Abstract: Disclosed herein is a machine learning platform and system for data analysis including for purposes of providing digital evaluations and therapeutics.

Abstract: Elderly people suffer from health issues, and timely detection can save lives. State of the art techniques either make certain assumptions or require clinical data in order to perform the frailty detection, which affects the quality as well as cause inconvenience to the users. The disclosure herein generally relates to patient monitoring and, more particularly, to frailty detection using pedometer sensor data, PIR sensor data, and door sensor data. The system determines activity levels of the user being monitored, based on data from the pedometer sensors, PIR sensors, and door sensors, and based on the determined activity levels, further determines whether the user has frailty or not.

Abstract: A core collector is shaped as a crescent in cross-section and has lateral sides formed into axially extending rows of axially spaced teeth. The arc angle of the crescent shape is sufficient to keep the core collector radially centered in a cannula by having the crescent's lateral sides bear against the inside of the cannula. The set of a core collector and cannula can be used in a known biopsy system to replace the known cannula and core collector of can be used in a new core biopsy instrument.

Abstract: A temperature probe for monitoring temperatures of a surface of a tissue or organ within the body of a subject includes a section with a substantially two-dimensional arrangement and a plurality of temperature sensors positioned across an area defined by the substantially two-dimensional arrangement. Such an apparatus may be used in conjunction with procedures in which thermal techniques are used to diagnose a disease state or treat diseased tissue. Specifically, a temperature probe may be used to monitor temperatures across an area of a surface of a tissue or organ located close to the treated tissue to prevent subjection of the monitored tissue or organ to potentially damaging temperatures.

Abstract: Catheters for ablation and removal of occlusions from blood vessels are provided. Laser cutting systems and mechanical cutting systems are provided in catheter devices, the cutting systems operable to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation. Catheters include expandable distal ends to facilitate, in some cases, relatively high bodily material removal rates compared to other devices.

Abstract: A biopsy needle has a cylindrical shell outer cannula and a stylet consisting of an inner stylet and outer stylet, both of which are inserted into the cylindrical cannula. The outer stylet has a series of strain relieved slits which provide bending over a deflection region in one direction, and the outer stylet is formed from a material such as a shape memory alloy (SMA) having a superelastic phase. The deflection is generated by an SMA wire spanning a deflection extent and attached to the outer stylet on either side of the deflection extent. The inner stylet, when positioned inside the outer stylet, has one or more actuation fibers which couple optical energy into the SMA wire, causing a deflection of the outer stylet over the deflection extent, with the optical energy provided to the actuation fibers for control of the deflection. Additional fibers may be placed in the inner stylet to measure temperature and to measure deflection.

Abstract: A biopsy device includes a first jaw and a second jaw pivotally connected to the first jaw through a pivot. The second jaw has a lever arm extending rearward from the pivot when the second jaw is closed. A wire having an end is connected to the lever arm of the second jaw. A suction tube is disposed between the first and second jaw.

Abstract: A tissue biopsy device includes an input configured to receive a rotational input and to rotate in a first direction in response thereto, an outer tube, and an inner cutting member extending through the outer tube. A mechanism couples the input with at least one of the inner tube or the outer tube and/or one of the inner tube or the outer tube is coupled to the input such that rotation of the input in the first direction drives rotation of the one of the outer tube or the inner cutting member in the first direction and drives rotation of the other of the outer tube or the inner cutting member in a second, opposite direction.

Abstract: Devices and methods for performing a skin biopsy are discussed herein. The skin biopsy device provides for consistent depth and shape, such as by reducing or eliminating operator error or inter-operator variability by generating the same forces across multiple uses. The skin biopsy device can also eliminate puckering of wound closures by incorporating a fusiform blade (e.g., elliptical blade or a diamond-shaped blade). The skin biopsy device includes a casing, a firing pin, a retaining rod, and a blade. The retaining rod holds the blade or can attach to a punch biopsy. The firing pin generates and impacts the retaining rod with a force necessary to drive the blade a given depth into a target tissue to obtain a biological sample.

