Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.
Type:
Grant
Filed:
December 11, 1998
Date of Patent:
April 30, 2002
Assignee:
Eli Lilly and Company
Inventors:
Ronald Norbert Hermeling, James Arthur Hoffmann, Chakravarthy Narasimhan