Patents Examined by R. Kearse
  • Patent number: 5013539
    Abstract: The present invention improves the safety of the use of sodium nitroprusside in the clinical setting. Specifically, this invention utilizes .alpha.-ketoglutaric acid or .alpha.-ketoglutaric acid and sodium thiosulfate to reduce sodium nitroprusside's toxic effects.
    Type: Grant
    Filed: March 4, 1986
    Date of Patent: May 7, 1991
    Inventors: James C. Norris, Arthur S. Hume
  • Patent number: 4906660
    Abstract: A wood preservative composition and method comprising an aqueous solution of a monoalkanolamine and a copper octoate.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: March 6, 1990
    Assignee: Chapman Chemical Company
    Inventor: Michael H. West
  • Patent number: 4882170
    Abstract: There is described a method for the prevention or inhibition of an allergic reaction or tissue inflammation resulting from the placement of an endotracheal instrument or device, which method comprises administration by inhalation of an anti-allergy drug to a patient prior to the placement, during the placement, or while the instrument or device is in place.There are also described pharmaceutical mixtures comprising, as a first component, an anti-allergy drug and, as a second component, a substance conventionally administered by endotracheal intubation.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: November 21, 1989
    Assignee: Fisons Corporation
    Inventors: Rogelio Menendez, Kenneth J. Gorelick
  • Patent number: 4876090
    Abstract: A systemic insect repellent composition is provided which affords essentially continuous protection of domesticated animals against fleas, ticks and other blood feeding pests. The systemic compositions of the invention comprise two essential ingredients: Vitamin B.sub.1 and allyl sulfide (garlic oil) dissolved in a soybean oil base. The composition is preferably consumed by the animal during its normal feeding. The dosage consumed by the animal is adjusted to provide a prescribed minimal blood level which insures continuous insect repellency. Unlike the more popular preparations, this composition is not inherently toxic, is not offensive to the animal and does not give the animal bad breath.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: October 24, 1989
    Inventor: Richard Weisler
  • Patent number: 4873249
    Abstract: The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.The pharmaceutical compositions of the present invention exhibit the desired analgesic and anti-inflammatory effect without causing undesired ulcerogenic side-effects.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: October 10, 1989
    Assignee: EGIS Gyogyszergyar
    Inventors: Lujza Petocz, Istvan Simonyi, Ivan Beck, Gabor Gigler, Marton Fekete, Eniko Kiszelly, Attila Mandi, Frigyes Gorgenyi, Andras Dietz, Katalin Sumeg nee Zukovics, Elemer Jakfalvi
  • Patent number: 4863740
    Abstract: Interleukin-2 liposomes are advantageous sustained release formulations.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: September 5, 1989
    Assignee: Sandoz Ltd.
    Inventors: Thomas Kissel, Jurg Reinhardt, Henriette Schrank
  • Patent number: 4861778
    Abstract: A compound having the structural formula ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 carbalkoxyalkyl or phenyl substituted with C.sub.1 -C.sub.3 alkyl or halogen; R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R.sup.3 and R.sup.4 are the same or different and are hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or halogen with the provisos that if R.sup.2, R.sup.3 and R.sup.4 are hydrogen, then R.sup.1 is not methyl, n-propyl or phenyl substituted with methyl in the ortho or para position; if R.sup.1, R.sup.2 and R.sup.3 are hydrogen then R.sup.4 is not hydrogen, methyl or methoxy; and if R.sup.1 and R.sup.2 are both n-propyl or n-butyl then R.sup.3 and R.sup.4 are not both hydrogen. These compounds demonstrate utility as hypolipidemic agents.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: August 29, 1989
    Assignee: Research Corporation
    Inventors: Iris H. Hall, Steven D. Wyrick, James M. Chapman, Jr.
