Abstract: Disclosed herein are systems and methods for nerve conduction block that can involve the delivery of relatively high amounts of charge safely to tissue. Such systems and methods can include control systems for safely monitoring a direct current electrode system, including delivering direct current via an electrode lead to a target tissue of a patient; measuring the driving voltage across the electrode; comparing the driving voltage across the electrode to predetermined threshold range values; measuring the body impedance; determining a voltage drop across the lead from the body impedance measurement; and adjusting the driving voltage to maintain the voltage drop across the lead within a predetermined voltage range.

Abstract: A patient monitoring sensor having a communication interface, through which the patient monitoring sensor can communicate with a monitor is provided. The patient monitoring sensor includes a light-emitting diode (LED) communicatively coupled to the communication interface and a detector, communicatively coupled to the communication interface, capable of detecting light. The patient monitoring sensor also includes a faraday cage disposed around the detector, wherein the faraday cage includes an aperture configured to limit an amount of light from the LED that the detector is able to detect.

Abstract: Approaches for portably and discreetly treating muscle cramping using one or more of a selectively controllable transcutaneous electrical nerve stimulation (TENS) unit and a heating element comprising resistive fabric. Cramping of the muscle may be detected with a surface electromyography (sEMG) unit. Artificial intelligence techniques may be applied using the sEMG signals and/or user input to identify effective treatment settings.

Abstract: A system for neurorehabilitation is disclosed that includes a motion detector configured to generate a motion detection feedback signal, a transcutaneous auricular vagus nerve stimulation module, and a controller configured to receive the motion detection feedback signal and send a stimulation signal to the transcutaneous auricular vagus nerve stimulation module based on the motion detection feedback signal meeting a minimum threshold criteria. A method for neurorehabilitation is disclosed that includes the steps of detecting patient motor activity, determining if the detected patient motor activity meets a minimum threshold criteria, and stimulating a vagus nerve through transcutaneous auricular vagus nerve stimulation if the minimum threshold criteria is met.

Abstract: Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and/or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and/or the motion data, thereby improving patient compliance with a prescribed therapy regimen.

Abstract: An apparatus and method for treating obstructive sleep apnea includes a pulse oximeter, a source of transcutaneous electrical stimulation having a pair of electrodes for delivering TES to a person, and a controller. The electrodes are adapted to be applied to the person's skin adjacent the person's upper airway to stimulate one or more nerves or muscles in the upper airway when TES is applied to the electrodes. The controller is adapted to receive blood oxygen data from the pulse oximeter and is programmed to apply TES when the blood oxygen indicates that the person's blood oxygen is below a predetermined threshold, so as to increase a resting tone of the person's tongue.

Abstract: A pacemaker having a motion sensor delivers atrial-synchronized ventricular pacing by detecting events from a signal produced by the motion sensor and delivering ventricular pacing pulses at a rate that tracks the rate of the detected events. The pacemaker is configured to confirm atrial tracking of the ventricular pacing pulses by determining if detected events from the motion sensor signal are atrial events. The pacemaker is configured to adjust a control parameter used for detecting events from the motion sensor signal if atrial tracking is not confirmed.

Abstract: Real time mirroring of dominant brain frequencies through the use of two types of stimuli is provided. Through devices and methods that simultaneously look for asymmetries and in real time, one can create real time variable sequences of acoustic and electric stimuli, and then one can effectively and efficiently support the brain to balance its activity between corresponding right and left lobes without one's mindful attention.

Abstract: A lens or eye mask for treating an eye of a patient includes a flexible printed circuit board (PCB) that is configured to fit over at least a portion of a surface of the eye and a plurality of electrode pairs that are arranged on the flexible PCB. An electrical source is configured to provide electrical energy to each electrode pair to create a near electromagnetic field within the eye and thereby therapeutically treat target tissue within the eye. A spacing between electrodes of each electrode pair is controlled to achieve a predetermined penetration depth of the near electromagnetic field within the eye.

Abstract: This disclosure describes methods, systems, and devices configured to determine a timing of a future bladder related event of a patient. For example, a system includes processing circuitry configured to identify a timing of a plurality of bladder related events of a patient, determine, based on the timing of the plurality of bladder related events of the patient, a probability to experience a bladder related event function for the patient, the probability to experience a bladder related event function indicating a probability that the patient will experience a bladder related event at an elapsed time after a previous bladder related event, predict, based on the probability to experience a bladder related event function, a timing of a future bladder related event, and control delivery of a therapy to the patient based on the predicted timing of the future bladder related event.

Abstract: A power supply apparatus includes a power supply configured to apply an alternating current to a magnetic field generation apparatus; and a controller configured to control the alternating current applied by the power supply. The controller controls the power supply to apply the alternating current having a waveform pattern including a plurality of current waveforms having different frequency spectrums from each other.

