Abstract: A device for injecting a medicament is provided. The device has a housing with a container within it which can hold a medicament. At its proximal end the container has a needle and a stopper. The device includes a plunger which at one end can engage the stopper. At the opposite end, the plunger can engage a first resilient member to move the stopper within the container to inject the medicament from the container. The device includes a collar with distal and proximal ends, the distal end engaging with a carriage and causing its rotation and the proximal end engaging with a second resilient member. The second resilient member can engage with a skin sensor which has distal and proximal ends. At the proximal end, the skin sensor can contact an injection site. The housing has a cap which can reduce or prevent movement of the skin sensor.

Abstract: A system includes an implantable device including a pump to pump the fluid from the peritoneum to the bladder via respective catheters, control circuitry, battery and transceiver; a charging and communication system configured to periodically charge the battery and communicate with the implantable device to retrieve data reflective of the patient's health; and monitoring and control software, suitable for use with conventional personal computers, for configuring and controlling operation of the implantable device and charging and communication system. The monitoring and control software allows a treating physician to remotely adjust the volume, time, and frequency with which fluid is pumped from the peritoneal cavity to the bladder based on the data reflective of the patient's health.

Abstract: A method and an apparatus for applying an anesthetic that includes a receptacle having an upper end, a substantially hollow interior, a lower end having a tube or nozzle extending therefrom, and an attachment for attaching to the barrel of a syringe or vice versa. The receptacle receives a container or canister containing an endothermic gas or vapor (propellant) that rapidly absorbs heat when released to the atmosphere. A depressible actuating member or trigger propels the gas or vapor through an outlet nozzle that is oriented to project a stream of gas or vapor along a delivery axis that intersects a delivery axis of the needle, therefore, the gas or vapor can be successively delivered to an injection site with minimal repositioning of the housing.

Abstract: A morselizer comprising (a) a hollow cylindrical structure with an inner wall and an outer wall and comprising a first end section, a second end section, and a center section extending axially between the first end section and the second end section providing a substantially axial liquid pathway therein; (b) wherein each end section comprises a axially and radially hollow luer fitting that is attachable to a structure with a complementarily sized luer fitting; and (c) one or more blades extending transversally across the inner diameter of the center section wherein (i) each blade is comprised of a plurality of ends, including a posterior end secured to at least the center wall section inner wall at a center section inner wall first position and an anterior end proximal a center section inner wall second position opposite the center section inner wall first position, with a gap positioned between the blade anterior end and the center section inner wall second position, and (ii) at least two ends comprise cutti

Abstract: A transvascularly placed steerable microcatheter, further including internal steerability and the ability to articulate in a direction at right angles to its longitudinal axis at or near its distal end. The steerable microcatheter is generally fabricated from stainless steel, nitinol, or other metal and includes an outer tube, an inner tube, hub structures, and a distal articulating region. The steerable microcatheter can be advanced through a body lumen in its straight configuration and then be selectively articulated or curved to permit negotiation of tortuous curvature. The microcatheter is especially suited to robotic or powered control applications with user intervention or using artificial intelligence (AI).

Abstract: Devices and methods for delivering treatment fluids or particulates such as, stem cells, drugs, Botox and like, to an inner lining of a bladder for treatment of urinary tract disorders, including over-active bladder. A balloon delivery system can include an inflation balloon having a plurality of micro-needles configured to pierce and otherwise puncture an inner bladder wall so as to deliver the treatment fluid to bladder tissue. The treatment fluid can be directly injected into the bladder tissue using the micro needles. Alternatively, the micro needles can be fabricated of bioabsorbable or bioresorbable materials such that the micro needles can remain embedded within the bladder tissue to deliver the treatment fluid or particulate.

Abstract: Multi-medicament infusion systems prevent cross-channeling of medicaments. A system may include one or more of an infusion pump, medicament reservoirs, a multi-channel fluid conduit, and an infusion set. Medicament reservoirs and/or collars may be sized and shaped differently such that the medicament reservoirs can only be inserted into the system under selected configurations.

Abstract: A medicine dispensing device and system for administering a selected drug. The medicine dispensing device includes a vessel configured to retain a drug to be dispensed. The medicine dispensing device may comprise a first series of zones of varying widths on a surface of the vessel, with each zone of the first series of zones corresponding to a pre-determined dose of the drug for a first medical condition wherein the first series of zones are correlated to a first series of values of a physical characteristic of a patient; and a second series of zones of varying widths on the surface of the vessel, with each zone of the second series of zones corresponding to a pre-determined dose of the drug for a second medical condition wherein the second series of zones are correlated to a second series of values of the physical characteristic of a patient.

