Abstract: Disclosed is a method for preparing high-load oral paclitaxel capsule for a slow release in colon, belonging to the field of porous starch drug loading. The preparation method of the present disclosure includes the following steps: (1) dripping an ethanol solution of paclitaxel into a water phase and drying the solution to obtain an amorphous paclitaxel microsphere; (2) redissolving the paclitaxel microsphere prepared in step (1) in the ethanol solution, dispersing porous starch in the ethanol solution for adsorption, volatilizing a solvent in an oven, washing the porous starch with the ethanol solution to remove unadsorbed paclitaxel, and centrifuging same to obtain a precipitate, namely the porous starch loaded with paclitaxel; and (3) dispersing the porous starch loaded with paclitaxel prepared in step (2) in a chitosan solution, dropwise adding the solution into a phytic acid solution, and stirring the solution for 4 hours to obtain a coated capsule.
Type:
Grant
Filed:
March 27, 2023
Date of Patent:
October 3, 2023
Assignee:
JIANGNAN UNIVERSITY
Inventors:
Yan Hong, Beibei Zhao, Zhengbiao Gu, Li Cheng, Zhaofeng Li, Caiming Li, Xiaofeng Ban
Abstract: An abuse deterrent and misuse deterrent transdermal patch comprising aversive agents incorporated in the backing layer of the patch. The aversive agents can exhibit biphasic or sustained kinetics of release with an immediate portion released rapidly and an extended portion released in a prolonged manner when exposed to a dissolution medium. The prolonged aversive agent release provides deterrence against extraction of drug from fresh and used patches and serves to prevent accidental misuse of used patches by children. The abuse deterrent and misuse deterrent patch systems can be used for transdermal delivery of therapeutically active agents and particularly those drugs that are highly prone to abuse such as opiate and opioid analgesics and stimulants.
Type:
Grant
Filed:
January 5, 2022
Date of Patent:
September 19, 2023
Assignee:
NUTRIBAND, INC.
Inventors:
David James Enscore, Frank Tagliaferri, Steven Paul Damon, Alan Smith, Jeffrey C. Gaulding
Abstract: A cosmetic composition is provided. The cosmetic composition includes Astrocaryum vulgare oil and/or butter, which is useful in the production and/or protection against degradation of hyaluronic acid in the skin. Also provided are the process for the production of the cosmetic composition and related uses and methods.
Abstract: Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics. In preferred aspects, formulations comprise low quantities of one or more chelating agents, contain N-acetylcysteine at a concentration of 25 mg/mL or 50 mg/mL, and are packaged in a suitable format, such as a polymeric bag with a metalized overwrap and a non-contact oxygen scavenger.
Type:
Grant
Filed:
July 5, 2022
Date of Patent:
September 12, 2023
Assignee:
ENDO VENTURES LIMITED
Inventors:
Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
Abstract: The disclosure is directed to medroxyprogesterone compositions suitable for subcutaneous injection comprising about 260 mg/ml to 440 mg/ml medroxyprogesterone acetate, about 0.6 mg/ml to 1.5 mg/ml docusate sodium and, polyethylene glycol. Methods of using these compositions are also described.
Type:
Grant
Filed:
September 6, 2019
Date of Patent:
September 12, 2023
Assignee:
Family Health International
Inventors:
Prakash Sundaramurthi, Ivana Mijakovac, Andrea Rasic, Iva Tunjic
Abstract: Kombucha tea faces many challenges concerning its use for its health benefits, such as standardization, as well as the determination of a specific dosage form appropriate to the intended use. Kombucha tea, as a fermented, alcohol-containing beverage that relies on a complex combination of living yeast and bacteria for production, is especially difficult to administer. The present invention provides a consistent, standardized dosage form and novel combinations of a traditional medicinal drink that is otherwise unsuitable for widespread natural medicine. By providing kombucha as a soft, chewable and orally dissolvable and/or disintegrable compositions, such as a gummie, a gummie with probiotics, or a gummy made from tapioca syrup, a unique, desirable flavor and mouthfeel is obtained and which is also alcohol free. This expands the number of people who can enjoy the benefits of the traditional tea.
Abstract: A series of particles, in which each particle contains at least 3 wt. % of pigment(s) in relation to the weight of the particle, a method for producing the series of particles, and uses thereof in cosmetic compositions, particularly in make-up for keratinous materials.
Abstract: Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin D are disclosed. The 25-hydroxyvitamin D may be administered with an agent that increases the risk of hypocalcemia, such as cinacalcet or a salt thereof, and/or an anticancer agent. The adjunctive therapy is effective to treat and prevent iatrogenic hypocalcemia and/or secondary hyperparathyroidism, as well as delay cancer progression and the time to a post-treatment skeletal related event.
Type:
Grant
Filed:
May 11, 2021
Date of Patent:
August 29, 2023
Assignee:
EIRGEN PHARMA LTD.
Inventors:
P. Martin Petkovich, Joel Z. Melnick, Jay A. White, Samir P. Tabash, Charles W. Bishop, Susan Peers, Stephen A. Strugnell
Abstract: A stable liquid pharmaceutical formulation according to the present invention includes an antibody or antigen-binding fragment thereof, a surfactant, a sugar or a sugar derivative, a buffer, and a stabilizer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity not only when antibody content is low but also when antibody content is high, and exhibits superior long-term storage stability based on superior stability observed under accelerated conditions and harsh conditions.