  • Patent number: 4853210
    Abstract: This invention relates to the cytology of blood, bone marrow, and lumpth node cells, and a method of differentiating, identifying, and enumerating said cells among a plurality of cells of hematopoietic origin. More specifically, the invention is directed to the use of basic cationic diazo dyes capable of staining a plurality of cells of hematopoietic origin to differentiate and enumerate the abnormal from the normal cells. The stained cells obtained by this invention have individual color characteristics which permit the identification and differentiation by use of various optical instruments, including, for example, an image analyzer, microscope, photomicroscope and the like.
    Type: Grant
    Filed: January 26, 1988
    Date of Patent: August 1, 1989
    Assignee: Cytocolor, Inc.
    Inventor: Lawrence Kass
  • Patent number: 4851449
    Abstract: An odorless sterilizing and disinfecting solution containing 0.025 to 1.0 weight percent phthalaldehyde.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: July 25, 1989
    Assignee: Surgikos, Inc.
    Inventors: Norman I. Bruckner, Michael D. Gordon, Ronald G. Howell
  • Patent number: 4849425
    Abstract: A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z.sub.2 is a hydrogen atom, Z.sub.1 is a halogen atom, and A is a nitrogen atom, and at least one member selected from the group consisting of a cyclodextrin, a polyethylene glycol and a refined oil.
    Type: Grant
    Filed: January 30, 1986
    Date of Patent: July 18, 1989
    Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross Corporation
    Inventors: Nobuo Kondo, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Tadakazu Suyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
  • Patent number: 4840960
    Abstract: A method for treating a patient suffering from glomerulonephritis comprising administering to the patient an effective amount of nitrendipine.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: June 20, 1989
    Assignee: Miles Laboratories, Inc.
    Inventors: R. Bernd Sterzel, Alexander Scriabine
  • Patent number: 4839389
    Abstract: Polyprenyl alcohol-containing injections comprising polyprenyl alcohols shown by the formula: ##STR1## wherein n is an integer of 5 to 7, and lecithin as essential ingredients. The subject injections can enhance utilization of the polyprenyl alcohols contained therein in vivo, thereby effectively preventing or treating infectious diseases in humans or animals.
    Type: Grant
    Filed: January 23, 1987
    Date of Patent: June 13, 1989
    Assignee: Eisai Co., Ltd.
    Inventors: Noritoshi Koyama, Takayuki Ikeuchi, Seiichi Araki, Kyosuke Kitoh, Katsumi Ida
  • Patent number: 4839168
    Abstract: Hair cosmetic compositions comprise (A) an extract obtained by polar solvent extraction of a plant, preferable ones of which are birch, rosemary and hamamelis, and (B) a polypeptide compound including keratin, keratin derivative, silk and hydrolysate of silk.Such compositions are made into shampoo, rinse, set lotion, hair spray, etc.Hair cosmetics according to the invention can impart good hair style retentivity and good touch of feeling.
    Type: Grant
    Filed: October 2, 1986
    Date of Patent: June 13, 1989
    Assignee: Kao Corporation
    Inventors: Yoshiaki Abe, Hidetoshi Iwabuchi
  • Patent number: 4780311
    Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or a pharmaceutically acceptable salt thereof, are .beta.-ketoacyl-coenzyme A thiolase inhibitors and are useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: October 25, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Janet Onishi, Michael Greenspan
  • Patent number: 4780308
    Abstract: Oral or parenteral administration of 10 to 30 mg/kg/day of L-carnitine (or an equivalent amount of a pharmacologically acceptable salt thereof) both during preanesthesia and post-operative phase antagonizes the toxic effects (particularly on kidneys and liver) induced by inhalation of halogen-containing general anesthetics such as, typically, halotane.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: October 25, 1988
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Noris Siliprandi, Guido Scutari
  • Patent number: 4775681
    Abstract: A method of treating fungal infections comprises administering an antifungally effective amount of a trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-one compound or a .beta.,.delta.-hydroxyheptanoic acid corresponding thereto.
    Type: Grant
    Filed: June 18, 1987
    Date of Patent: October 4, 1988
    Assignee: Warner-Lambert Company
    Inventor: Carl L. Heifetz