to SEQ ID NO:1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human Nkx-2.2 polypeptide. The present invention also relates to antibodies that bind specifically to a human Nkx-2.2 polypeptide, and methods for producing human Nkx-2.2 polypeptides.Type: GrantFiled: January 20, 1998Date of Patent: May 29, 2001Assignees: The Regents of the University of California, Arch Development Corp.Inventors: Michael S. German, Graeme I. Bell, Hiroto Furuta, Lori Sussel
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Patent number: 6197558Abstract: A process for making natural and unnatural amino acids which comprises reacting a first amino acid, a keto acid and a transaminase enzyme under conditions appropriate to produce a second amino acid and pyruvate; reacting the pyruvate with acetolactate synthase under conditions appropriate to produce a compound that does not react with the transaminase enzyme and separating the second amino acid.Type: GrantFiled: May 19, 1997Date of Patent: March 6, 2001Assignee: NSC TechnologiesInventor: Ian G. Fotheringham
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Patent number: 6183740Abstract: A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity (SEQ ID NO:2). The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.Type: GrantFiled: May 25, 1999Date of Patent: February 6, 2001Assignee: Diversa CorporationInventors: Jay M. Short, Keith A. Kretz
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Patent number: 5958731Abstract: The invention provides a human cell junction PDZ protein (CJPDZ) and polynucleotides which identify and encode CJPDZ. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CJPDZ.Type: GrantFiled: September 11, 1998Date of Patent: September 28, 1999Assignee: Incyte Pharmaceuticals, Inc.Inventors: Henry Yue, Janice Au-Young, Chandra Patterson