Abstract: Hydro-activated and/or oxygen activated aqueous, enzymatic, antimicrobial dentifrices are stabilized against enzymatic activation prior to oral application of the dentifrice by incorporating a thickener into the dentifrice formulation so as to provide the formulation with an enzyme immobilizing viscosity which inhibits enzymatic action during processing and in the dentifrice package. An illustrative, thickened, enzymatic dentifrice with this enhancement contains glucose oxidase, glucose, lactoperoxidase and potassium thiocyanate together with carboxymethylcellulose in an amount to provide the dentifrice with a viscosity of at least about 800 centipoises.

Abstract: A transdermal drug delivery device includes anode and cathode electrodes supported on a base member in spaced relation to each other to define a gap therebetween, a gel containing a liquid drug to be delivered covering the gap and in contact with both of the electrodes, and a liquid permeable sheet covering the gel containing the liquid to be delivered.