Patents Examined by Qing Xu
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Patent number: 11965190Abstract: Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin.Type: GrantFiled: September 7, 2018Date of Patent: April 23, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Yiannis John Kaznessis, Seth Ritter, Benjamin Hackel
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Patent number: 11957720Abstract: The present invention generally relates to the field of probiotic bacteria. In particular, it relates to methods for treating or preventing functional GI disorders comprising administering Bifidobacterium longum, such as Bifidobacterium longum ATCC BAA-999.Type: GrantFiled: April 27, 2022Date of Patent: April 16, 2024Assignee: Societe des Produits Nestle S.A.Inventors: Peter McLean, Gabriela Bergonzelli Degonda, Stephen Michael Collins, Premysl Bercik, Elena Verdu de Bercik
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Patent number: 11951138Abstract: A method of mimicking a phenotype of a first ruminating animal in a second ruminating animal is disclosed. The method comprises administering to the second ruminating animal a microbial composition comprising a plurality of microbes having a signature which is statistically significantly similar to the microbial signature of a rumen microbiome of the first ruminating animal, wherein the first and the second ruminating animal are of identical species, thereby mimicking the phenotype of the first ruminating animal in the second ruminating animal.Type: GrantFiled: March 13, 2014Date of Patent: April 9, 2024Assignee: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)Inventors: Itzhak Mizrahi, Elie Jami
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Patent number: 11932846Abstract: A system for expressing a chloramphenicol split protein is disclosed. Uses thereof are also disclosed.Type: GrantFiled: August 8, 2018Date of Patent: March 19, 2024Assignee: Technology Innovation Momentum Fund (Israel) Limited PartnershipInventor: Gali Prag
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Patent number: 11930824Abstract: The present algae extracts are used for biocontrol of insects. Specifically, the present extracts are obtained from Cystoseria muricatum using a polysolvent system. Once obtained, the extracts can be applied to plants to repel insects and/or to facilitate fertilization of the plants.Type: GrantFiled: March 22, 2023Date of Patent: March 19, 2024Assignee: KING FAISAL UNIVERSITYInventor: Nermin Adel El Semary
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Patent number: 11905315Abstract: Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g.Type: GrantFiled: October 26, 2020Date of Patent: February 20, 2024Assignee: SPOGEN BIOTECH INC.Inventors: Brian Thompson, Ashley Siegel
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Patent number: 11905539Abstract: A novel modified polypeptide having an isopropylmalate synthase activity, a polynucleotide encoding the same, a microorganism including the polypeptide, and a method of producing L-leucine by culturing the microorganism.Type: GrantFiled: January 25, 2021Date of Patent: February 20, 2024Assignee: CJ Cheiljedang CorporationInventors: Ji Hye Lee, Byeong Cheol Song, Ae Ji Jeon, Jong Hyun Kim, Hye Won Kim
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Patent number: 11875298Abstract: An NADP(H) nanosensor has i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.Type: GrantFiled: July 22, 2019Date of Patent: January 16, 2024Assignee: Forschungszentrum Julich GMBHInventors: Solvej Siedler, Georg Schendzielorz, Stephan Binder, Lothar Eggeling, Stephanie Bringer-Meyer, Michael Bott
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Patent number: 11850451Abstract: The invention relates to the use of an agent and a composition, respectively, comprising the following active ingredients: a) an aromatase inhibitor and/or a 5-?-reductase inhibitor, b) an antioxidant, and c) hyaluronic acid for cosmetic purposes.Type: GrantFiled: August 4, 2020Date of Patent: December 26, 2023Assignee: Lucolas-M.D. Ltd.Inventor: Alfred Schmidt
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Patent number: 11845927Abstract: Certain disclosed embodiments concern a bioremediation composition comprising microbial cells, at least one co-metabolism substrate to induce selected enzyme production by the microbial cells, and a bead or gel encapsulating the microbial cells, such as bacterial or fungi cells, and the at least one co-metabolism substrate. For certain embodiments, the substrate is a slow release compound, such as an orthosilicate that hydrolyzes to produce an alcohol growth substrate. Embodiments of a method for using the composition to transform contaminants of concern also are disclosed.Type: GrantFiled: November 20, 2019Date of Patent: December 19, 2023Assignees: Oregon State University, North Carolina State UniversityInventors: Lewis Semprini, Mitchell Rasmussen, Michael R. Hyman
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Patent number: 11846640Abstract: The present invention is directed to a novel method of determining inhibitors of proteolytically active coagulation factors, referred to herein as anticoagulants, in a sample, in particular the qualitative detection of direct thrombin and factor Xa inhibitors in a sample. The method of the present invention allows a qualitative determination of the nature anticoagulants present in a sample. This can be achieved with only one coagulation-based test. The method can be used in a test kit, including a point-of-care (POC) system.Type: GrantFiled: April 9, 2019Date of Patent: December 19, 2023Assignee: PENTAPHARM AGInventors: Abel Ferrandez, Anne Brisset
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Patent number: 11839634Abstract: The present invention relates to the use of a composition comprising bacteria to increase the intestinal production of butyric acid, folic acid or niacin and/or to decrease the intestinal production of succinic acid. Moreover, the present invention relates to the use of said composition for the treatment and/or prevention of an intestinal butyrate- and/or succinate-dependent pathological condition. In particular, for the treatment and/or the prevention of intestinal inflammation, diarrhoea, ulcerative colitis or intestinal colopathies.Type: GrantFiled: September 5, 2014Date of Patent: December 12, 2023Assignee: ALFASIGMA S.P.A.Inventors: Simone Domenico Guglielmetti, Ruggero Rossi, Walter Fiore, Andrea Biffi
