Abstract: The present invention provides a rotating machinery diagnosis and monitoring device and method which have high reliability and enable the grasping of a symptom trend of vibrations and a determination of progress of the vibrations during increase and decrease in the rotation speed of a rotor. A rotating machinery diagnosis and monitoring device of the present invention, comprising: an input section that receives vibration values and rotation speeds as operation data of a rotating machine; a computing section that performs computations using the operation data received; and a calculator that includes an output section. The computing section is configured to identify peak values of the vibration values and evaluate each of magnitude of the peak values and the rotation speeds at the peak values. The output section is configured to display externally a result of evaluations performed by the computing section.

Abstract: A data test method, an electronic device, and a storage medium are provided. In the data test method, based on a Density-Based Spatial Clustering of Applications with Noise (DBSCAN), at least one cluster is obtained by removing discrete points in the target data and performing clustering, an calculation result is obtained by performing a regression analysis on the target data with the objective function, and parameters to be tested are verified according to the calculation result. Utilizing the data test method, objective function can be used to perform verification and residual analysis on the target data, related descriptions are be repeated here.

Abstract: A system and method for determining whether a battery is operating in an anomalous condition can include or be configured to measure sensor data, estimate a local property of the battery using on the sensor data, and classify whether the battery is operating in the anomalous condition based on the local property.

Abstract: An instrument panel includes a frame defining an opening, a plurality of cards, and an HMI. The cards have a front face, a rear face, one or more circuits, and a data interface on the rear face in communication with the circuits. The cards include one or more first cards and one or more second cards. The first cards front face have a vertical dimension approximately equal to a vertical dimension of the opening. The second cards have a body, a nose projecting from the body defining the second cards front face, and a recess between the nose and body. The HMI includes a front face received within the opening. The first cards are positioned with the front face visible within the opening. The second cards are positioned with the nose visible within the opening and a depth of the HMI received within the recess.

Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: System and methods are provided for empirical analysis of remaining life in electromechanical devices. Sensors are positioned to generate signals representing sound energy emitted by devices, and digital sound data are stored corresponding thereto. The system classifies sound characteristics and their corresponding impact on wear rate over time via recurring analysis of the stored sound data. For a selected device, a wear state is estimated based on a comparison of current sound energy emitted therefrom with respect to sound data for a comparable group of electromechanical devices, and it may be ascertained whether certain classified sound characteristics are present in digital sound data corresponding to the selected electromechanical device. Output signals are selectively generated based on the estimated wear state and/or classified sound characteristics ascertained to be present, e.g.

Abstract: The present invention relates to an anti-VAMP2 antibody that inhibits SNARE complex and uses thereof, and more specifically, the present invention relates to an anti-VAMP2 antibody or antigen-binding fragments thereof comprising heavy and light chain CDRs of a specific sequence. The anti-VAMP2 antibody is expected to be useful for improving or treating skin wrinkles by inhibiting SNARE complex formation.

Abstract: Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.

Abstract: A method for locating buried utilities in a utility locator is disclosed. The method may include receiving, at an antenna array for receiving magnetic field signals, a plurality of magnetic field signals at predefined signal frequencies in a predefined frequency suite, generating, in a receiver coupled to an output of the antenna array, a first receiver output signal, generating, in a processing element coupled to the receiver, a first set of data associated with the two or more signal components, and storing, in a non-transitory memory of the locator, the first set of data.

Abstract: Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.

Abstract: An accuracy diagnostic device includes a change amount detecting unit, a change amount recording unit, an accuracy change predictor, and an accuracy adjustment timing presenting unit. The change amount detecting unit detects a magnitude of a change in at least one of a state of a machine tool and a surrounding environment of the machine tool as a change amount. The change amount recording unit records the change amount. The accuracy change predictor predicts a future accuracy change of the machine tool using the change amount recorded in the change amount recording unit. The accuracy adjustment timing presenting unit presents a timing at which an accuracy adjustment is to be required for the machine tool based on the accuracy change predicted by the accuracy change predictor.

Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Abstract: System for generating maps from magnetic field utility line estimates include one or more vehicle-mounted magnetic field sensing locators, one or more antenna nodes to sense magnetic fields emitted from buried utilities, a receiver circuit to process the antenna signals, a position and orientation element to determine the position and orientation of the magnetic field sensing locating device in a world coordinate system, a processing unit to generate at one or more discrete points an estimation of one or more utility positions and orientations, and a map generation element to generate an associated map.

Abstract: Compositions and methods for minimizing antibody disulfide bond reduction are described. In one aspect, a composition is provided for culturing mammalian host cells to express an antibody including an anti-reduction agent that minimizes reduction of a disulfide bond in the antibody or fragment thereof. In some other aspects, methods for minimizing disulfide bond reduction; increasing production of an antibody or fragment thereof with intact native disulfide bonds; increasing a ratio of non-reduced to reduced antibody or fragment thereof; producing a therapeutic antibody or fragment thereof by adding a sufficient amount of an anti-reduction agent to a cell culture media, pre-harvest cell culture fluid, or harvest cell culture fluid are described. In another aspect, minimizing disulfide bond reduction in an antibody or fragment thereof culturing the host cell in a concentration of at least about 20% O2 is described.

Abstract: Compounds and compositions are disclosed in which a Drug Unit is linked to a targeting Ligand Unit through a self-stabilizing Linker Unit from which a drug compound or active drug moiety is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.

Abstract: The present invention relates to methods for separating multispecific CrossMab antibodies from light chain mispaired variants thereof in a solution comprising CrossMab bispecific antibodies and mispaired antibody variants thereof by hydrophobic interaction chromatography.

Abstract: Provided herein are methods for treating at least one symptom of ALS in a subject who has received a first dosage of BSEP inhibitor, the method including administering to the subject a composition comprising a bile acid or a pharmaceutically acceptable salt thereof and a phenylbutyrate compound, monitoring the subject for response to the B SEP inhibitor, and administering a second dosage of the BSEP inhibitor, wherein the second dosage is less than the first dosage.

Abstract: The invention provides modified heavy chain constant regions including a cysteine at position 295 by EU numbering and optionally at position 239 by EU numbering. These cysteine residues provide sites for conjugation to a drug or label. When both cysteines are present in a normal heterodimeric antibody format, there are four such sites per molecule of antibody allowing a stoichiometry of one molecule of antibody to four of drug or label. Selection of the cysteine at position 295 with or without cysteine at position 239 is advantageous over cysteines at many other positions due to ease of expression, stability and cytotoxicity.

Abstract: Provided are a system and method for monitoring tension of a track. The track tension monitoring method of determining whether tension of tracks constituting an undercarriage module, which is an undercarriage of caterpillar track equipment, is abnormal includes, when tracks are in a dynamic state, entering an abnormality determination mode for determining whether the tracks are in excessive tension or low tension, and determining, in the abnormality determination mode, whether track tension is abnormal by measuring the track tension when the tracks make a turn, when the tracks are impacted, or when the caterpillar track equipment operates.

Abstract: A system (1) for predicting anomalies of machining, in particular the anomalies generating a defect on a part machined by a machine tool, comprising: a. a signal-processing unit (10) configured to acquire raw data, in particular sensor data and machining parameters from a machine tool (2) and to process the raw data to neuromorphic-circuit input data including features extracted by the signal-processing unit; b. a neuromorphic circuit (20) connected to the signal-processing unit configured to build a neural network on an integrated circuit, wherein the neural network is trained by training data and the trained neural network enables to determine anomaly data describing anomalies of the machining in response to the neuromorphic-circuit input data, in particular to the features; and c. a controller configured to receive the determined anomaly data from the signal-processing unit and to determine at least one action, which can be taken to overcome the determined anomalies.