Abstract: A multi-piece solid golf ball including a relatively soft core, a very soft intermediate layer, and a thermoplastic resin-based cover harder than the intermediate layer by at least 20 Shore D units. The product (AxB) of the Shore D hardnesses of the cover and the intermediate layer and a dimple volume ratio VR (%) satisfy a specific relationship, and at least three types of dimples which are different in at least one of diameter, depth, and V0 are formed on the ball surface. The ball has a very soft pleasant feel upon approach shots and putting, ease of control upon iron shots, and a satisfactory trajectory and improved flight performance upon full shots with a driver.