Abstract: The strength of a nitroglycerin dosage to be administered to patients suffering from angina can be reduced when a portion of the dosage is replaced with menthol containing substances (MCS). MCS and specifically 1% Menthol has been found to potentate the effect of nitroglycerin. Accordingly, MCS can be used as a substitute for a portion of the nitroglycerin dosage administered to a patient. Side-effects common to nitroglycerin usage such as headache and fainting are significantly reduced when a nitroglycerin/MCS solution is used which has 50% of the nitroglycerin dosage per spray commonly used without sacrificing treatment effectiveness.
Abstract: The invention described herein relates to the use of calcium channel blockers such as amlodipine in the treatment of renal disease in normotensive animals. Also described are new unit doses of amlodipine suitable for the treatment of renal disease in normotensive cats.
Abstract: A method for treating an atopic disorder in a patient is provided. The method comprises administering to the patient an effective amount of at least one of an antifungal and an antibiotic over a period of time. The method further comprises reducing over the period of time the application of emollients to the patient by at least about 50%, relative to the amount of application of emollients prior to treatment.
Abstract: The present invention relates to the use of an angiotensin II type 1 receptor antagonist in the manufacture of a medicament for the prophylactic and/or therapeutic treatment of cardiovascular complications encountered in a patient in need of dialysis. The invention further relates to a method for prophylactic and/or therapeutic treatment of cardiovascular complications encountered in a patient in need of dialysis, comprising administering to the patient a therapeutically effective amount of an angiotensin II type 1 receptor antagonist.
Type:
Grant
Filed:
December 22, 2000
Date of Patent:
November 26, 2002
Assignee:
AstraZeneca AB
Inventors:
Erling Bjerregaard Pedersen, Friedrich Luft, Anders Svensson, Faies Zannad
Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula:
R—NH—(CH2)a—NH—(CH2)bH—(CH2)c—NH2, 1)
CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)dNH—(CH2)e—C6H5—CF3, 2)
R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R 3)
and
PIP—(CH2)a—NH—(CH2)b—NH—(CH2)c—PIP, 4)
wherein:
R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom,
PIP is piperidine and
a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.