Abstract: Disclosed are methods to treat patients with AFib by monitoring their heart rhythm to determine the presence and/or the number of episodes of long duration AFib, and optionally the extent of AFib burden. Patients who meet threshold requirements are qualified for the treatment of AFib with a dosage of budiodarone. Patient monitoring is continued in order confirm that the patient is and remains responsive to budiodarone therapy including dose adjusting the patient to achieve such therapy. Subsequently, monitoring is continued to confirm that the patient remains responsive. These methods allow for treatment of the AFib and, correspondingly, reduce or delay the risk of stroke and/or congestive heart failure in the treated patient.

Abstract: The present disclosure includes an electromagnetic field detection and monitoring system. The system includes a single-ended amplifier and an impedance matching circuit which matches the impedance caused by an air gap between tissue and an electrode. The system includes passive detection, active detection, and signal processing capabilities. At least one embodiment includes a body worn system with sensing, processing, communications, and data storage capabilities. The system provides wearable antennas to transfer the EMF energy in its electrical or magnetic forms into the sensor efficiently. A specially designed processing algorithm can process the collected data and generated the results for medical professionals to read and make decisions. The processing can include machine learning technique which decompose an EMF signal into EEG bands to perform feature extraction. The features can then be used to train a machine learning model to classify other EMF signals.

Abstract: A model of flow through a left ventricular assist device (LVAD) can be used for preoperative planning of implantation of the LVAD into a patient and/or optimization of the LVAD after implantation into the patient are described. At least one imaging data set related to a patient and at least one physiological data set related to the patient can be received. An ideal parameter related to the LVAD can be determined based on the at least one imaging data set related to the patient, the at least one physiological data set related to the patient using a model of circulation in a large spatial region of the patient's body and a three-dimensional anatomical model of at least one component of the region of the patient's body and at least one component of the LVAD. Flow patterns within the three-dimensional anatomical model are calculated using computational fluid dynamics.

Abstract: A method includes: prompting a user to recite a story associated with a first target emotion; recording the user reciting the story and recording a first timeseries of biosignal data via a set of sensors integrated into a wearable device worn by the user; accessing a first timeseries of emotion markers extracted from the voice recording; labeling the first timeseries of biosignal data according to the first timeseries of emotion markers; generating an emotion model linking biosignals to emotion markers for the user based on the first emotion-labeled timeseries of biosignal data; detecting a second instance of the first target emotion exhibited by the user based on a second timeseries of biosignal data and the emotion model; and notifying the user of the second instance of the first target emotion.

Abstract: Non-invasive blood pressure (NIBP) systems and methods are disclosed that measure a blood pressure, and in some examples a beat-to-beat blood pressure, of a patient without restricting blood flow. The NIBP systems determine an efficacy of administered cardiopulmonary resuscitation (CPR) to the patient based on the measured blood pressure and are able to optionally output the CPR efficacy or generate user prompts based on the CPR efficacy. Further, the disclosed NIBP systems can generate user instructions to administer further treatment to the patient based on the CPR efficacy.

Abstract: The present invention concerns a device for the ventricular emergency support, comprising: a first flexible catheter (2), with a variable transversal section, provided with an extremal balloon (7) for the controlled occlusion of the ascending aorta (AA) of the treated patient; a first pump (12), associated to said first catheter (2) for the aspiration and contemporary input of equivalent blood quantifies into the blood circle of the treated patient; a second flexible catheter (32), with a fixed transversal section, provided with a couple of extremal balloons (34), spaced apart, for the controlled occlusion of the inferior vena cava (CA) and of the superior vena cava (CD) of the treated patient; a second pump (35), associated to said first and second catheter (2, 32) for inflating and deflating said extremal balloons (7, 34) of said first and second catheter (2, 32); an electronic control unit (36) for adjusting and controlling the operational parameters of said first and second pump (12, 35), and for the dete

Abstract: A medical electrical lead includes a lead body, a high voltage electrode positioned on the lead body, the high voltage electrode comprising a proximal coated portion, a distal coated portion, and an uncoated portion. Additionally, the medical electrical lead includes a first low voltage electrode and a second low voltage electrode distal to the first low voltage electrode, wherein a first line passes through the first low voltage electrode and the second low voltage electrode, wherein a second line passes through the first low voltage electrode and the uncoated portion, the second line forming a first angle with the first line, and wherein a third line passes through the second low voltage electrode and the uncoated portion, the third line forming a second angle with the first line.

Abstract: A system for processing a portion in a processing volume of a transparent material by application of focused radiation including a device for generating and an optical system for focusing radiation, with a device for changing the position of the focus of the radiation and a control device. The system includes a controller that controls the ophthalmologic therapy system. The controller is encoded with a scan pattern. The scan pattern includes adjacent strokes with each adjacent stroke having an angle of inclination (?) to the beam axis; and the angle of inclination (?) of the strokes to the beam axis is always larger than or equal to the focal angle (?) of the focused radiation.