Type:
Grant
Filed:
July 18, 2019
Date of Patent:
August 22, 2023
Assignee:
CELLTRION INC.
Inventors:
So Young Kim, Yeon Kyeong Shin, Hye Young Kang, Kwang Woo Kim, Jun Seok Oh, Su Jung Kim, Joon Won Lee, Won Yong Han, Jae Bin Lee, Ji Won Roh, Ji Min Kwak
Abstract: A composition for internal imaging of a subject includes an imaging contrast agent and one or more carrier agents that can pass through cellular and tissue membranes. Examples of imaging contrast agents are iodine-based, silver-based, or barium-based. Examples of carrier agents are dimethyl sulfoxide, urea, or an alcohol. Methods for internally imaging a subject using such a composition are also disclosed.
Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.
Abstract: Disclosed herein is a liquid pharmaceutical formulation substantially free of water, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin. Also disclosed herein is a liquid pharmaceutical formulation substantially free of water and ethanol, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin.
Type:
Grant
Filed:
June 15, 2022
Date of Patent:
August 15, 2023
Assignee:
LIQMEDS WORLDWIDE LIMITED
Inventors:
Jayanta Kumar Mandal, Malay Patel, Swati Nagar, Michael Paul DeHart
Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
Type:
Grant
Filed:
December 3, 2021
Date of Patent:
August 8, 2023
Assignee:
ALKERMES PHARMA IRELAND LIMITED
Inventors:
Niels P. Ryde, Peter Snyder, Wei Liu, David M. Slifer
Abstract: Disclosed herein is a fast-dispersing suspending composition which promotes the formation of a suspension for pharmaceutical, food and veterinary products. The composition includes a suspending agent, a diluent, and a glidant, wherein the amounts of these agents are selected to enable the dispersion of the composition and the formation of the suspension. Also disclosed are a method of forming a suspension of a solid dosage form and a method of administering the resulting suspension to a subject.
Type:
Grant
Filed:
June 8, 2022
Date of Patent:
August 1, 2023
Assignee:
AUSON PHARMACEUTICALS INC.
Inventors:
Enxian Lu, Peng Hou, Longlong Feng, Long Wang
Abstract: The kit for locating a vein is configured for use in inserting an intravenous (IV) catheter into a targeted vein of a patient. The kit for locating a vein is a transparent structure. The kit for locating a vein: a) removably attaches to the skin of the patient; b) numbs the skin of the patient; c) generates a vasomotor response; d) provides the ability to insert the IV catheter into the targeted vein while the kit for locating a vein remains attached to the patient; and, e) forms a dressing that captures bodily fluids. The kit for locating a vein comprises a parchment sheeting, a working media, a transparent pocket, and a plurality of apertures. The parchment sheeting, the working media, and the transparent pocket form a transparent composite textile structure. The plurality of apertures are apertures that are formed through the composite textile structure.
Abstract: Ultraviolet radiation sun protective compositions are reported which feature micronized metal oxide inorganic particles selected from zinc oxide, titanium oxide and mixtures thereof, the inorganic particles being coated with poly[C8-C20 hydroxycarboxylic acid], the coated particles measured at a 10% loading in dodecane and 1 minute elapsed time having a Zeta Potential ranging from 2 to 10 mv, amounts of the poly[C8-C20 hydroxycarboxylic acid] to the inorganic particles being in a relative weight ratio of 1:100 to 1:10.
Abstract: Compositions include highly-concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly-concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).
Type:
Grant
Filed:
September 22, 2021
Date of Patent:
July 18, 2023
Assignee:
GRIFOLS WORLDWIDE OPERATIONS LIMITED
Inventors:
James Rebbeor, Charles Miller, Anthony Klos, Eric Allgaier, Thomas P. Zimmerman, Kevin Wee, Michelle StPeter, Kelly Glancy
Abstract: Calcium hydroxide nanoparticles (Ca(OH)2NPs) synthesized using carob pulp extract may be hexagonal nanoparticles with a diameter ranging from about 31.22 nm to about 81.22 nm. The Ca(OH)2NPs may be synthesized by heating ethylene glycol, adding calcium hydroxide to the ethylene glycol to provide a first mixture, heating the first mixture, adding a carob pulp aqueous extract to the first mixture to form a second mixture, heating the second mixture, adding sodium hydroxide (NaOH) to the second mixture to form a third mixture, heating the third mixture, resting the third mixture at room temperature after heating, centrifuging the third mixture, collecting a colloid sediment, extracting any unwanted contaminants from the colloid sediment, and drying the colloid sediment to obtain Ca(OH)2NPs.
Type:
Grant
Filed:
September 14, 2020
Date of Patent:
July 11, 2023
Assignee:
KING SAUD UNIVERSITY
Inventors:
Mohamad Saleh Alsalhi, Sandhanasamy Devanesan, Rawan Ibrahim Salem Alkhalaf, Hajer Saad Abdullah Allayed, Nasser Raqe Rashed Alqhtani, Mohammed Ghazi Alkindi, Osama Ghurmullah Mohammed Alghamdi
Abstract: Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.
Type:
Grant
Filed:
April 5, 2021
Date of Patent:
July 4, 2023
Assignee:
Boston Scientific Limited
Inventors:
Martin Lawrence Fawdry, Aiden Flanagan, Matthew McEvaddy, Garry Duffy, Eamonn J. Tuohy