Abstract: Provided is a method for predicting a PTSD diagnosis in a patient comprising receiving audio input data from a patient; determining one or more audio input indicators based on the audio input data, wherein each audio input indicator of the one or more audio input indicators represents a likelihood of a positive PTSD diagnosis based on the audio input data; receiving clinical assessment data from the patient; determining one or more clinical assessment indicators based on the clinical assessment data, wherein each clinical assessment indicator of the one or more clinical assessment indicators represents a likelihood of a positive PTSD diagnosis based on the clinical assessment data; combining the one or more audio input indicators and the one or more clinical assessment indicators using a prediction model chosen by a clinician; and determining a PTSD diagnosis in the patient based on the audio input data and the clinical assessment data.

Abstract: Methods and apparatus for increasing cerebral blood flow for improving the flow of blood to the brain during and/or following an ischaemic stroke. The apparatus includes a plurality of inflatable cuffs to be positioned, in use, around a respective limb of a patient. Once inflated, the cuffs exert a pressure upon the limb to reduce blood flow to the limb below the point at which the cuff is positioned. Reducing blood flow to the limbs causes an increase in blood flow to the brain, and will therefore improve stroke outcomes. The apparatus includes a control module for controlling inflation and deflation of each cuff. The control module detects, measures and monitors cerebral blood flow and uses these measurements to control inflation and deflation of each cuff such that cerebral blood flow is maintained above a baseline level during treatment of the patient.

Abstract: A signal processing apparatus includes a memory, and a processor coupled to the memory and configured to perform a process including obtaining measurement data including a signal of interest and an interference signal generated in proximity to a signal source of the signal of interest, estimating a signal source in an extraction target area including the signal source of the signal of interest and a signal source of the interference signal based on the measurement data, selecting the signal source of the interference signal based on a result of the estimating a signal source and extracting interference signal data generated from the selected signal source of the interference signal, and extracting the signal of interest by removing a common part between the measurement data and the interference signal data.

Abstract: A system, device, and method for transcutaneous nerve stimulation such as facial nerve stimulation, and in particular, to using transcutaneous nerve stimulation for artificially eliciting eye blink, such as with humans with acute facial paralysis (Bell's palsy or Dry Eye syndrome), is disclosed. A battery-operated wearable device may employ a pulse generator for periodically and automatically generating bursts train of asymmetrical Bi-Phasic square pulses. The output pulses are fed to two electrodes that are attached to the skin of the treated person to stimulate the facial nerve for eliciting blinking at a rate that mimics normal blinking operation. The device may include a sensor and a wireless connection, and the parameters of, or the activation of, the generated bursts may be controlled by the sensor output, by human user control, or by data received from the wireless network. Further, the device may transmit status to the wireless network.

Abstract: Methods, devices and systems to improve neural stimulation by applying biphasic waveforms including a positive anodal pulse followed by a negative cathodal pulse to speed conduction and improve mitochondrial function in conditions such as cerebellar dysfunction (such as gluten ataxia, spinocerebellar ataxia, and Alzheimer's disease). Improved neural stimulation of more distal brain structures may interrupt epileptic seizures. Additionally, biphasic waveforms including a positive anodal pulse followed by a negative cathodal pulse speed wound healing by lowering the cell membrane potential of the skin, and may stimulate the release of hormonal secretions or insulin by proper placement of electrodes.

Abstract: An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

Abstract: A control system for a movement reconstruction and/or restoration system for a patient, comprising at least one sensor, at least one controller, at least one programmer, at least one stimulation system, wherein the controller is connected with the sensor, the programmer and the stimulation system, wherein the sensor is part of or attached to a training entity in order to create and/or guide a movement model for a patient and/or adjust stimulation settings based on sensor input.

Abstract: A nerve stimulating apparatus includes a plurality of stimulating units configured to respectively apply stimuli to a plurality of nerve regions branching from a particular nerve region of a living body, and a stimulation timing controller configured to set generating timings of respectively generating the stimuli at the plurality of stimulating units. The stimulation timing controller sets the generating timings of generating the stimuli at the plurality of stimulating units based on response results of the particular nerve region, the response results being obtained in response to the stimuli that are respectively generated at the plurality of stimulating units and that are respectively applied to the plurality of nerve regions, and the response results being measured by a biometric information measuring apparatus that measures biometric information.

Abstract: A peripheral device for regulating neural correlates of arousal and emotion regulation to be worn or held against the body is disclosed. The device can be triggered by either physiological signs or manual intervention and produces cutaneous signals such as vibration or electricity using novel combinations of physiologically reactive frequencies without effort on the part of the user. One embodiment includes combining sensors that measure changes in physiological signals of stress such as speech rate and pitch, galvanic skin response, or heart rate variability, and, using a machine learning algorithm on personalized data, can determine whether these changes are likely to benefit from regulation. If they are outside an idiosyncratic predetermined range, the device produces stimulation and the person will feel regulated if they are touching/wearing the device, or can choose to use the device if it is not currently being touched or worn.