Abstract: Systems, devices, and techniques are described for analyzing evoked compound action potentials (ECAP) signals to assess the effect of a delivered electrical stimulation signal. In one example, a system includes a stimulation generator configured to deliver a stimulation pulse to a patient, sensing circuitry configured to sense an evoked compound action potential (ECAP) signal evoked from the stimulation pulse, and processing circuitry. The processing circuitry may be configured to determine a maximum value of a derivative of the ECAP signal, determine a minimum value of the derivative of the ECAP signal, determine, based on the maximum value of the derivative and the minimum value of the derivative, a characteristic value of the ECAP signal, and determine, based on the characteristic value of the ECAP signal, at least one parameter value at least partially defining electrical stimulation therapy to be delivered to the patient.

Abstract: Systems, methods and devices for reducing noise in cardiac monitoring including wearable monitoring devices having at least one electrode for cardiac monitoring; in some implementations, the wearable device using a composite adhesive having at least one conductive portion applied adjacent the electrode; and, in some implementations, including circuitry adaptations for the at least one electrode to act as a proxy driven right leg electrode.

Abstract: The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining whether a patient is experiencing atrial fibrillation (AF). If the patient is experiencing AF, the efficacy of CRT is determined. A signal is sensed in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal and a determination is made as to whether the ventricular pacing stimulus evoked a response from the ventricle.

Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.

Abstract: The present invention is an oral heating element designed to apply heat and increase blood circulation along the gums to prevent and treat gum disease. The oral heating apparatus is designed to fit inside the mouth for extended periods of time. The heating element has a heating filament encased in a food safe plastic sheath capable of transmitting heat evenly along the surface of the sheath facing the gums.

Abstract: A catheter pump system is disclosed. The catheter pump system can include a shaft assembly and an impeller coupled with a distal portion of the shaft assembly. The catheter pump system can include a motor assembly, the motor assembly comprising a chamber and a shaft-driving portion disposed in the chamber. The shaft-driving portion can be configured to impart rotation to the impeller through the shaft assembly. The chamber can be filled with a gas that at least partially surrounds the shaft-driving portion. A fluid pathway can convey fluid proximally during operation of the catheter pump system. A bypass pathway can be in fluid communication with the fluid pathway, the bypass pathway configured to direct at least a portion of the fluid to bypass the chamber.

Abstract: Disclosed herein are systems and methods for aiding a surgeon to perform a surgical procedure on an eye. The surgical procedure includes inserting an elongate probe from an opening into the eye across an anterior chamber to a target tissue region comprising a trabecular meshwork and a Schlemm's canal. Exemplary systems include an optical microscope for the surgeon to view the eye with a microscope image during the procedure; an optical coherence tomography (OCT) apparatus configured to perform an OCT scan of a target location in the target tissue region during the procedure; and an image processing apparatus configured to generate an augmented image by overlaying an OCT image of target location and a graphical visual element identifying the locations, wherein the graphical visual element is registered with the microscope image to aid the surgeon in advancing a distal end of the elongate probe to the target location.

Abstract: Methods are provided for treating diseases by altering body mass composition in a human subject through application of galvanic vestibular stimulation (GVS) using electrodes placed in electrical contact with the subject's scalp at a location corresponding to each of the subject's left and right vestibular systems. The methods may be used to treat obesity-related diseases such as diabetes, hypertension, type 2 diabetes mellitus and osteoporosis. GVS may be applied for a predetermined period of time at regular intervals.

Abstract: An apparatus comprising: circuitry configured to classify a signal; and circuitry configured to control saving of the signal to a memory with a conditional resolution, wherein a signal that is classified as anomalous is saved at higher resolution as a higher resolution signal and a signal that is not classified as anomalous is saved at lower resolution as a lower resolution signal or is not saved.

Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.

Abstract: Systems, methods, and computer program product embodiments are disclosed for displaying cardiac signals based on a signal pattern. An embodiment operates by accessing an input cardiac signal. The embodiment matches a portion of the input cardiac signal to a known signal pattern. The embodiment then displays an indication of a degree of the match.

Abstract: An attachment device has a sewing ring frame and a locking mechanism movably mounted on the sewing ring frame. The locking mechanism includes a biasing element projecting from the outer surface of the sewing ring frame and a slide substantially co-planar to the sewing ring frame. The slide further includes a first mating member. Additionally, the locking mechanism includes at least one guide member overlapping the slide and a locking pin disposed between the slide and the sewing ring frame. The biasing element is movably coupled to the locking pin and the slide and is transitionable between a first configuration in which the first mating member is in a disengaged position to a second configuration in which the first mating member is in an engaged position.