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Process for determining enzyme activity in a cell by activity-based reporter gene technology (ABRGT)
Patent number: 11834698Abstract: Methods and materials for specific imaging of active enzyme in a live or intact cell are disclosed. The enzyme of interest tagged to reporter protein (donor) is exogenously expressed in a cell. The conversion of proenzyme to active enzyme (containing reporter protein) is achieved upon applying an appropriate stimulus to the target cells. The activated enzyme is labelled with an activity-based probe carrying a fluorophore (acceptor). The covalent labelling of active enzyme by the activity-based probe creates a FRET pair which provides the opportunity to exquisitely image the function of an “active enzyme”. This method is used for specific imaging of the function of active caspase-3,-7,-8,-9 and cathepsin-B and also for profiling of inhibitors of caspases and cathepsin B.Type: GrantFiled: May 2, 2019Date of Patent: December 5, 2023Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCHInventors: Sandanaraj Selvaraj Britto, Punita Bathla -
Patent number: 11819844Abstract: A process for evaluating efficacy of a deodorant product includes: introducing sweat into a main channel formed in a fluidic device satisfying particular requirements; measuring a flow rate of the sweat in the main channel and transmitting the flow rate to a controller; imposing a pressure set point on the pressure actuator by closed-loop control so the flow rate of the sweat in the main channel is controllable; contacting the sweat and a deodorant product and reacting the sweat and the deodorant product with each other, the deodorant product being provided in a particular manner, wherein while the sweat and the deodorant product react with each other, the flow rate of the sweat in the main channel is maintained at substantially zero; and determining at least one of a physicochemical parameter and a biological parameter of a product of the reaction between the sweat and a the deodorant product.Type: GrantFiled: March 24, 2017Date of Patent: November 21, 2023Assignee: MICROFACTORYInventors: Jules Dupire, Fabrice Monti, Patrick Tabeling
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Patent number: 11805774Abstract: Described herein are methods and compositions for improving plant growth and other properties. The methods and compositions utilize bacteria and bacterial exudates incorporated into plant seeds for improvement of plant growth and other properties.Type: GrantFiled: November 5, 2021Date of Patent: November 7, 2023Assignee: ANDES AG, INC.Inventors: Gonzalo Fuenzalida, Tania Timmermann, Roque Giordano, Veronica Morgante
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Patent number: 11806462Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.Type: GrantFiled: April 6, 2021Date of Patent: November 7, 2023Assignee: Arthrex, Inc.Inventor: Christopher Bare
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Patent number: 11759505Abstract: The present invention relates to a method for isolating Glu-plasminogen, said method comprising the anion exchange chromatography of blood plasma or a plasma fraction comprising Glu-plasminogen. Furthermore, the present invention relates to Glu-plasminogen obtainable from the method of the present invention and its use in a method for treating a patient suffering from or being at risk of developing a disorder selected from the group consisting of organ failure, a thrombotic event, arterial obstructive disease, microcirculation, disseminated intravascular coagulation (DIC), and a combination of two or more thereof.Type: GrantFiled: March 9, 2018Date of Patent: September 19, 2023Assignee: PREVIPHARMA CONSULTING GMBHInventors: Ricarda Welz, Hanne Rieke Gerding, Marc Mazur, Stephan T. Kiessig, Hermann E. Karges
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Patent number: 11718892Abstract: The invention provides an assay for identifying a bacterium capable of binding elemental heavy metal, comprising the following steps: cultivating a test bacterium in a suitable first culture medium; immersing at least a surface portion of a test tool into the first culture medium for a second predetermined period of time, said surface portion being coated by elemental heavy metal, respectively; removing said test tool from said first culture medium and optionally rinsing the test tool; contacting a second culture medium with the surface portion coated by elemental heavy metal of said test tool removed in the previous step; and identifying the test bacterium as being capable of binding elemental heavy metal from growth of the test bacterium in said second culture medium.Type: GrantFiled: October 18, 2019Date of Patent: August 8, 2023Assignee: CvPlus GmbHInventors: Stephen Gos, Andrea Christiansen, Xin Lu, Guido Meurer, Yvonne Tiffert, Esther Gabor, Benedikt Hoffmann, Martin Langer
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Patent number: 11680250Abstract: The present disclosure relates to a light-driven system which is able to chemically modify an organic substrate with high efficiency and in a cost-effective manner. Also provided are methods for chemically modifying an organic substrate using the present systems and methods for manufacturing such systems.Type: GrantFiled: July 14, 2016Date of Patent: June 20, 2023Assignee: University of CopenhagenInventors: Claus Felby, David Cannella, Klaus Benedikt Möllers
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Patent number: 11659839Abstract: Provided is a component having plant defense activity. A PR1 gene expression activator containing a culture of a unicellular alga containing a green photosynthetic pigment as an active ingredient; A plant defense activator containing a culture of a unicellular alga containing a green photosynthetic pigment as an active ingredient; A plant disease preventive or ameliorating agent containing a culture of a unicellular alga containing a green photosynthetic pigment as an active ingredient; and a method of producing a plant defense activating component containing: cultivating a unicellular alga containing a green photosynthetic pigment under an aerobic condition to produce a culture containing an extracellular polysaccharide.Type: GrantFiled: March 22, 2019Date of Patent: May 30, 2023Assignees: PANAC CO., LTD., NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATIONInventors: Gouki Satou, Toshichika Ooki, Masahiro Koide, Hiroshi Sekiguchi