Patents Examined by R. Kearse
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Patent number: 5013539Abstract: The present invention improves the safety of the use of sodium nitroprusside in the clinical setting. Specifically, this invention utilizes .alpha.-ketoglutaric acid or .alpha.-ketoglutaric acid and sodium thiosulfate to reduce sodium nitroprusside's toxic effects.Type: GrantFiled: March 4, 1986Date of Patent: May 7, 1991Inventors: James C. Norris, Arthur S. Hume
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Patent number: 4906660Abstract: A wood preservative composition and method comprising an aqueous solution of a monoalkanolamine and a copper octoate.Type: GrantFiled: May 13, 1987Date of Patent: March 6, 1990Assignee: Chapman Chemical CompanyInventor: Michael H. West
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Patent number: 4882170Abstract: There is described a method for the prevention or inhibition of an allergic reaction or tissue inflammation resulting from the placement of an endotracheal instrument or device, which method comprises administration by inhalation of an anti-allergy drug to a patient prior to the placement, during the placement, or while the instrument or device is in place.There are also described pharmaceutical mixtures comprising, as a first component, an anti-allergy drug and, as a second component, a substance conventionally administered by endotracheal intubation.Type: GrantFiled: March 20, 1987Date of Patent: November 21, 1989Assignee: Fisons CorporationInventors: Rogelio Menendez, Kenneth J. Gorelick
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Patent number: 4876090Abstract: A systemic insect repellent composition is provided which affords essentially continuous protection of domesticated animals against fleas, ticks and other blood feeding pests. The systemic compositions of the invention comprise two essential ingredients: Vitamin B.sub.1 and allyl sulfide (garlic oil) dissolved in a soybean oil base. The composition is preferably consumed by the animal during its normal feeding. The dosage consumed by the animal is adjusted to provide a prescribed minimal blood level which insures continuous insect repellency. Unlike the more popular preparations, this composition is not inherently toxic, is not offensive to the animal and does not give the animal bad breath.Type: GrantFiled: September 21, 1987Date of Patent: October 24, 1989Inventor: Richard Weisler
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Patent number: 4873249Abstract: The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.The pharmaceutical compositions of the present invention exhibit the desired analgesic and anti-inflammatory effect without causing undesired ulcerogenic side-effects.Type: GrantFiled: February 20, 1987Date of Patent: October 10, 1989Assignee: EGIS GyogyszergyarInventors: Lujza Petocz, Istvan Simonyi, Ivan Beck, Gabor Gigler, Marton Fekete, Eniko Kiszelly, Attila Mandi, Frigyes Gorgenyi, Andras Dietz, Katalin Sumeg nee Zukovics, Elemer Jakfalvi
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Patent number: 4863740Abstract: Interleukin-2 liposomes are advantageous sustained release formulations.Type: GrantFiled: May 12, 1988Date of Patent: September 5, 1989Assignee: Sandoz Ltd.Inventors: Thomas Kissel, Jurg Reinhardt, Henriette Schrank
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Patent number: 4861778Abstract: A compound having the structural formula ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 carbalkoxyalkyl or phenyl substituted with C.sub.1 -C.sub.3 alkyl or halogen; R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R.sup.3 and R.sup.4 are the same or different and are hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or halogen with the provisos that if R.sup.2, R.sup.3 and R.sup.4 are hydrogen, then R.sup.1 is not methyl, n-propyl or phenyl substituted with methyl in the ortho or para position; if R.sup.1, R.sup.2 and R.sup.3 are hydrogen then R.sup.4 is not hydrogen, methyl or methoxy; and if R.sup.1 and R.sup.2 are both n-propyl or n-butyl then R.sup.3 and R.sup.4 are not both hydrogen. These compounds demonstrate utility as hypolipidemic agents.Type: GrantFiled: June 16, 1986Date of Patent: August 29, 1989Assignee: Research CorporationInventors: Iris H. Hall, Steven D. Wyrick, James M. Chapman, Jr.