Abstract: Single use hydraulic drive devices and single use large volume injectors are described. A method for single use hydraulic drive including releasing a holding device to move a catalyst coated portion of a rod into a reagent filled chamber, generating pressure in the chamber due to at least one of gas creation and thermal expansion from a chemical reaction between the catalyst coated portion and the reagent, hydraulically displacing a movable object in hydraulic communication with the chamber, and stopping further chemical reaction when the pressure exceeds a holding device force threshold to enable the holding device to re-hold a retracted catalyst coated portion of the rod outside of the chamber. The self-regulating pressure in the chamber enables a controlled rate of hydraulic displacement of the movable object.

Abstract: A conduit connector for an enteral feeding pump includes a fluid inlet portion that has an inlet axis and a fluid outlet portion that has an outlet axis that is parallel to and laterally offset from the inlet axis. The fluid inlet portion defines an elongated side slot extending parallel to the inlet axis for receiving tubing therethrough. The conduit connector further includes a bridge portion that extends between and connects the fluid inlet portion and the fluid outlet portion.

Abstract: Aspects of articulating devices and methods are disclosed. An exemplary articulating device may comprise an interior core with a reinforcing extending along a central axis, an exterior layer bonded to the interior core by an interface, and a lumen extending through the exterior layer, exterior of the reinforcing element, and parallel to the central axis. A steering wire may be moveable in the lumen to articulate a distal end of the device relative to the central axis in response to a force applied to the steering wire. Related methods of manufacturing an articulating device are also described.

Abstract: A large lumen guide catheter has an elongate tubular body, which has an outer surface, an inner surface, and a braided wire layer between the inner surface and the outer surface, wherein the wires winding a first helical direction are thicker and wider than the wire winding in a second helical direction opposite the first helical direction.

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

Abstract: Medical devices including a cap for a medical connector are disclosed. In some embodiments, the cap comprises a disinfectant, such as an antiseptic fluid and an insert configured to seal or partially seal the medical connector as it is engaged with the cap. In some embodiments the cap insert has a segment which is deformable under axially applied pressure as an end-user attaches the cap to the medical connector. In some embodiments this insert is configured to improve the exposure of antiseptic to the outer surface of the medical connector while minimizing exposure of the antiseptic inside the medical connector open lumen.

Abstract: A plungerless aspiration and/or injection device and a method of using the same are disclosed herein. The plungerless aspiration and/or injection device includes a housing; a needle portion disposed in the housing, the needle portion configured to be selectively retracted and extended by a user, the needle potion comprising a needle tip configured to be inserted into tissue of a patient for aspiration, injection, and/or implantation; and a bulb portion disposed in the housing, the bulb portion defining a fluid containing cavity that is fluidly coupled to the needle portion, and the bulb portion being elastically deformable so that the user is able to perform the aspiration, the injection, and/or the implantation on the patient by manipulating the bulb portion.

Abstract: Aspects of the disclosure relate to medical catheters, including electrophysiological catheters, comprising a catheter maintaining at least one electrode including a plurality of electrode segments. The catheter can include a plurality of slots in which the electrodes can be secured so that the electrodes are at least partially positioned within a center lumen of the catheter. Methods of manufacturing medical catheters are also disclosed. In various methods of assembling a catheter, a hollow, tubular catheter made of a compliant material having a very small, micro or nano outside diameter is provided. Then, the slots are formed in the catheter and the electrode segments are positioned within the slots.

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

Abstract: A catheter priming apparatus may include a barrier forming a reservoir. Fluid may be disposed within the reservoir. A support structure may be disposed within the barrier. The support structure may include an opening extending through the support structure and a connector configured to couple the catheter priming apparatus to a catheter system. A one-way valve may be coupled to the support structure and configured to allow the fluid to flow out of the reservoir through the connector in response to compression of a portion of the barrier aligned with the opening.

Abstract: An intelligent bioelectric module for use with a drug delivery system has a case and a set of at least two electrodes in electrical communication with a detection surface of the case. The case is configured so that, in use, the detection surface comes into electrical communication with (i) a second surface of the delivery system when a first surface of the delivery system has been put into contact with a tissue surface of a human or animal subject or (ii) the tissue surface that is adjacent to a portion contacted by the first surface of the delivery system or (iii) both the second surface and the tissue surface.

Abstract: According to some embodiments, a syringe may include a barrel; a delivery conduit; a plunger seal disposed within the barrel; and a plunger rod assembly affixed to an end of the barrel, the plunger rod assembly including a first plunger rod component comprising a first linear gear, a second plunger rod component disposed at least partially in the barrel and engaged with the plunger seal, wherein the second plunger rod component comprises a second linear gear, a first rotational gear having a plurality of gear teeth for engaging the first linear gear, and a second rotational gear having a second plurality of gear teeth for engaging the second linear gear, wherein the first rotational gear is coupled to the second rotational gear such that translation of the first plunger rod component causes translation of the second plunger rod component.