Patents Examined by Phynn Touzeau
  • Methods for reducing blood loss
    Patent number: 5607917
    Abstract: Blood loss in a patient undergoing surgery, particularly thoracic or abdominal surgery, is reduced by administration of factor XIII. The factor XIII may be administered in combination with aprotinin.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: March 4, 1997
    Assignee: ZymoGenetics, Inc.
    Inventors: Bruce L. A. Carter, Martin W. Edwards
  • Use of growth factor IGF-I or IGF-II
    Patent number: 5534493
    Abstract: The present invention relates to a method of treating pancreatic disorders and insufficiency by administering a medicament comprising IGF-I or IGF-II.
    Type: Grant
    Filed: February 17, 1994
    Date of Patent: July 9, 1996
    Assignee: Pharmacia AB
    Inventors: Peter D. Gluckman, David J. Mellor
  • Parathyroid hormone derivatives
    Patent number: 5434246
    Abstract: Parathyroid hormone (PTH) derivatives represented by the general formula: ##STR1## or a salt thereof, wherein R.sub.1 represents Ser or a D-.alpha.-amino acid residue of 4 or less carbon atoms;R.sub.2 represents a tetrapeptide chain which contains at least one water-soluble .alpha.-amino acid residue;R.sub.3 represents a tripeptide chain which contains at least one water-soluble .alpha.-amino acid residue; andR.sub.4 represents an aromatic amino acid residue or an amide thereof,except that R.sub.1 is Ser when R.sub.2 is His-Leu-Asn-Ser, R.sub.3 is E-F-Gwherein E is Arg or His, F is Lys or His, G is Lys, Leu or Gln, are disclosed.The parathyroid hormone derivatives of the present invention are stable and have high biological activity, therefore they are useful as drugs for bone diseases and the like.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: July 18, 1995
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tsunehiko Fukuda, Shizue Nakagawa, Shigehisa Taketomi
  • Use of human IGF-1 to treat cardiac disorders
    Patent number: 5434134
    Abstract: Human IGF-I or effective analogues thereof are used for preventing or treating cardiac disorders. Compositions are also provided that comprise human IGF-I or effective analogues thereof together with additional proteins or peptides such as other growth factors, hormones, binding proteins or receptors for enhancing or improving the desired effects of IGF-I or its effective analogues and possibly pharmaceutically acceptable carrier or diluent for the prevention or treatment of cardiac disorders.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: July 18, 1995
    Assignee: Pharmac IA AB
    Inventors: Peter Gluckman, Anna Skottner
  • Method of treating non-streptococcal bacterial infections
    Patent number: 5405832
    Abstract: A method of treating non-Streptococcal bacterial infections in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein (CRP) in a pharmaceutically-acceptable carrier. Modified-CRP has been found to be particularly effective in treating gram-negative bacterial infections and endotoxic shock.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: April 11, 1995
    Assignee: Immtech International Inc.
    Inventor: Lawrence A. Potempa
  • Injectable extended release formulations and methods
    Patent number: 5352662
    Abstract: Described is a preferred injectable, extended release formulation which includes a growth hormone or a growth hormone releasing factor in a carrier including a biocompatible hydrophobic vehicle and an amount of polyglycerol ester effective to extend release of the growth hormone or growth hormone releasing factor in an animal. Other preferred embodiments provide methods for making a composition for treating an animal with a growth hormone or growth hormone releasing factor, and methods for administering these substances to an animal.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: October 4, 1994
    Inventors: Norman D. Brooks, Gregory F. Needham