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Patent number: 4853210Abstract: This invention relates to the cytology of blood, bone marrow, and lumpth node cells, and a method of differentiating, identifying, and enumerating said cells among a plurality of cells of hematopoietic origin. More specifically, the invention is directed to the use of basic cationic diazo dyes capable of staining a plurality of cells of hematopoietic origin to differentiate and enumerate the abnormal from the normal cells. The stained cells obtained by this invention have individual color characteristics which permit the identification and differentiation by use of various optical instruments, including, for example, an image analyzer, microscope, photomicroscope and the like.Type: GrantFiled: January 26, 1988Date of Patent: August 1, 1989Assignee: Cytocolor, Inc.Inventor: Lawrence Kass
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Patent number: 4851449Abstract: An odorless sterilizing and disinfecting solution containing 0.025 to 1.0 weight percent phthalaldehyde.Type: GrantFiled: May 21, 1987Date of Patent: July 25, 1989Assignee: Surgikos, Inc.Inventors: Norman I. Bruckner, Michael D. Gordon, Ronald G. Howell
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Patent number: 4849425Abstract: A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z.sub.2 is a hydrogen atom, Z.sub.1 is a halogen atom, and A is a nitrogen atom, and at least one member selected from the group consisting of a cyclodextrin, a polyethylene glycol and a refined oil.Type: GrantFiled: January 30, 1986Date of Patent: July 18, 1989Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Nobuo Kondo, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Tadakazu Suyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 4840960Abstract: A method for treating a patient suffering from glomerulonephritis comprising administering to the patient an effective amount of nitrendipine.Type: GrantFiled: August 25, 1987Date of Patent: June 20, 1989Assignee: Miles Laboratories, Inc.Inventors: R. Bernd Sterzel, Alexander Scriabine
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Patent number: 4839389Abstract: Polyprenyl alcohol-containing injections comprising polyprenyl alcohols shown by the formula: ##STR1## wherein n is an integer of 5 to 7, and lecithin as essential ingredients. The subject injections can enhance utilization of the polyprenyl alcohols contained therein in vivo, thereby effectively preventing or treating infectious diseases in humans or animals.Type: GrantFiled: January 23, 1987Date of Patent: June 13, 1989Assignee: Eisai Co., Ltd.Inventors: Noritoshi Koyama, Takayuki Ikeuchi, Seiichi Araki, Kyosuke Kitoh, Katsumi Ida
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Patent number: 4839168Abstract: Hair cosmetic compositions comprise (A) an extract obtained by polar solvent extraction of a plant, preferable ones of which are birch, rosemary and hamamelis, and (B) a polypeptide compound including keratin, keratin derivative, silk and hydrolysate of silk.Such compositions are made into shampoo, rinse, set lotion, hair spray, etc.Hair cosmetics according to the invention can impart good hair style retentivity and good touch of feeling.Type: GrantFiled: October 2, 1986Date of Patent: June 13, 1989Assignee: Kao CorporationInventors: Yoshiaki Abe, Hidetoshi Iwabuchi
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Patent number: 4780311Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or a pharmaceutically acceptable salt thereof, are .beta.-ketoacyl-coenzyme A thiolase inhibitors and are useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.Type: GrantFiled: May 26, 1987Date of Patent: October 25, 1988Assignee: Merck & Co., Inc.Inventors: Janet Onishi, Michael Greenspan
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Patent number: 4780308Abstract: Oral or parenteral administration of 10 to 30 mg/kg/day of L-carnitine (or an equivalent amount of a pharmacologically acceptable salt thereof) both during preanesthesia and post-operative phase antagonizes the toxic effects (particularly on kidneys and liver) induced by inhalation of halogen-containing general anesthetics such as, typically, halotane.Type: GrantFiled: July 2, 1987Date of Patent: October 25, 1988Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Noris Siliprandi, Guido Scutari
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Patent number: 4775681Abstract: A method of treating fungal infections comprises administering an antifungally effective amount of a trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-one compound or a .beta.,.delta.-hydroxyheptanoic acid corresponding thereto.Type: GrantFiled: June 18, 1987Date of Patent: October 4, 1988Assignee: Warner-Lambert CompanyInventor: Carl L. Heifetz