Abstract: A calibration fixture provides a repeatably accurate tool for measuring offset angles between measurement axes for inertial measurement units (IMUs) used in motion capture. The measured offset angles may be used to correct angles measured by the IMUs to create a biomechanical skeleton that accurately represents movements of a motion capture subject. The disclosed embodiments are applied segments of a biomechanical skeleton providing a mathematical model of a human arm and hand.

Abstract: A biopsy device includes a cutting cannula and an inner member. The inner member has a rotatable toothed rack, a sharpened distal tip, and a sample notch. The inner member is configured to be received in the cutting cannula. The rotatable toothed rack has a proximal portion and a rotation zone in the proximal portion. The rotation zone of the rotatable toothed rack has circumferential toothing configured as a series of longitudinally spaced cut-outs that run around an entire circumference of the rotatable toothed rack to facilitate both a longitudinal movement and a rotational movement of the rotatable toothed rack and inner member. A drive is configured to engage the circumferential toothing to move the rotatable toothed rack within the cutting cannula in at least one of the longitudinal movement and the rotational movement.

Abstract: Embodiments of devices and methods for collecting gastrointestinal samples using a capsule-shaped device that is swallowed are provided.

Abstract: A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A function mapping is executed from said neurophysiological and neurovascular data to a target that is one of a glymphatic flow marker, a molecular analysis marker of neurodegeneration, or a neuroimaging marker of neurodegeneration. A target prediction model is output based on the function mapping. The target prediction model can receive new neurophysiological and neurovascular data and output a predicted marker of neurodegeneration.

Abstract: The present invention relates to a medical device. In particular, the present invention concerns a medical device which can be detected by means of magnetic resonance imaging (MRI).

Abstract: There is a skin analysis device for attachment to an electronic device of a human user, the electronic device having at least one skin characteristic measurement device, the skin analysis device comprising an enclosure comprising an enclosure body, configured to be removably connected to the electronic device and one or more skin characteristic measurement assisters, connected to the enclosure and configured to assist one or more skin characteristic measurement devices take a skin characteristic sample of a skin characteristic of the human user.

Abstract: A system is suggested comprising an optical sensing means and a processing unit. The optical sensing means may include an optical guide with a distal end, wherein the optical guide may be configured to be arranged in a device to be inserted into tissue in a region of interest. The processing unit may be configured to receive information of a region of interest including different tissue types as well as of a path through the tissues, to determine a sequence of tissue types along the path, to determine a tissue type at the distal end of the optical guide based on information received from the optical sensing means, to compare the determined tissue type with the tissue types on the path, to determine possible positions of the distal end of the optical guide on the path based on the comparison of tissue types, and to generate a signal indicative for the possible positions.

Abstract: An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.

Abstract: Some embodiments of the invention relate to an applicator for applying ultrasound energy to a tissue volume, comprising: an array comprising a plurality of ultrasound transducers, the transducers arranged side by side, the transducers configured to emit unfocused ultrasound energy suitable to thermally damage at least a portion of the tissue volume, each of the transducers comprising a coating thin enough so as not to substantially affect heat transfer via the coating to the tissue; and a cooling module configured to apply cooling via the transducers to prevent overheating of a surface of the tissue volume being contacted by the transducers.

Abstract: A system comprising a biopsy needle device comprising a cannula comprising a distal end configured to sever a tissue sample, and a trocar disposed within the cannula comprising a notch configured to retain a tissue sample, wherein at least one of the cannula and the trocar is divided into at least two segments including different echogenic coatings, an ultrasound probe, and a processor configured and arranged to collect images from the ultrasound probe and color code the at least two segments based on at least one characteristic relating to different echogenic coatings, surface textures, surface contours and dimensions of the biopsy device.

Abstract: The present disclosure provides methods for evaluating tissue damage and the use of spatial variation in Sub-Epidermal Moisture (SEM) values to determine damaged tissue for clinical intervention. The present disclosure provides methods of identifying deep and early-stage pressure-induced injuries or ulcers (PI/PU). The present disclosure provides algorithm for computing SEM delta values which inform clinical decision-making for developing intact skin PI/PUs including suspected deep tissue injury (sDTI) and Stage I PI/PUs.